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HSP40 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203039
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSP40, Recombinant Protein

 Also Known As   

HSP40 (DNAJ), 1-340 aa, Human, His tag, E Coli

 Product Synonym Names    Heat shock 40 kDa protein 1; DNAJB1; DNAJ1; HDJ1; HSPF1; HSP40 (DNAJ); Heat shock 40 kDa protein 1; Heat shock protein 40; HSP40; DnaJ protein homolog 1; HDJ-1; DnaJ homolog subfamily B member 1; Heat shock 40 kDa protein 1; radial spoke 16 homolog B (Chlamydomonas); Hsp40; Sis1; RSPH16B
 Product Gene Name   

HSP40 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGKDYYQTLG LARGASDEEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE AYDVLSDPRK REIFDRYGEE GLKGSGPSGG SGGGANGTSF SYTFHGDPHA MFAEFFGGRN PFDTFFGQRN GEEGMDIDDP FSGFPMGMGG FTNVNFGRSR SAQEPARKKQ DPPVTHDLRV SLEEIYSGCT KKMKISHKRL NPDGKSIRNE DKILTIEVKK GWKEGTKITF PKEGDQTSNN IPADIVFVLK DKPHNIFKRD GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE GLPLPKTPEK RGDLIIEFEV IFPERIPQTS RTVLEQVLPI
 OMIM    X62421 mRNA
 3D Structure    ModBase 3D Structure for P25685
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris (pH 8.0), 2mM DTT, 0.2mMPMSF, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of HSP40 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HSP40 recombinant protein

   Human HSP40 (heat shock protein with molecular size of 40kDa) is one of the mammalian homologues of bacterial DnaJ heat shock protein and regulates cellular processes by aiding in the folding, transport and assembly. HSP40 protein contains the J-domain which controls interaction with the ATPase domain of DnaK. Recombinant human HSP40, his-tagged, is overexpressed in E Coli and purified by using the conventional column chromatography techniques.
 Product Categories/Family for HSP40 recombinant protein    Heat Shock Proteins
 Applications Tested/Suitable for HSP40 recombinant protein   

SDS-PAGE

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 SDS-Page of HSP40 recombinant protein    HSP40 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for HSP40. It may not necessarily be applicable to this product.
 NCBI GI #    5453690
 NCBI GeneID    3337
 NCBI Accession #    NP_006136 [Other Products]
 NCBI GenBank Nucleotide #    NM_006145.2 [Other Products]
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 UniProt Primary Accession #    P25685 [Other Products]
 UniProt Secondary Accession #    B4DX52 [Other Products]
 UniProt Related Accession #    P25685 [Other Products]
 Molecular Weight    40.2kDa (360aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    dnaJ homolog subfamily B member 1 isoform 1
 NCBI Official Synonym Full Names    DnaJ heat shock protein family (Hsp40) member B1
 NCBI Official Symbol    DNAJB1 [Similar Products]
 NCBI Official Synonym Symbols   
Hdj1; Sis1; HSPF1; Hsp40; RSPH16B
[Similar Products]
 NCBI Protein Information    dnaJ homolog subfamily B member 1
 UniProt Protein Name    DnaJ homolog subfamily B member 1
 UniProt Synonym Protein Names   
DnaJ protein homolog 1; Heat shock 40 kDa protein 1; HSP40; Heat shock protein 40; Human DnaJ protein 1; hDj-1
 UniProt Gene Name    DNAJB1 [Similar Products]
 UniProt Synonym Gene Names    DNAJ1; HDJ1; HSPF1; HSP40; Heat shock protein 40; hDj-1 [Similar Products]
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 NCBI Summary for HSP40    This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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 UniProt Comments for HSP40    Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
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Product References and Citations for HSP40 recombinant protein

   Hata M, Okumura K, Seto M, Ohtsuka K. (1996). Genomics 38 (3): 446-9; Manishkumar and Debashis Mitra. (2005). Journal of Biological Chemistry 280 (48): 40041-40050.;
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 Research Articles on HSP40    1. These results indicate that Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC) is similar to pure FL-HCC at the genomic level and the DNAJB1:PRKACA fusion can be used as a diagnostic tool for both pure and mFL-HCC
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSP40 recombinant proteinPathways associated with HSP40 recombinant protein
 Reference Product  PubMed Publications
 HSPA1A recombinant protein  >28 publications with HSP40 and HSPA1A
 HSPA8 recombinant protein  >25 publications with HSP40 and HSPA8
 HSPA6 recombinant protein  >6 publications with HSP40 and HSPA6
 HSPA2 recombinant protein  >3 publications with HSP40 and HSPA2
 HSPA5 recombinant protein  >2 publications with HSP40 and HSPA5
 HSPA4L recombinant protein  >1 publications with HSP40 and HSPA4L
 HSPA4 recombinant protein  >1 publications with HSP40 and HSPA4
 Products by Pathway  Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 HSF1-dependent Transactivation Pathway antibodies  HSF1-dependent Transactivation Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 MAPK Family Signaling Cascades Pathway antibodies  MAPK Family Signaling Cascades Pathway Diagram
 MAPK6/MAPK4 Signaling Pathway antibodies  MAPK6/MAPK4 Signaling Pathway Diagram
 NRF2 Pathway antibodies  NRF2 Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with HSP40 recombinant proteinOrgans/Tissues associated with HSP40 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >24 publications with HSP40 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >19 publications with HSP40 and Liver Diseases
 Liver Neoplasms Antibodies  >17 publications with HSP40 and Liver Neoplasms
 Inflammation Antibodies  >13 publications with HSP40 and Inflammation
 Disease Models, Animal Antibodies  >10 publications with HSP40 and Disease Models, Animal
 Lung Diseases Antibodies  >7 publications with HSP40 and Lung Diseases
 Fibrosis Antibodies  >6 publications with HSP40 and Fibrosis
 Cardiovascular Diseases Antibodies  >5 publications with HSP40 and Cardiovascular Diseases
 Heart Diseases Antibodies  >4 publications with HSP40 and Heart Diseases
 Kidney Diseases Antibodies  >3 publications with HSP40 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >30 publications with HSP40 and Liver
 Brain Antibodies  >25 publications with HSP40 and Brain
 Blood Antibodies  >22 publications with HSP40 and Blood
 Nerve Antibodies  >17 publications with HSP40 and Nerve
 Lung Antibodies  >7 publications with HSP40 and Lung
 Heart Antibodies  >6 publications with HSP40 and Heart
 Eye Antibodies  >5 publications with HSP40 and Eye
 Testis Antibodies  >5 publications with HSP40 and Testis
 Kidney Antibodies  >4 publications with HSP40 and Kidney
 Muscle Antibodies  >4 publications with HSP40 and Muscle
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