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HSP47 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203189
SDS-Page
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSP47, Recombinant Protein

 Also Known As   

HSP47 (Colligin), 18-418aa, Human, His tag, E Coli

 Product Synonym Names    Collagen-binding protein; Serpin H1; SERPINH1; RA-A47; AsTP3; Heme oxygenase 1; HSP47; Collogin; 47 kDa heat shock protein; 47 kDa heat shock protein precursor; Arsenic transactivated protein 3; AsTP 3; CBP 1; CBP 2; CBP1; CBP2; Collagen binding protein; SERPINH2; Collagen binding protein 1; Collagen binding protein 2; Colligen; Colligin 1; Colligin 2; gp46; Heat shock protein 47; HGNC 1547; Hsp 47; J6; PIG 14; PIG14; PPROM; Proliferation inducing gene 14; Proliferation inducing gene 14 protein; RA A47; Rheumatoid arthritis antigen A 47; Rheumatoid arthritis related antigen RA A47; Serine or cysteine proteinase inhibitor clade H member 1; Serine or cysteine proteinase inhibitor clade H member 2; Serpin H1; Serpin peptidase inhibitor clade H member 1.
 Product Gene Name   

HSP47 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAA EVKKPAAAAA PGTAEKLSPK AATLAERSAG LAFSLYQAMA KDQAVENILV SPVVVASSLG LVSLGGKATT ASQAKAVLSA EQLRDEEVHA GLGELLRSLS NSTARNVTWK LGSRLYGPSS VSFADDFVRS SKQHYNCEHS KINFRDKRSA LQSINEWAAQ TTDGKLPEVT KDVERTDGAL LVNAMFFKPH WDEKFHHKMV DNRGFMVTRS YTVGVMMMHR TGLYNYYDDE KEKLQIVEMP LAHKLSSLII LMPHHVEPLE RLEKLLTKEQ LKIWMGKMQK KAVAISLPKG VVEVTHDLQK HLAGLGLTEA IDKNKADLSR MSGKKDLYLA SVFHATAFEL DTDGNPFDQD IYGREELRSP KLFYADHPFI FLVRDTQSGS LLFIGRLVRP KGDKMRDEL
 OMIM    X61598 mRNA
 3D Structure    ModBase 3D Structure for P50454
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of HSP47 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HSP47 recombinant protein

   Description: Heat shock protein 47 (HSP47), also known as Colligin or Serpin H1, is a serpin which serves as a human chaperone protein for collagen. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein acts as a molecular chaperone facilitating the folding and assembly of procollagen molecules, retaining unfolded molecules within the ER, and assisting the transport of correctly folded-molecules from the ER to Golgi apparatus. Recombinant human HSP47/Colligin protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for HSP47 recombinant protein    Heat Shock Proteins
 Applications Tested/Suitable for HSP47 recombinant protein   

SDS-PAGE

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 SDS-Page of HSP47 recombinant protein    HSP47 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for HSP47. It may not necessarily be applicable to this product.
 NCBI GI #    32454741
 NCBI GeneID    871
 NCBI Accession #    NP_001226 [Other Products]
 NCBI GenBank Nucleotide #    NM_001235.3 [Other Products]
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 UniProt Primary Accession #    P50454 [Other Products]
 UniProt Secondary Accession #    P29043; Q5XPB4; Q6NSJ6; Q8IY96; Q9NP88; B3KVJ3 [Other Products]
 UniProt Related Accession #    P50454 [Other Products]
 Molecular Weight    48.9 kDa (439aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    serpin H1
 NCBI Official Synonym Full Names    serpin family H member 1
 NCBI Official Symbol    SERPINH1 [Similar Products]
 NCBI Official Synonym Symbols   
CBP1; CBP2; OI10; gp46; AsTP3; HSP47; PIG14; PPROM; RA-A47; SERPINH2
[Similar Products]
 NCBI Protein Information    serpin H1
 UniProt Protein Name    Serpin H1
 UniProt Synonym Protein Names   
47 kDa heat shock protein; Arsenic-transactivated protein 3; AsTP3; Cell proliferation-inducing gene 14 protein; Collagen-binding protein; Colligin; Rheumatoid arthritis-related antigen RA-A47
 UniProt Gene Name    SERPINH1 [Similar Products]
 UniProt Synonym Gene Names    CBP1; CBP2; HSP47; SERPINH2; AsTP3; Colligin [Similar Products]
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 NCBI Summary for HSP47    This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
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 UniProt Comments for HSP47    Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
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Product References and Citations for HSP47 recombinant protein

   Mohammed Tasab., et al. (2000) The EMBO Journal. 19 (10): 2204-2211; Maloney A., et al. (2007) Cancer Res. 67 (7):3239-53;
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 Research Articles on HSP47    1. miR-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSP47 recombinant proteinPathways associated with HSP47 recombinant protein
 Reference Product  PubMed Publications
 COL1A1 recombinant protein  >18 publications with HSP47 and COL1A1
 CRTAP recombinant protein  >13 publications with HSP47 and CRTAP
 COL1A2 recombinant protein  >13 publications with HSP47 and COL1A2
 LEPRE1 recombinant protein  >12 publications with HSP47 and LEPRE1
 PPIB recombinant protein  >9 publications with HSP47 and PPIB
 COL3A1 recombinant protein  >4 publications with HSP47 and COL3A1
 COL4A1 recombinant protein  >3 publications with HSP47 and COL4A1
 COL5A1 recombinant protein  >1 publications with HSP47 and COL5A1
 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with HSP47 recombinant proteinOrgans/Tissues associated with HSP47 recombinant protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >88 publications with HSP47 and Fibrosis
 Disease Models, Animal Antibodies  >30 publications with HSP47 and Disease Models, Animal
 Kidney Diseases Antibodies  >30 publications with HSP47 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >20 publications with HSP47 and Cardiovascular Diseases
 Inflammation Antibodies  >18 publications with HSP47 and Inflammation
 Liver Diseases Antibodies  >15 publications with HSP47 and Liver Diseases
 Necrosis Antibodies  >12 publications with HSP47 and Necrosis
 Liver Cirrhosis Antibodies  >11 publications with HSP47 and Liver Cirrhosis
 Neoplasms, Experimental Antibodies  >7 publications with HSP47 and Neoplasms, Experimental
 Heart Diseases Antibodies  >7 publications with HSP47 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >57 publications with HSP47 and Muscle
 Kidney Antibodies  >41 publications with HSP47 and Kidney
 Bone Antibodies  >35 publications with HSP47 and Bone
 Connective Tissue Antibodies  >35 publications with HSP47 and Connective Tissue
 Blood Antibodies  >34 publications with HSP47 and Blood
 Vascular Antibodies  >28 publications with HSP47 and Vascular
 Skin Antibodies  >28 publications with HSP47 and Skin
 Liver Antibodies  >27 publications with HSP47 and Liver
 Lung Antibodies  >25 publications with HSP47 and Lung
 Embryonic Tissue Antibodies  >17 publications with HSP47 and Embryonic Tissue
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