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HSP90 alpha recombinant protein

Scan QR to view Datasheet Catalog #    MBS515368
SDS-PAGE
Unit / Price
0.02 mg  /  $260 +1 FREE 8GB USB
0.05 mg  /  $415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSP90 alpha, Recombinant Protein

★Popular Item★
 Also Known As   

HSP90 alpha recombinant protein

 Product Synonym Names    HSP90AA1; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; HSP90N; HSPCAL1; HSPCAL4; FLJ31884; HSP90alpha Protein; HSP90a Protein
 Product Gene Name   

HSP90 alpha recombinant protein

[Similar Products]
 Product Synonym Gene Name    HSP90AA1; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; HSP90N; HSPCAL1; HSPCAL4; FLJ31884 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (102547075..102606086, complement). Location: 14q32.33
 OMIM    140571
 3D Structure    ModBase 3D Structure for P07900
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 Host    Sf9 insect cells
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 Purity/Purification    >90%
 Form/Format    50mM MOPS, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
 Concentration    0.2ug/ul (lot specific)
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 Type    Recombinant Fusion Protein
 Species    Human
 Tag Information    His tag
 Expression System    Sf9 insect cells using baculovirus
 Source Note    Recombinant full length human HSP90alpha was expressed by baculovirus in Sf9 insect cells
 Accession Number    NM 005348
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 Preparation and Storage    Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Stability: 1yr at -70 degree C from date of shipment.
 Other Notes    Small volumes of HSP90 alpha recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HSP90 alpha recombinant protein

   Recombinant full-length human HSP90 alpha was expressed by baculovirus in Sf9 insect cells using a C-terminal His tag.

Scientific Background: HSP90α is a member of the HSP90 family of proteins which are important molecular chaperones involved in signal transduction, cell cycle control, stress management, folding, degradation, and transport of proteins (1). HSP90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, including HER2/ERBB2, AKT, RAF1, BCR-ABL and mutated p53. HSP90 inhibitors bind to HSP90, and induce the proteasomal degradation of HSP90 client proteins. HSP90α is an important mediator of cancer cell invasion and is expressed extracellularly on fibrosarcoma and breast cancer cells where it interacts with MMP2 (2).
 Product Categories/Family for HSP90 alpha recombinant protein    Cell Stress & Chaperone Proteins; Signaling Proteins - Cell Stress & Chaperone Proteins
 Applications Tested/Suitable for HSP90 alpha recombinant protein   

Western Blot (WB)

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 SDS-PAGE of HSP90 alpha recombinant protein    The purity was determined to be >90% by densitometry . Approx. MW 94 kDa
HSP90 alpha recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HSP90 alpha. It may not necessarily be applicable to this product.
 NCBI GI #    154146190
 NCBI GeneID    3320
 NCBI Accession #    NP_005339.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005348 [Other Products]
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 UniProt Primary Accession #    P07900 [Other Products]
 UniProt Secondary Accession #    Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5; A8K500; B3KPJ9 [Other Products]
 UniProt Related Accession #    P07900 [Other Products]
 Molecular Weight    ~94 kDa
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 NCBI Official Full Name    Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1), transcript variant 2, mRNA
 NCBI Official Synonym Full Names    heat shock protein 90kDa alpha (cytosolic), class A member 1
 NCBI Official Symbol    HSP90AA1 [Similar Products]
 NCBI Official Synonym Symbols   
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-alpha; HSP 86; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kDa protein 1, alpha; renal carcinoma antigen NY-REN-38; heat shock 90kD protein, alpha-like 4; epididymis luminal secretory protein 52; heat shock 90kD protein 1, alpha-like 4
 UniProt Protein Name    Heat shock protein HSP 90-alpha
 UniProt Synonym Protein Names   
Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38
 UniProt Gene Name    HSP90AA1 [Similar Products]
 UniProt Synonym Gene Names    HSP90A; HSPC1; HSPCA; HSP 86; HSP86 [Similar Products]
 UniProt Entry Name    HS90A_HUMAN
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 NCBI Summary for HSP90 alpha    The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for HSP90 alpha    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Ref.15 Ref.22 Ref.28

Subunit structure: Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity. Ref.17 Ref.18 Ref.19 Ref.20 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.31 Ref.40 Ref.43 Ref.50 Ref.51

Subcellular location: Cytoplasm. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.42

Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.

Post-translational modification: ISGylated. Ref.41S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.

Sequence similarities: Belongs to the heat shock protein 90 family.
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Product References and Citations for HSP90 alpha recombinant protein

   1. Csermely, P. et al: The 90-kDa molecular chaperone family: structure, function, and clinical applications. Pharmacol Ther. 1998 Aug;79(2):129-68.
2. Eustace, B. K. et al:Functional proteomic screens reveal an essential extracellular role for hsp90-alpha in cancer cell invasiveness. Nature Cell Biol. 6: 507-514, 2004.
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 Research Articles on HSP90 alpha    1. role of HSP70 and 90 in modulation of JNK, ERK expression in preeclamptic placental endothelial cell
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSP90 alpha recombinant proteinPathways associated with HSP90 alpha recombinant protein
 Reference Product  PubMed Publications
 HIF1A recombinant protein  >3 publications with HSP90 alpha and HIF1A
 AKT1 recombinant protein  >2 publications with HSP90 alpha and AKT1
 STIP1 recombinant protein  >2 publications with HSP90 alpha and STIP1
 PTGES3 recombinant protein  >2 publications with HSP90 alpha and PTGES3
 ERBB2 recombinant protein  >1 publications with HSP90 alpha and ERBB2
 NR3C1 recombinant protein  >1 publications with HSP90 alpha and NR3C1
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
Diseases associated with HSP90 alpha recombinant proteinOrgans/Tissues associated with HSP90 alpha recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with HSP90 alpha and Neoplasms
 Nervous System Diseases Antibodies  >5 publications with HSP90 alpha and Nervous System Diseases
 Breast Neoplasms Antibodies  >3 publications with HSP90 alpha and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSP90 alpha and Carcinoma, Hepatocellular
 Infertility, Male Antibodies  >2 publications with HSP90 alpha and Infertility, Male
 Brain Diseases Antibodies  >2 publications with HSP90 alpha and Brain Diseases
 Liver Neoplasms Antibodies  >1 publications with HSP90 alpha and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with HSP90 alpha and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with HSP90 alpha and Kidney Diseases
 Necrosis Antibodies  >1 publications with HSP90 alpha and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with HSP90 alpha and Blood
 Brain Antibodies  >5 publications with HSP90 alpha and Brain
 Liver Antibodies  >3 publications with HSP90 alpha and Liver
 Lung Antibodies  >3 publications with HSP90 alpha and Lung
 Muscle Antibodies  >3 publications with HSP90 alpha and Muscle
 Testis Antibodies  >3 publications with HSP90 alpha and Testis
 Embryonic Tissue Antibodies  >2 publications with HSP90 alpha and Embryonic Tissue
 Kidney Antibodies  >2 publications with HSP90 alpha and Kidney
 Nerve Antibodies  >2 publications with HSP90 alpha and Nerve
 Bone Antibodies  >2 publications with HSP90 alpha and Bone
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