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Hp recombinant protein :: Haptoglobin (Hp) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1141822
SDS-PAGE
Unit / Price
0.05 mg (E-Coli)  /  $735 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $860 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,085 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,155 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,240 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,260 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,305 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,540 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,815 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,880 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,985 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,415 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Haptoglobin (Hp), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat Haptoglobin (Hp)

 Product Synonym Names    Haptoglobin; Liver regeneration-related protein LRRG173Cleaved into the following 2 chains:; 1. Haptoglobin alpha chain; 2. Haptoglobin beta chain
 Product Gene Name   

Hp recombinant protein

[Similar Products]
 Product Synonym Gene Name    Hp; Ba1-647 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    19-347aa; full length protein
 Sequence    VE LGNDATDIED DSCPKPPEIA NGYVEHLVRY RCRQFYKLQT EGDGIYTLNS EKQWVNPAAG DKLPKCEAVC GKPKHPVDQV QRIIGGSMDA KGSFPWQAKM ISRHGLTTGA TLISDQWLLT TAQNLFLNHS ENATAKDIAP TLTLYVGKNQ LVEIEKVVLH PERSVVDIGL IKLKQKVLVT EKVMPICLPS KDYVAPGRMG YVSGWGRNVN FRFTERLKYV MLPVADQEKC ELHYEKSTVP EKKGAVSPVG VQPILNKHTF CAGLTKYEED TCYGDAGSAF AVHDTEEDTW YAAGILSFDK SCAVAEYGVY VRATDLKDWV QETMAKN
 3D Structure    ModBase 3D Structure for P06866
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Hp recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Hp recombinant protein

   As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway .
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 SDS-PAGE of Hp recombinant protein    Hp recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Hp. It may not necessarily be applicable to this product.
 NCBI GI #    60097941
 NCBI GeneID    24464
 NCBI Accession #    NP_036714.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012582.2 [Other Products]
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 UniProt Primary Accession #    P06866 [Other Products]
 UniProt Secondary Accession #    Q5EBB4; Q7TP23 [Other Products]
 UniProt Related Accession #    P06866 [Other Products]
 Molecular Weight    42,475 Da
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 NCBI Official Full Name    haptoglobin
 NCBI Official Synonym Full Names    haptoglobin
 NCBI Official Symbol    Hp [Similar Products]
 NCBI Official Synonym Symbols   
Ba1-647
[Similar Products]
 NCBI Protein Information    haptoglobin; zonulin; liver regeneration-related protein LRRG173
 UniProt Protein Name    Haptoglobin
 UniProt Synonym Protein Names   
Liver regeneration-related protein LRRG173; ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain
 UniProt Gene Name    Hp [Similar Products]
 UniProt Synonym Gene Names    Ba1-647 [Similar Products]
 UniProt Entry Name    HPT_RAT
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 NCBI Summary for Hp    may bind hemoglobin and mediate hemoglobin catabolism in lung cells; may play a role in inflammatory response [RGD, Feb 2006]
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 UniProt Comments for Hp    HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Endoplasmic reticulum; Protease; Enzyme, misc.; Secreted; Secreted, signal peptide

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum

Molecular Function: antioxidant activity; protein homodimerization activity; hemoglobin binding; catalytic activity

Biological Process: response to drug; organ regeneration; immune system process; metabolic process; response to glucocorticoid stimulus; response to lipopolysaccharide; liver development; response to organic cyclic substance; response to L-ascorbic acid; response to organic substance; response to magnesium ion; response to hydrogen peroxide; response to heat; defense response to bacterium; response to lead ion; negative regulation of oxidoreductase activity; response to hypoxia; acute-phase response; spermatogenesis; response to electrical stimulus; response to cobalamin; acute inflammatory response; response to X-ray
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 Research Articles on Hp    1. This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Hp recombinant proteinDiseases associated with Hp recombinant protein
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1542 publications with Hp and Cardiovascular Diseases
 Inflammation Antibodies  >1057 publications with Hp and Inflammation
 Hypersensitivity Antibodies  >629 publications with Hp and Hypersensitivity
 Liver Diseases Antibodies  >567 publications with Hp and Liver Diseases
 Disease Models, Animal Antibodies  >508 publications with Hp and Disease Models, Animal
 Kidney Diseases Antibodies  >452 publications with Hp and Kidney Diseases
 Hypertension Antibodies  >446 publications with Hp and Hypertension
 Autoimmune Diseases Antibodies  >440 publications with Hp and Autoimmune Diseases
 Necrosis Antibodies  >438 publications with Hp and Necrosis
 Fibrosis Antibodies  >417 publications with Hp and Fibrosis
Organs/Tissues associated with Hp recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1173 publications with Hp and Liver
 Lung Antibodies  >1073 publications with Hp and Lung
 Connective Tissue Antibodies  >307 publications with Hp and Connective Tissue
 Spleen Antibodies  >144 publications with Hp and Spleen
 Uncharacterized Tissue Antibodies  >1 publications with Hp and Uncharacterized Tissue
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