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HSPA8 recombinant protein :: Heat Shock 70kDa Protein 8 (HSPA8) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009256 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.05 mg  /  $200 +1 FREE 8GB USB
0.1 mg  /  $290 +1 FREE 8GB USB
0.2 mg  /  $360 +1 FREE 8GB USB
0.5 mg  /  $690 +1 FREE 8GB USB
1 mg  /  $1,015 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heat Shock 70kDa Protein 8 (HSPA8), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Heat Shock 70kDa Protein 8 (HSPA8)

 Product Gene Name   

HSPA8 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Heat Shock 70kDa Protein 8 (HSPA8) (MBS2002024)
Antigen: Heat Shock 70kDa Protein 8 (HSPA8) (MBS2009256)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG S-DKVSSKN SLESYAFNMK ATVEDEKLQG KINDEDKQKI LDKCNEIINW LDKNQTAEKE EFEHQQKELE KVCNPIITKL YQSAG
 Chromosome Location    Chromosome: 11; NC_000011.9 (122928200..122933074, complement). Location: 11q24.1
 OMIM    600816
 3D Structure    ModBase 3D Structure for P11142
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 Host    E Coli
 Species Reactivity    Homo sapiens (Human)
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.05% sarcosyl and preservative.
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 Expression System    Prokaryotic expression
 Residues    Asp534~Gly615 (Accession # P11142) with N-terminal His-Tag
 Predicted isoelectric point    5.9
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of HSPA8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HSPA8 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for HSPA8 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of HSPA8 recombinant protein    HSPA8 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HSPA8. It may not necessarily be applicable to this product.
 NCBI GI #    5729877
 NCBI GeneID    3312
 NCBI Accession #    NP_006588.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006597.5 [Other Products]
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 UniProt Primary Accession #    P11142 [Other Products]
 UniProt Secondary Accession #    Q9H3R6 [Other Products]
 UniProt Related Accession #    P11142 [Other Products]
 Molecular Weight    10.8kDa
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 NCBI Official Full Name    heat shock cognate 71 kDa protein isoform 1
 NCBI Official Synonym Full Names    heat shock 70kDa protein 8
 NCBI Official Symbol    HSPA8 [Similar Products]
 NCBI Official Synonym Symbols   
LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; NIP71; HEL-33; HSPA10; HEL-S-72p
[Similar Products]
 NCBI Protein Information    heat shock cognate 71 kDa protein; LPS-associated protein 1; heat shock 70kd protein 10; epididymis luminal protein 33; heat shock cognate protein 54; constitutive heat shock protein 70; lipopolysaccharide-associated protein 1; N-myristoyltransferase inhibitor protein 71; epididymis secretory sperm binding protein Li 72p
 UniProt Protein Name    Heat shock cognate 71 kDa protein
 UniProt Synonym Protein Names   
Heat shock 70 kDa protein 8
 UniProt Gene Name    HSPA8 [Similar Products]
 UniProt Synonym Gene Names    HSC70; HSP73; HSPA10 [Similar Products]
 UniProt Entry Name    HSP7C_HUMAN
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 NCBI Summary for HSPA8    This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for HSPA8    HSC70: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Heat shock protein; Chaperone; RNA-binding

Chromosomal Location of Human Ortholog: 11q24.1

Cellular Component: nucleoplasm; spliceosome; extracellular space; focal adhesion; membrane; nucleolus; melanosome; plasma membrane; intracellular; nucleus; cytosol; ribonucleoprotein complex; ubiquitin ligase complex

Molecular Function: protein binding; enzyme binding; G-protein-coupled receptor binding; ubiquitin protein ligase binding; heat shock protein binding; ATPase activity; unfolded protein binding; ATPase activity, coupled; ATP binding

Biological Process: axon guidance; viral reproduction; transcription, DNA-dependent; chaperone cofactor-dependent protein folding; protein folding; regulation of cell cycle; neurotransmitter secretion; RNA splicing; response to unfolded protein; positive regulation of nuclear mRNA splicing, via spliceosome; nuclear mRNA splicing, via spliceosome; synaptic transmission; gene expression; protein refolding; post-Golgi vesicle-mediated transport; negative regulation of transcription, DNA-dependent
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 Research Articles on HSPA8    1. Altered expression of Hsc70 and eIF5A-1 may cause defects in nucleocytoplasmic transport and play a role in esophageal carcinogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSPA8 recombinant proteinPathways associated with HSPA8 recombinant protein
 Reference Product  PubMed Publications
 DNAJB1 recombinant protein  >22 publications with HSPA8 and DNAJB1
 STUB1 recombinant protein  >19 publications with HSPA8 and STUB1
 CFTR recombinant protein  >15 publications with HSPA8 and CFTR
 HSP90AA1 recombinant protein  >5 publications with HSPA8 and HSP90AA1
 BAG1 recombinant protein  >4 publications with HSPA8 and BAG1
 BAG2 recombinant protein  >2 publications with HSPA8 and BAG2
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Destabilization Of MRNA By AUF1 (hnRNP D0) Pathway antibodies  Destabilization Of MRNA By AUF1 (hnRNP D0) Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with HSPA8 recombinant proteinOrgans/Tissues associated with HSPA8 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >74 publications with HSPA8 and Neoplasms
 Nervous System Diseases Antibodies  >51 publications with HSPA8 and Nervous System Diseases
 Brain Diseases Antibodies  >37 publications with HSPA8 and Brain Diseases
 Cardiovascular Diseases Antibodies  >25 publications with HSPA8 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >24 publications with HSPA8 and Disease Models, Animal
 Fibrosis Antibodies  >17 publications with HSPA8 and Fibrosis
 Heart Diseases Antibodies  >16 publications with HSPA8 and Heart Diseases
 Necrosis Antibodies  >14 publications with HSPA8 and Necrosis
 Inflammation Antibodies  >12 publications with HSPA8 and Inflammation
 Liver Diseases Antibodies  >10 publications with HSPA8 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >92 publications with HSPA8 and Brain
 Blood Antibodies  >91 publications with HSPA8 and Blood
 Muscle Antibodies  >48 publications with HSPA8 and Muscle
 Liver Antibodies  >44 publications with HSPA8 and Liver
 Nerve Antibodies  >42 publications with HSPA8 and Nerve
 Heart Antibodies  >35 publications with HSPA8 and Heart
 Kidney Antibodies  >28 publications with HSPA8 and Kidney
 Vascular Antibodies  >16 publications with HSPA8 and Vascular
 Lung Antibodies  >13 publications with HSPA8 and Lung
 Bone Antibodies  >11 publications with HSPA8 and Bone
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