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HSP90AA1 recombinant protein :: Heat shock protein HSP 90-alpha (HSP90AA1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1472904 HSP90AA1 recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heat shock protein HSP 90-alpha (HSP90AA1), Recombinant Protein

 Also Known As   

Recombinant Bovine Heat shock protein HSP 90-alpha (HSP90AA1) , partial

 Product Gene Name   

HSP90AA1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    HSP90AA1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q76LV2
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Bovine
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HSP90AA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HSP90AA1. It may not necessarily be applicable to this product.
 NCBI GI #    60592792
 NCBI GeneID    281832
 NCBI Accession #    NP_001012688.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001012670.2 [Other Products]
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 UniProt Primary Accession #    Q76LV2 [Other Products]
 UniProt Related Accession #    Q76LV2 [Other Products]
 Molecular Weight    84,731 Da
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 NCBI Official Full Name    heat shock protein HSP 90-alpha
 NCBI Official Symbol    HSP90AA1 [Similar Products]
 NCBI Official Synonym Symbols   
HSPCA
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-alpha
 UniProt Protein Name    Heat shock protein HSP 90-alpha
 Protein Family    Heat shock protein
 UniProt Gene Name    HSP90AA1 [Similar Products]
 UniProt Synonym Gene Names    HSP90A; HSPCA [Similar Products]
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 UniProt Comments for HSP90AA1    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from Hsp90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Interacts with HECTD1 (via N-terminus) ().
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 Research Articles on HSP90AA1    1. Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of HSP90AA1 and PGES (prostaglandin-E synthase).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSP90AA1 recombinant proteinPathways associated with HSP90AA1 recombinant protein
 Reference Product  PubMed Publications
 HSPA1A recombinant protein  >10 publications with HSP90AA1 and HSPA1A
 HSPA8 recombinant protein  >8 publications with HSP90AA1 and HSPA8
 PTGES3 recombinant protein  >3 publications with HSP90AA1 and PTGES3
 HSPA1L recombinant protein  >2 publications with HSP90AA1 and HSPA1L
 CDC37 recombinant protein  >2 publications with HSP90AA1 and CDC37
 STIP1 recombinant protein  >2 publications with HSP90AA1 and STIP1
 HSPH1 recombinant protein  >1 publications with HSP90AA1 and HSPH1
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Arylhydrocarbon Receptor (AhR) Signaling Pathway antibodies  Arylhydrocarbon Receptor (AhR) Signaling Pathway Diagram
 Constitutive Androstane Receptor Pathway antibodies  Constitutive Androstane Receptor Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 EBV LMP1 Signaling Pathway antibodies  EBV LMP1 Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
Diseases associated with HSP90AA1 recombinant proteinOrgans/Tissues associated with HSP90AA1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with HSP90AA1 and Nervous System Diseases
 Carcinoma Antibodies  >11 publications with HSP90AA1 and Carcinoma
 Inflammation Antibodies  >6 publications with HSP90AA1 and Inflammation
 Liver Diseases Antibodies  >5 publications with HSP90AA1 and Liver Diseases
 Necrosis Antibodies  >5 publications with HSP90AA1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >5 publications with HSP90AA1 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >4 publications with HSP90AA1 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >3 publications with HSP90AA1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >3 publications with HSP90AA1 and Lung Neoplasms
 Infertility, Male Antibodies  >3 publications with HSP90AA1 and Infertility, Male
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with HSP90AA1 and Brain
 Lung Antibodies  >9 publications with HSP90AA1 and Lung
 Liver Antibodies  >7 publications with HSP90AA1 and Liver
 Muscle Antibodies  >6 publications with HSP90AA1 and Muscle
 Embryonic Tissue Antibodies  >4 publications with HSP90AA1 and Embryonic Tissue
 Reticulum Antibodies  >4 publications with HSP90AA1 and Reticulum
 Kidney Antibodies  >3 publications with HSP90AA1 and Kidney
 Ovary Antibodies  >1 publications with HSP90AA1 and Ovary
 Skin Antibodies  >1 publications with HSP90AA1 and Skin
 Uterus Antibodies  >1 publications with HSP90AA1 and Uterus
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