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HA recombinant protein :: Hemagglutinin-Influenza A Virus H3N2 Perth 16/09 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144822 HA recombinant protein
Unit / Price
0.001 mg  /  $140 +1 FREE 8GB USB
0.005 mg  /  $205 +1 FREE 8GB USB
0.05 mg  /  $1,125 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hemagglutinin-Influenza A Virus H3N2 Perth 16/09 (HA), Recombinant Protein

 Also Known As   

Recombinant Hemagglutinin-Influenza A Virus H3N2 Perth 16/09

 Product Synonym Names    Perth 16/09; Hemagglutinin-Influenza A Virus H3N2 Perth 16/09 Recombinant; Perth 16/09
 Product Gene Name   

HA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for C6KNH7
 Host    Baculovirus
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    The H3N2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of HA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HA recombinant protein

   Description: H3N2 produced in Hi-5 cell of Baculovirus is a single polypeptide chain containing 339 amino acids (17-345) and having a molecular mass of 37.8kDa.H3N2 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

Introduction: H3N2 is a subtype of the influenza A virus. Its name derives from the forms of the two kinds of proteins on the surface of its coat, hemagglutinin (H) and neuraminidase (N). H3N2 exchanges genes for internal proteins with other influenza subtypes. H3N2 has tended to dominate in prevalence over H1N1, H1N2, and influenza B. H3N2 strain descended from H2N2 by antigenic shift, in which genes from multiple subtypes re-assorted to form a new virus. Both the H2N2 and H3N2 strains contained genes from avian influenza viruses.H3N2 viruses are able to infect mammals and birds. In pigs, humans, and birds, the virus has mutated into many strains. Hemagglutinin(HA) binds to sialic acid-containing receptors on the cell surface, generating the attachment of the virus particle to the cell. HA has a vital part in the determination of host range restriction and virulence and is in charge of the diffusion of the virus into the cell cytoplasm by facilitating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.
 Product Categories/Family for HA recombinant protein    VIRAL ANTIGENS- INFLUENZA VIRUS; Viral Antigens; Influenza
NCBI/Uniprot data below describe general gene information for HA. It may not necessarily be applicable to this product.
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 UniProt Primary Accession #    C6KNH7 [Other Products]
 Molecular Weight    63,641 Da [Similar Products]
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 UniProt Protein Name    Hemagglutinin
 Protein Family    Hemagglutinin
 UniProt Gene Name    HA [Similar Products]
 UniProt Entry Name    C6KNH7_9INFA
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 UniProt Comments for HA    Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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