P04853.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
NCBI Official Full Name
Hemagglutinin-neuraminidase
UniProt Protein Name
Hemagglutinin-neuraminidase
UniProt Synonym Gene Names
UniProt Entry Name
HN_SENDZ
UniProt Comments for HN
Function: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
Catalytic activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Subunit structure: Homotetramer; composed of disulfide-linked homodimers
Probable. Interacts with F protein trimer. Ref.8 Ref.11
Subcellular location: Virion membrane; Single-pass type II membrane protein
Potential. Host cell membrane; Single-pass type II membrane protein
Potential. Note: Folded in the endoplasmic reticulum
By similarity.
Post-translational modification: N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides. Ref.6 Ref.10
Sequence similarities: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
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Products associated with HN recombinant protein
Pathways associated with HN recombinant protein
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