Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow HMOX1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Fas apoptotic inhibitory molecule 3 (Faim3) Recombinant Protein
 • PRPF18 Antibody
 • SCHISTOSOMA MANSONI Antibody
 • HMGA2 Antibody
 • Smad1-5-9 Antibody
 • RUNX3 Antibody
 • lymphoid-restricted membrane protein (LRMP) ELISA Kit
 • Neurofilament protein L (NF-L) ELISA Kit
 • LRPAP1 Recombinant Protein
 • Vasopressin-neurophysin 2-copeptin (AVP) ELISA Kit
 • A Disintegrin and Metalloprotease 12 (ADAM12) ELISA Kit
 • Serum amyloid (SAA) ELISA Kit
 • Clostridium difficile Toxin B Antibody
 • Sex Hormone Binding Globulin (SHBG) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

HMOX1 recombinant protein :: Heme Oxygenase 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143909 HMOX1 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heme Oxygenase 1 (HMOX1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Heme Oxygenase 1 HMOX1 Human

 Product Synonym Names    HO-1, HSP32, bK286B10, HMOX-1, Heme oxygenase 1, HMOX1, HO, HO1.
 Product Gene Name   

HMOX1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MERPQPHSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA SNKVQDSAPV ETPRGKPPLN TRSQAPL EHHHHHH
 OMIM    141250
 3D Structure    ModBase 3D Structure for P09601
Section Bar
Section Bar
 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    1 mg/ml solution containing 20mM Tris-HCl pH-8, 50mM NaCl, 0.1mM PMSF and 10% glycerol.
Section Bar
 Source    Escherichia Coli.
 Physical Appearance    Sterile filtered colorless solution.
Section Bar
 Preparation and Storage    Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
 Other Notes    Small volumes of HMOX1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for HMOX1 recombinant protein

   Description: HO-1 Human Recombinant protein produced in E Coli is a single, non-glycosylated, polypeptide chain containing 274 amino acids (1-266) and having a molecular mass of 31.4 kDa. HO-1 is fused to 8 amino acid His Tag at C-Terminus and purified by proprietary chromatographic techniques.

Introduction: HMOX1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is then converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HMOX1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme Oxygenase-1 is involved in the regulation of cardiovascular function and its adaptive response to a variety of stressors. HMOX1 is induced in the colon of ulcerative colitis. HMOX1 is found to overexpress with a higher extent of intraplaque angiogenesis implies a multi-faceted role for HMOX1 in modulating the progression of atherosclerosis. HMOX1 expression reduced LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha in murine and human macrophages.
 Product Categories/Family for HMOX1 recombinant protein    ENZYMES; Enzymes; Oxygenase
NCBI/Uniprot data below describe general gene information for HMOX1. It may not necessarily be applicable to this product.
 NCBI GI #    4504437
 NCBI GeneID    3162
 NCBI Accession #    NP_002124.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002133.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P09601 [Other Products]
 UniProt Related Accession #    P09601 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    heme oxygenase 1
 NCBI Official Synonym Full Names    heme oxygenase (decycling) 1
 NCBI Official Symbol    HMOX1 [Similar Products]
 NCBI Official Synonym Symbols   
HO-1; HSP32; HMOX1D; bK286B10
[Similar Products]
 NCBI Protein Information    heme oxygenase 1; heat shock protein, 32-kD
 UniProt Protein Name    Heme oxygenase 1
 Protein Family    Heme oxygenase
 UniProt Gene Name    HMOX1 [Similar Products]
 UniProt Synonym Gene Names    HO; HO1; HO-1 [Similar Products]
 UniProt Entry Name    HMOX1_HUMAN
Section Bar
 NCBI Summary for HMOX1    Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for HMOX1    HMOX1: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. Expressed at higher levels in renal cancer tissue than in normal tissue. Belongs to the heme oxygenase family.

Protein type: EC 1.14.99.3; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular space; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; nucleolus; caveola; cytosol; nucleus

Molecular Function: protein binding; signal transducer activity; protein homodimerization activity; enzyme binding; metal ion binding; phospholipase D activity; heme binding; heme oxygenase (decyclizing) activity

Biological Process: response to nicotine; cell death; cellular iron ion homeostasis; negative regulation of smooth muscle cell proliferation; negative regulation of mast cell degranulation; positive regulation of smooth muscle cell proliferation; positive regulation of vasodilation; excretion; erythrocyte homeostasis; regulation of transcription factor activity; heme catabolic process; regulation of blood pressure; small GTPase mediated signal transduction; porphyrin metabolic process; negative regulation of mast cell cytokine production; negative regulation of neuron apoptosis; angiogenesis; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; healing during inflammatory response; transmembrane transport; protein homooligomerization; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription factor activity; heme oxidation; cellular response to nutrient; regulation of angiogenesis; negative regulation of leukocyte migration; negative regulation of DNA binding; positive regulation of angiogenesis; iron ion homeostasis; positive regulation of chemokine biosynthetic process; DNA damage response, signal transduction resulting in induction of apoptosis; response to hydrogen peroxide; response to estrogen stimulus; endothelial cell proliferation; response to oxidative stress; smooth muscle hyperplasia

Disease: Heme Oxygenase 1 Deficiency; Pulmonary Disease, Chronic Obstructive
Table BarTOPTable Bar
 Research Articles on HMOX1    1. The present current evidence indicates that HO-1 induction mediated by multiple pathways can drive the phenotypic shift to M2 macrophages
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with HMOX1 recombinant proteinPathways associated with HMOX1 recombinant protein
 Reference Product  PubMed Publications
 NFE2L2 recombinant protein  >1042 publications with HMOX1 and NFE2L2
 HIF1A recombinant protein  >158 publications with HMOX1 and HIF1A
 NOS3 recombinant protein  >69 publications with HMOX1 and NOS3
 VEGFA recombinant protein  >39 publications with HMOX1 and VEGFA
 AKT1 recombinant protein  >14 publications with HMOX1 and AKT1
 USF2 recombinant protein  >5 publications with HMOX1 and USF2
 BLVRA recombinant protein  >5 publications with HMOX1 and BLVRA
 FOSL1 recombinant protein  >4 publications with HMOX1 and FOSL1
 SLC46A1 recombinant protein  >2 publications with HMOX1 and SLC46A1
 Products by Pathway  Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Heme Degradation Pathway antibodies  Heme Degradation Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Keap1-Nrf2 Pathway antibodies  Keap1-Nrf2 Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Porphyrins Pathway antibodies  Metabolism Of Porphyrins Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
Diseases associated with HMOX1 recombinant proteinOrgans/Tissues associated with HMOX1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1505 publications with HMOX1 and Inflammation
 Ischemia Antibodies  >854 publications with HMOX1 and Ischemia
 Reperfusion Injury Antibodies  >651 publications with HMOX1 and Reperfusion Injury
 Liver Diseases Antibodies  >452 publications with HMOX1 and Liver Diseases
 Hypertension Antibodies  >357 publications with HMOX1 and Hypertension
 Lung Injury Antibodies  >335 publications with HMOX1 and Lung Injury
 Myocardial Ischemia Antibodies  >276 publications with HMOX1 and Myocardial Ischemia
 Neurodegenerative Diseases Antibodies  >266 publications with HMOX1 and Neurodegenerative Diseases
 Fibrosis Antibodies  >229 publications with HMOX1 and Fibrosis
 Drug-Induced Liver Injury Antibodies  >208 publications with HMOX1 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2002 publications with HMOX1 and Blood
 Vascular Antibodies  >1425 publications with HMOX1 and Vascular
 Liver Antibodies  >1175 publications with HMOX1 and Liver
 Brain Antibodies  >890 publications with HMOX1 and Brain
 Lung Antibodies  >788 publications with HMOX1 and Lung
 Kidney Antibodies  >772 publications with HMOX1 and Kidney
 Muscle Antibodies  >752 publications with HMOX1 and Muscle
 Heart Antibodies  >701 publications with HMOX1 and Heart
 Bone Antibodies  >226 publications with HMOX1 and Bone
 Skin Antibodies  >215 publications with HMOX1 and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions