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HBb recombinant protein :: Hemoglobin Beta Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2029839 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $150 +1 FREE 8GB USB
0.05 mg  /  $290 +1 FREE 8GB USB
0.1 mg  /  $455 +1 FREE 8GB USB
0.2 mg  /  $560 +1 FREE 8GB USB
0.5 mg  /  $1,080 +1 FREE 8GB USB
1 mg  /  $1,610 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hemoglobin Beta (HBb), Recombinant Protein

 Also Known As   

Recombinant Hemoglobin Beta (HBb)

 Product Gene Name   

HBb recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Hemoglobin Beta (MBS2026228)
Antigen: Hemoglobin Beta (MBS2029839)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHH H SSGLVPRGSH MASMTGGQQM GRGSEFELRR QAC- MLTAEEKAAV TAFWGKVKVD EVGGEALGRL LVVYPWTQRF FESFGDLSTA DAVMNNPKVK AHGKKVLDSF SNGMKHLDDL KGTFAALSEL HCDKLHVDPE NFKLLGNVLV VVLARNFGKE FTPVLQADFQ KVVAGVANAL AHRYH
 OMIM    140700
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 Host    Host: E Coli
Source: Prokaryotic expression
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 Purity/Purification    >95%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
 Concentration    8.6 (lot specific)
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 Predicted Molecular Mass    20.6kDa
 Accurate Molecular Mass (KD)    20kDa
 Endotoxin    <1.0EU per 1ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Tag    two N-terminal Tags, His-tag and T7-tag
 Organism Species    Bos taurus; Bovine (Cattle)
 Fragment    Arg26~Glu178
 Usage    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of HBb recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for HBb recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of HBb recombinant protein    HBb recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for HBb. It may not necessarily be applicable to this product.
 NCBI GI #    410178713
 NCBI GeneID    3043
 NCBI Accession #    AFV63187.1 [Other Products]
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 UniProt Secondary Accession #    P02023; Q13852; Q14481; Q14510; Q45KT0; Q549N7; Q6FI08; Q6R7N2; Q8IZI1; A4GX73; B2ZUE0 [Other Products]
 UniProt Related Accession #    P68871 [Other Products]
 Molecular Weight    15,998 Da
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 NCBI Official Full Name    hemoglobin beta, partial
 NCBI Official Synonym Full Names    hemoglobin, beta
 NCBI Official Symbol    HBB [Similar Products]
 NCBI Official Synonym Symbols   
CD113t-C; beta-globin
[Similar Products]
 NCBI Protein Information    hemoglobin subunit beta
 UniProt Protein Name    Hemoglobin subunit beta
 UniProt Synonym Protein Names   
Beta-globin; Hemoglobin beta chain
 Protein Family    Hemoglobin
 UniProt Gene Name    HBB [Similar Products]
 UniProt Entry Name    HBB_HUMAN
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 NCBI Summary for HBb    The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HBb    HBB: Involved in oxygen transport from the lung to the various peripheral tissues. Defects in HBB may be a cause of Heinz body anemias (HEIBAN). This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency. Defects in HBB are the cause of beta-thalassemia (B-THAL). A form of thalassemia. Thalassemias are common monogenic diseases occurring mostly in Mediterranean and Southeast Asian populations. The hallmark of beta-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. Absence of beta chain causes beta(0)-thalassemia, while reduced amounts of detectable beta globin causes beta(+)-thalassemia. In the severe forms of beta-thalassemia, the excess alpha globin chains accumulate in the developing erythroid precursors in the marrow. Their deposition leads to a vast increase in erythroid apoptosis that in turn causes ineffective erythropoiesis and severe microcytic hypochromic anemia. Clinically, beta-thalassemia is divided into thalassemia major which is transfusion dependent, thalassemia intermedia (of intermediate severity), and thalassemia minor that is asymptomatic. Defects in HBB are the cause of sickle cell anemia (SKCA); also known as sickle cell disease. Sickle cell anemia is characterized by abnormally shaped red cells resulting in chronic anemia and periodic episodes of pain, serious infections and damage to vital organs. Normal red blood cells are round and flexible and flow easily through blood vessels, but in sickle cell anemia, the abnormal hemoglobin (called Hb S) causes red blood cells to become stiff. They are C-shaped and resembles a sickle. These stiffer red blood cells can led to microvascular occlusion thus cutting off the blood supply to nearby tissues. Defects in HBB are the cause of beta-thalassemia dominant inclusion body type (B-THALIB). An autosomal dominant form of beta thalassemia characterized by moderate anemia, lifelong jaundice, cholelithiasis and splenomegaly, marked morphologic changes in the red cells, erythroid hyperplasia of the bone marrow with increased numbers of multinucleate red cell precursors, and the presence of large inclusion bodies in the normoblasts, both in the marrow and in the peripheral blood after splenectomy. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: hemoglobin complex; extracellular region; cytosol

Molecular Function: haptoglobin binding; protein binding; peroxidase activity; hemoglobin binding; iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: receptor-mediated endocytosis; positive regulation of nitric oxide biosynthetic process; response to hydrogen peroxide; nitric oxide transport; protein heterooligomerization; hydrogen peroxide catabolic process; bicarbonate transport; oxygen transport; regulation of blood pressure; blood coagulation; regulation of blood vessel size

Disease: Fetal Hemoglobin Quantitative Trait Locus 1; Beta-thalassemia; Sickle Cell Anemia; Heinz Body Anemias; Beta-thalassemia, Dominant Inclusion Body Type; Malaria, Susceptibility To; Alpha-thalassemia
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 Research Articles on HBb    1. XmnI polymorphism is an important genotypic factor in Pakistani population for making a prospective diagnosis of thalassemia intermedia and predicting the severity of the disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HBb recombinant proteinPathways associated with HBb recombinant protein
 Reference Product  PubMed Publications
 HBA2 recombinant protein  >31 publications with HBb and HBA2
 HBA1 recombinant protein  >21 publications with HBb and HBA1
 HBG2 recombinant protein  >16 publications with HBb and HBG2
 KLF1 recombinant protein  >9 publications with HBb and KLF1
 HPX recombinant protein  >4 publications with HBb and HPX
 HBZ recombinant protein  >3 publications with HBb and HBZ
 AQP1 recombinant protein  >1 publications with HBb and AQP1
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway antibodies  Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway Diagram
 Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway antibodies  Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
Diseases associated with HBb recombinant proteinOrgans/Tissues associated with HBb recombinant protein
 Disease Name  Pubmed Publications
 Anemia Antibodies  >228 publications with HBb and Anemia
 beta-Thalassemia Antibodies  >206 publications with HBb and beta-Thalassemia
 Hemoglobinopathies Antibodies  >204 publications with HBb and Hemoglobinopathies
 Anemia, Sickle Cell Antibodies  >67 publications with HBb and Anemia, Sickle Cell
 alpha-Thalassemia Antibodies  >65 publications with HBb and alpha-Thalassemia
 Disease Models, Animal Antibodies  >36 publications with HBb and Disease Models, Animal
 Chromosome Aberrations Antibodies  >18 publications with HBb and Chromosome Aberrations
 Liver Diseases Antibodies  >14 publications with HBb and Liver Diseases
 Liver Neoplasms Antibodies  >11 publications with HBb and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >10 publications with HBb and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >265 publications with HBb and Blood
 Liver Antibodies  >71 publications with HBb and Liver
 Brain Antibodies  >30 publications with HBb and Brain
 Bone Antibodies  >30 publications with HBb and Bone
 Kidney Antibodies  >23 publications with HBb and Kidney
 Bone Marrow Antibodies  >21 publications with HBb and Bone Marrow
 Muscle Antibodies  >20 publications with HBb and Muscle
 Eye Antibodies  >19 publications with HBb and Eye
 Heart Antibodies  >18 publications with HBb and Heart
 Lung Antibodies  >14 publications with HBb and Lung
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