NP_414993.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
8,628 Da
NCBI Official Full Name
modulator of gene expression, with H-NS
NCBI Protein Information
modulator of gene expression, with H-NS
UniProt Protein Name
Hemolysin expression-modulating protein Hha
NCBI Summary for hha
Hha and Cnu are paralogs. [More information is available at EcoGene: EG10439]. Hha affects production of multiple proteins, causing pleiotropic effects on catabolite repression and other systems, and these effects are increased under conditions of higher osmotic strength . [More information is available at EcoCyc: EG10439].
UniProt Comments for hha
Down-regulates hemolysin (hly) expression in complex with H-NS (PubMed:1956303, PubMed:10778755, PubMed:11790731, PubMed:21600204). Stimulates transposition events in vivo (PubMed:8145648). Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex (PubMed:23543115). Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS (PubMed:23543115). Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR (PubMed:19909729). Decreases biofilm formation by repressing the transcription of fimbrial genes fimA and ihfA, and by repressing the transcription of tRNAs corresponding to rare codons, which are abundant in type 1 fimbrial genes (PubMed:18545668).
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