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HSPG2 recombinant protein :: Heparan Sulfate Proteoglycan 2 (HSPG2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011529
Unit / Price
0.01 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $230 +1 FREE 8GB USB
0.1 mg  /  $345 +1 FREE 8GB USB
0.2 mg  /  $430 +1 FREE 8GB USB
0.5 mg  /  $825 +1 FREE 8GB USB
1 mg  /  $1,215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heparan Sulfate Proteoglycan 2 (HSPG2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Heparan Sulfate Proteoglycan 2 (HSPG2)

 Product Gene Name   

HSPG2 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Heparan Sulfate Proteoglycan 2 (HSPG2) (MBS2001431)
Antigen: Heparan Sulfate Proteoglycan 2 (HSPG2) (MBS2011529)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2011529 Technical Datasheet    Technical Datasheet PDF
 Chromosome Location    Chromosome: 1; NC_000001.10 (22148737..22263750, complement). Location: 1p36.1-p34
 OMIM    142461
 3D Structure    ModBase 3D Structure for P98160
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 Host    E. coli
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 Purity/Purification    > 97%
 Concentration    Original Concentration: 200 ug/mL (lot specific)
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 Organism Species    Homo sapiens (Human)
 Source    Prokaryotic expression
 Residues    Leu4149~Ser4391
 Tags    N-terminal His Tag
 Subcellular Location    Secreted, Extracellular matrix
 Traits    Freeze-dried powder
 Buffer    20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose
 Predicted isoelectric point    6.0
 Predicted Molecular Mass    27.0kDa
 Accurate Molecular Mass    28kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of HSPG2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for HSPG2 recombinant protein   

Positive Control; Immunogen; SDS-PAGE; WB.

(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of HSPG2 recombinant protein    HSPG2 recombinant protein Sequence image
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 SDS-PAGE of HSPG2 recombinant protein    HSPG2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HSPG2. It may not necessarily be applicable to this product.
 NCBI GI #    126012571
 NCBI GeneID    3339
 NCBI Accession #    NP_005520.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_005529.5 [Other Products]
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 UniProt Primary Accession #    P98160 [Other Products]
 UniProt Secondary Accession #    Q16287; Q5SZI3; Q9H3V5 [Other Products]
 UniProt Related Accession #    P98160 [Other Products]
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 NCBI Official Full Name    basement membrane-specific heparan sulfate proteoglycan core protein
 NCBI Official Synonym Full Names    heparan sulfate proteoglycan 2
 NCBI Official Symbol    HSPG2 [Similar Products]
 NCBI Official Synonym Symbols   
PLC; SJA; SJS; HSPG; SJS1; PRCAN
[Similar Products]
 NCBI Protein Information    basement membrane-specific heparan sulfate proteoglycan core protein; perlecan proteoglycan; endorepellin (domain V region)
 UniProt Protein Name    Basement membrane-specific heparan sulfate proteoglycan core protein
 UniProt Synonym Protein Names   
Perlecan
 Protein Family    Small heat shock protein
 UniProt Gene Name    HSPG2 [Similar Products]
 UniProt Synonym Gene Names    HSPG; PLC [Similar Products]
 UniProt Entry Name    PGBM_HUMAN
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 NCBI Summary for HSPG2    This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
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 UniProt Comments for HSPG2    HSPG2: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Defects in HSPG2 are the cause of Schwartz-Jampel syndrome (SJS1); a rare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses. Defects in HSPG2 are the cause of dyssegmental dysplasia Silverman-Handmaker type (DDSH). The dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage.

Protein type: Secreted; Cell adhesion; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p36.1-p34

Cellular Component: extracellular matrix; lysosomal lumen; extracellular space; focal adhesion; Golgi lumen; plasma membrane; extracellular region; basal lamina

Molecular Function: protein C-terminus binding; protein binding; metal ion binding

Biological Process: cardiac muscle development; phototransduction, visible light; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; lipoprotein metabolic process; pathogenesis; embryonic skeletal morphogenesis; chondroitin sulfate metabolic process; extracellular matrix disassembly; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; protein localization; carbohydrate metabolic process; chondrocyte differentiation; angiogenesis; brain development; retinoid metabolic process; endochondral ossification

Disease: Schwartz-jampel Syndrome, Type 1; Dyssegmental Dysplasia, Silverman-handmaker Type
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 Research Articles on HSPG2    1. Data suggest that cancer cell-derived exosomes use heparan sulfate proteoglycans (HSPGs) for their internalization and functional activity, which significantly extends the emerging role of HSPGs as key receptors of macromolecular cargo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSPG2 recombinant proteinPathways associated with HSPG2 recombinant protein
 Reference Product  PubMed Publications
 SDC2 recombinant protein  >2 publications with HSPG2 and SDC2
 HPSE recombinant protein  >1 publications with HSPG2 and HPSE
 BGN recombinant protein  >1 publications with HSPG2 and BGN
 APP recombinant protein  >1 publications with HSPG2 and APP
 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with HSPG2 recombinant proteinOrgans/Tissues associated with HSPG2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >17 publications with HSPG2 and Nervous System Diseases
 Neoplasms Antibodies  >9 publications with HSPG2 and Neoplasms
 Mental Disorders Antibodies  >9 publications with HSPG2 and Mental Disorders
 Osteochondrodysplasias Antibodies  >9 publications with HSPG2 and Osteochondrodysplasias
 Disease Models, Animal Antibodies  >7 publications with HSPG2 and Disease Models, Animal
 Movement Disorders Antibodies  >5 publications with HSPG2 and Movement Disorders
 Kidney Diseases Antibodies  >5 publications with HSPG2 and Kidney Diseases
 Dementia Antibodies  >5 publications with HSPG2 and Dementia
 Alzheimer Disease Antibodies  >5 publications with HSPG2 and Alzheimer Disease
 Dyssegmental dysplasia Antibodies  >5 publications with HSPG2 and Dyssegmental dysplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with HSPG2 and Blood
 Bone Antibodies  >11 publications with HSPG2 and Bone
 Muscle Antibodies  >9 publications with HSPG2 and Muscle
 Vascular Antibodies  >8 publications with HSPG2 and Vascular
 Connective Tissue Antibodies  >7 publications with HSPG2 and Connective Tissue
 Embryonic Tissue Antibodies  >6 publications with HSPG2 and Embryonic Tissue
 Brain Antibodies  >5 publications with HSPG2 and Brain
 Eye Antibodies  >4 publications with HSPG2 and Eye
 Ovary Antibodies  >4 publications with HSPG2 and Ovary
 Liver Antibodies  >4 publications with HSPG2 and Liver
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