NP_036874.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
48,775 Da
NCBI Official Full Name
hepatocyte nuclear factor 3-alpha
NCBI Official Synonym Full Names
forkhead box A1
NCBI Official Synonym Symbols
NCBI Protein Information
hepatocyte nuclear factor 3-alpha
UniProt Protein Name
Hepatocyte nuclear factor 3-alpha
UniProt Synonym Protein Names
Forkhead box protein A1
UniProt Synonym Gene Names
NCBI Summary for Foxa1
may act as a transcription factor for hepatocyte specific gene expression [RGD, Feb 2006]
UniProt Comments for Foxa1
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Involved in glucose homeostasis; activates the GCG promoter. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Modulates the transcriptional activity of nuclear hormone receptors. Is required for maximal gene activation mediated by AR in the prostate. Negatively regulates AR transactivation via competition with coactivators such as NCOA2. Is involved in ESR1-mediated transcription. Involved in regulation of apoptosis. Involved in cell cycle regulation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.
Research Articles on Foxa1
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Products associated with Foxa1 recombinant protein
Pathways associated with Foxa1 recombinant protein
Diseases associated with Foxa1 recombinant protein
Organs/Tissues associated with Foxa1 recombinant protein
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