NP_032286.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
37,601 Da
NCBI Official Full Name
hepatocyte nuclear factor 3-gamma
NCBI Official Synonym Full Names
forkhead box A3
NCBI Protein Information
hepatocyte nuclear factor 3-gamma
UniProt Protein Name
Hepatocyte nuclear factor 3-gamma
UniProt Synonym Protein Names
Forkhead box protein A3
UniProt Synonym Gene Names
UniProt Comments for Foxa3
Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility.
Research Articles on Foxa3
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Products associated with Foxa3 recombinant protein
Pathways associated with Foxa3 recombinant protein
Diseases associated with Foxa3 recombinant protein
Organs/Tissues associated with Foxa3 recombinant protein
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