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HSV-2 gD recombinant protein :: Herpes Simplex Virus-2 gD Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553145 HSV-2 gD recombinant protein
Unit / Price
0.5 mg  /  $775 +1 FREE 8GB USB
1 mg  /  $1,235 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Herpes Simplex Virus-2 gD (HSV-2 gD), Recombinant Protein

 Also Known As   

Recombinant Herpes Simplex Virus-2 gD

 Product Synonym Names    Herpes Simplex Virus-2 gD Recombinant ; hsv-2; hsv2; herpes simplex; hhv
 Product Gene Name   

HSV-2 gD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P03172
 Host    E Coli
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 Purity/Purification    >95%, as determined by SDS-PAGE.
 Form/Format    Lyophilized from 25mM Tris-Hcl pH 7.2, 1mM EDTA and 50% glycerol.
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 Host Note    DNA sequence encoding immunodominant fragment of human Herpesvirus-2 Glycoprotein D was expressed in Escherichia Coli.
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
 Molecular Weight Note    Recombinant HSV-2 gD encodes the immunodominant sequences of the human Herpesvirus Glycoprotein D. This molecule has a calculated mass of approximately 14 kDa.

Recombinant HSV2 gD contains an N terminal GST purification tag and migrates as an approximately 40 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this protein can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of HSV-2 gD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HSV-2 gD recombinant protein

   Herpes simplex virus (HSV) glycoprotein D (gD) is essential for virus entry into cells, as well as for cell fusion and cell-to-cell spread. The functions of gD are best understood for virus entry, a process in which gD binds to "gD receptors," cell surface molecules that are more restricted in number than the glycosaminoglycans to which the virus initially adsorbs.
 Product Categories/Family for HSV-2 gD recombinant protein    Viral Antigens
 Application Notes for HSV-2 gD recombinant protein    Recombinant human Herpesvirus-2 gD antigen is suitable for ELISA and Western blots, excellent antigen for detection of HSV with minimal specificity problems.
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NCBI/Uniprot data below describe general gene information for HSV-2 gD. It may not necessarily be applicable to this product.
 NCBI GI #    262527545
 NCBI Accession #    P03172.2 [Other Products]
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 UniProt Primary Accession #    P03172 [Other Products]
 UniProt Secondary Accession #    A7U8A6 [Other Products]
 Molecular Weight    43,220 Da
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 NCBI Official Full Name    Envelope glycoprotein D
 UniProt Protein Name    Envelope glycoprotein D
 UniProt Gene Name    gD [Similar Products]
 UniProt Synonym Gene Names    US6; gD [Similar Products]
 UniProt Entry Name    GD_HHV23
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 UniProt Comments for HSV-2 gD    Function: Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and PVRL1. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL

By similarity.

Subunit structure: Homodimer

By similarity. Interacts with host receptor TNFRSF14. Interacts with host receptor PVRL1. Interacts with host receptor PVRL2. Interacts (via profusion domain) with gB; this interaction occurs in the absence of gH/gL. Interacts (via profusion domain) with gH/gL heterodimer; this interaction occurs in the absence of gB. Associates with the gB-gH/gL-gD complex. Interacts (via C-terminus) with UL11 tegument protein

By similarity. Ref.6 Ref.7

Subcellular location: Virion membrane; Single-pass type I membrane protein

By similarity. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs

By similarity.

Sequence similarities: Belongs to the herpesviridae glycoprotein D family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSV-2 gD recombinant proteinPathways associated with HSV-2 gD recombinant protein
 Reference Product  PubMed Publications
 FLNA recombinant protein  >12 publications with HSV-2 gD and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
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