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HK1 recombinant protein :: Hexokinase-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265449 HK1 recombinant protein
Unit / Price
0.05 mg  /  $195 +1 FREE 8GB USB
0.2 mg  /  $465 +1 FREE 8GB USB
0.5 mg  /  $815 +1 FREE 8GB USB
1 mg  /  $1,290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hexokinase-1 (HK1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant E.coli Hexokinase-1

 Product Gene Name   

HK1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    VHLGPKKPQA RKGSMADVPK ELMDEIHQLE DMFTVDSETL RKVVKHFIDE LNKGLTKKGG NIPMIPGWVM EFPTGKESGN YLAIDLGGTN LRVVLVKLSG NHTFDTTQSK YKLPHDMRTT KHQEELWSFI ADSLKDFMVE QELLNTKDTL PLGFTFSYPA SQNKINEGIL QRWTKGFDIP NVEGHDVVPL LQNEISKREL PIEIVALIND TVGTLIASYY TDPETKMGVI FGTGVNGAFY DVVSDIEKLE GKLADDIPSN SPMAINCEYG SFDNEHLVLP RTKYDVAVDE QSPRPGQQAF EKMTSGYYLG ELLRLVLLEL NEKGLMLKDQ DLSKLKQPYI MDTSYPARIE DDPFENLEDT DDIFQKDFGV KTTLPERKLI RRLCELIGTR AARLAVCGIA AICQKRGYKT GHIAADGSVY NKYPGFKEAA AKGLRDIYGW TGDASKDPIT IVPAEDGSGA GAAVIAALSE KRIAEGKSLG IIGA
 Chromosome Location    Chromosome: 10; NC_000010.10 (71029756..71161638). Location: 10q22
 OMIM    142600
 3D Structure    ModBase 3D Structure for P19367
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 Host    E Coli
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 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HK1. It may not necessarily be applicable to this product.
 NCBI GI #    188497754
 NCBI GeneID    3098
 NCBI Accession #    NP_000179.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000188.2 [Other Products]
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 UniProt Primary Accession #    P19367 [Other Products]
 UniProt Secondary Accession #    O43443; O43444; O75574; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5; E9PCK0 [Other Products]
 UniProt Related Accession #    P19367 [Other Products]
 Molecular Weight    102,486 Da [Similar Products]
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 NCBI Official Full Name    hexokinase-1 isoform HKI
 NCBI Official Synonym Full Names    hexokinase 1
 NCBI Official Symbol    HK1 [Similar Products]
 NCBI Official Synonym Symbols   
HKD; HKI; HXK1; HMSNR; HK1-ta; HK1-tb; HK1-tc
[Similar Products]
 NCBI Protein Information    hexokinase-1; HK I; glycolytic enzyme; hexokinase type I; brain form hexokinase
 UniProt Protein Name    Hexokinase-1
 UniProt Synonym Protein Names   
Brain form hexokinase; Hexokinase type I
 Protein Family    Hexokinase
 UniProt Gene Name    HK1 [Similar Products]
 UniProt Synonym Gene Names    HK I [Similar Products]
 UniProt Entry Name    HXK1_HUMAN
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 NCBI Summary for HK1    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]
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 UniProt Comments for HK1    HK1: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). HK-2 and its mitochondrial receptor (VDAC) play the most pivotal and direct roles in the ""Warburg effect"". Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). Four human isoforms are produced by alternative splicing and alternative initiation. Isoform HK1 is markedly elevated in rapidly growing tumor cells exhibiting high glucose catabolic rates. HK1 is present in most tissues but is especially prominent in brain and kidney. Isoform HK1-SC is is an integral membrane protein detected in round spermatids, condensing spermatids and mature sperm where it is found in the head membranes, mitochondria of the midpiece and the fibrous sheath of the flagellum. Isoform HK1-SA is first expressed during meiosis and continues to be present in postmeiotic germ cells while isoform HK1-SB is present only in postmeiotic germ cells.

Protein type: Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.1; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Mitochondrial

Chromosomal Location of Human Ortholog: 10q22

Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol; lipid raft

Molecular Function: protein binding; hexokinase activity; mannokinase activity; fructokinase activity; glucokinase activity; ATP binding

Biological Process: hexose metabolic process; glycolysis; hexose transport; glucose 6-phosphate metabolic process; carbohydrate phosphorylation; carbohydrate metabolic process; cell glucose homeostasis; pathogenesis; glucose transport; transmembrane transport

Disease: Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency; Neuropathy, Hereditary Motor And Sensory, Russe Type
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 Research Articles on HK1    1. The screening for novel Parkin substrate(s) identified mitochondrial hexokinase I (HKI) as a candidate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HK1 recombinant proteinPathways associated with HK1 recombinant protein
 Reference Product  PubMed Publications
 VDAC1 recombinant protein  >5 publications with HK1 and VDAC1
 GPI recombinant protein  >3 publications with HK1 and GPI
 PKM2 recombinant protein  >2 publications with HK1 and PKM2
 PFKL recombinant protein  >1 publications with HK1 and PFKL
 MPI recombinant protein  >1 publications with HK1 and MPI
 PKLR recombinant protein  >1 publications with HK1 and PKLR
 PFKM recombinant protein  >1 publications with HK1 and PFKM
 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Conversion Of Glucose To Acetyl CoA And Entry Into The TCA Cycle Pathway antibodies  Conversion Of Glucose To Acetyl CoA And Entry Into The TCA Cycle Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
Diseases associated with HK1 recombinant proteinOrgans/Tissues associated with HK1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >93 publications with HK1 and Neoplasms
 Carcinoma Antibodies  >41 publications with HK1 and Carcinoma
 Disease Models, Animal Antibodies  >21 publications with HK1 and Disease Models, Animal
 Hyperplasia Antibodies  >16 publications with HK1 and Hyperplasia
 Nervous System Diseases Antibodies  >14 publications with HK1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >12 publications with HK1 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >11 publications with HK1 and Neoplasms, Experimental
 Congenital Abnormalities Antibodies  >10 publications with HK1 and Congenital Abnormalities
 Necrosis Antibodies  >9 publications with HK1 and Necrosis
 Drug Toxicity Antibodies  >9 publications with HK1 and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >45 publications with HK1 and Blood
 Brain Antibodies  >35 publications with HK1 and Brain
 Skin Antibodies  >29 publications with HK1 and Skin
 Liver Antibodies  >20 publications with HK1 and Liver
 Muscle Antibodies  >20 publications with HK1 and Muscle
 Heart Antibodies  >19 publications with HK1 and Heart
 Kidney Antibodies  >10 publications with HK1 and Kidney
 Prostate Antibodies  >9 publications with HK1 and Prostate
 Testis Antibodies  >8 publications with HK1 and Testis
 Pancreas Antibodies  >7 publications with HK1 and Pancreas
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