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HK1 recombinant protein :: Hexokinase 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203049
SDS-Page
Unit / Price
0.1 mg  /  $510 +1 FREE 8GB USB
0.5 mg  /  $1,335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hexokinase 1 (HK1), Recombinant Protein

 Also Known As   

Hexokinase 1, 1-917 aa, Human, His tag, E Coli (Bioactivity Validated)

 Product Synonym Names    HK1; Hexokinase 1; EC 2.7.1.1; Hexokinase type I; HK I; Brain form hexokinase; Hexokinase-1; BB404130; dea; Glycolytic enzyme; HEXOKIN; Hexokinase PI; Hexokinase type I; Hexokinase; tumor isozyme; Hexokinase-A; HK1 tb; Hk1-s; HK1-ta; HK1-tc; HKI; HXK1; mHk1-s.
 Product Gene Name   

HK1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDETLIDIM TRFRKEMKNG LSRDFNPTAT VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE KNQNVHMESE VYDTPENIVH GSGSQLFDHV AECLGDFMEK RKIKDKKLPV GFTFSFPCQQ SKIDEAILIT WTKRFKASGV EGADVVKLLN KAIKKRGDYD ANIVAVVNDT VGTMMTCGYD DQHCEVGLII GTGTNACYME ELRHIDLVEG DEGRMCINTE WGAFGDDGSL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM YLGELVRLIL VKMAKEGLLF EGRITPELLT RGKFNTSDVS AIEKNKEGLH NAKEILTRLG VEPSDDDCVS VQHVCTIVSF RSANLVAATL GAILNRLRDN KGTPRLRTTV GVDGSLYKTH PQYSRRFHKT LRRLVPDSDV RFLLSESGSG KGAAMVTAVA YRLAEQHRQI EETLAHFHLT KDMLLEVKKR MRAEMELGLR KQTHNNAVVK MLPSFVRRTP DGTENGDFLA LDLGGTNFRV LLVKIRSGKK RTVEMHNKIY AIPIEIMQGT GEELFDHIVS CISDFLDYMG IKGPRMPLGF TFSFPCQQTS LDAGILITWT KGFKATDCVG HDVVTLLRDA IKRREEFDLD VVAVVNDTVG TMMTCAYEEP TCEVGLIVGT GSNACYMEEM KNVEMVEGDQ GQMCINMEWG AFGDNGCLDD IRTHYDRLVD EYSLNAGKQR YEKMISGMYL GEIVRNILID FTKKGFLFRG QISETLKTRG IFETKFLSQI ESDRLALLQV RAILQQLGLN STCDDSILVK TVCGVVSRRA AQLCGAGMAA VVDKIRENRG LDRLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCNVSF LLSEDGSGKG AALITAVGVR LRTEASS
 OMIM    M75126 mRNA
 3D Structure    ModBase 3D Structure for P19367
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl pH8.0, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Biological Activity    Specific activity is > 3,000 pmol/min/ug. One unit will convert 1 pmoles of D-Glucose to D-Glucose-6-phosphate per minute at pH 7.5 at 37C.
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of HK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HK1 recombinant protein

   Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In mammals, four distinct enzymes-types 1 to 4 hexokinases-have been identified. The enzyme is found in most cells, but there is tissue specificity for the particular type of hexokinase. Hexokinase1 is found in the adipose tissue and liver and encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this hexokinase1 have been associated with hemolytic anemia due to hexokinase deficiency. Recombinant human Hexokinase1, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for HK1 recombinant protein    Signal Transduction
 Applications Tested/Suitable for HK1 recombinant protein   

SDS-PAGE

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 SDS-Page of HK1 recombinant protein    HK1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for HK1. It may not necessarily be applicable to this product.
 NCBI GI #    188497754
 NCBI GeneID    3098
 NCBI Accession #    NP_000179 [Other Products]
 NCBI GenBank Nucleotide #    NM_000188.2 [Other Products]
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 UniProt Primary Accession #    P19367 [Other Products]
 UniProt Secondary Accession #    O43443; O43444; O75574; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5; E9PCK0 [Other Products]
 UniProt Related Accession #    P19367 [Other Products]
 Molecular Weight    104.6kDa (937aa) [Similar Products]
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 NCBI Official Full Name    hexokinase-1 isoform HKI
 NCBI Official Synonym Full Names    hexokinase 1
 NCBI Official Symbol    HK1 [Similar Products]
 NCBI Official Synonym Symbols   
HK; HKD; HKI; HXK1; RP79; HMSNR; HK1-ta; HK1-tb; HK1-tc; hexokinase
[Similar Products]
 NCBI Protein Information    hexokinase-1
 UniProt Protein Name    Hexokinase-1
 UniProt Synonym Protein Names   
Brain form hexokinase; Hexokinase type I; HK I
 Protein Family    Probable histidine kinase
 UniProt Gene Name    HK1 [Similar Products]
 UniProt Synonym Gene Names    HK I [Similar Products]
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 NCBI Summary for HK1    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]
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 UniProt Comments for HK1    MiscellaneousIn vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).
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Product References and Citations for HK1 recombinant protein

   Jon E. et al., (2003) J.Exp Biology. 206 : 2049-2057.; Furuta H. et al., (1996) Genomics. 36 (1):206-9.;
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 Research Articles on HK1    1. HK1 protein levels was decreased after luteolin treatment and partly restored when co-treated with luteolin and miR-34a inhibitor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HK1 recombinant proteinPathways associated with HK1 recombinant protein
 Reference Product  PubMed Publications
 PGM1 recombinant protein  >5 publications with HK1 and PGM1
 GPI recombinant protein  >4 publications with HK1 and GPI
 PFKP recombinant protein  >4 publications with HK1 and PFKP
 PFKM recombinant protein  >3 publications with HK1 and PFKM
 PMM2 recombinant protein  >2 publications with HK1 and PMM2
 FBP1 recombinant protein  >1 publications with HK1 and FBP1
 PFKL recombinant protein  >1 publications with HK1 and PFKL
 Products by Pathway  Pathway Diagram
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 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
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 Cori Cycle Pathway antibodies  Cori Cycle Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
Diseases associated with HK1 recombinant proteinOrgans/Tissues associated with HK1 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >26 publications with HK1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >25 publications with HK1 and Nervous System Diseases
 Hyperplasia Antibodies  >18 publications with HK1 and Hyperplasia
 Cardiovascular Diseases Antibodies  >16 publications with HK1 and Cardiovascular Diseases
 Necrosis Antibodies  >13 publications with HK1 and Necrosis
 Lung Diseases Antibodies  >10 publications with HK1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >9 publications with HK1 and Neoplasms, Experimental
 Heart Diseases Antibodies  >9 publications with HK1 and Heart Diseases
 Inflammation Antibodies  >8 publications with HK1 and Inflammation
 Liver Diseases Antibodies  >8 publications with HK1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >67 publications with HK1 and Blood
 Brain Antibodies  >52 publications with HK1 and Brain
 Skin Antibodies  >32 publications with HK1 and Skin
 Muscle Antibodies  >28 publications with HK1 and Muscle
 Liver Antibodies  >27 publications with HK1 and Liver
 Heart Antibodies  >26 publications with HK1 and Heart
 Lung Antibodies  >20 publications with HK1 and Lung
 Testis Antibodies  >13 publications with HK1 and Testis
 Kidney Antibodies  >13 publications with HK1 and Kidney
 Vascular Antibodies  >10 publications with HK1 and Vascular
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