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PDE8B recombinant protein :: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1222884 PDE8B recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), partial, Recombinant Protein

 Also Known As   

Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), partial

 Product Synonym Names    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; HsPDE8B; EC=3.1.4.17; Cell proliferation-inducing gene 22 protein
 Product Gene Name   

PDE8B recombinant protein

[Similar Products]
 Product Synonym Gene Name    PDE8B; PIG22 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614190
 3D Structure    ModBase 3D Structure for O95263
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PDE8B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PDE8B. It may not necessarily be applicable to this product.
 NCBI GI #    71164867
 NCBI GeneID    8622
 NCBI Accession #    NP_001025022.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001029851.2 [Other Products]
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 UniProt Primary Accession #    O95263 [Other Products]
 UniProt Secondary Accession #    Q5J7V7; Q86XK8; Q8IUJ7; Q8IUJ8; Q8IUJ9; Q8IUK0; Q8N3T2 [Other Products]
 UniProt Related Accession #    O95263 [Other Products]
 Molecular Weight    93,674 Da
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 NCBI Official Full Name    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3
 NCBI Official Synonym Full Names    phosphodiesterase 8B
 NCBI Official Symbol    PDE8B [Similar Products]
 NCBI Official Synonym Symbols   
ADSD; PPNAD3
[Similar Products]
 NCBI Protein Information    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; hsPDE8B; cell proliferation-inducing gene 22 protein; 3',5' cyclic nucleotide phosphodiesterase 8B
 UniProt Protein Name    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
 UniProt Synonym Protein Names   
Cell proliferation-inducing gene 22 protein
 Protein Family    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase
 UniProt Gene Name    PDE8B [Similar Products]
 UniProt Synonym Gene Names    HsPDE8B [Similar Products]
 UniProt Entry Name    PDE8B_HUMAN
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 NCBI Summary for PDE8B    The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
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 UniProt Comments for PDE8B    PDE8B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. Defects in PDE8B are the cause of striatal degeneration autosomal dominant (ADSD). It is a movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present. Defects in PDE8B are the cause of primary pigmented nodular adrenocortical disease type 3 (PPNAD3). PPNAD3 is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; EC 3.1.4.53; Phosphodiesterase

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; signal transducer activity; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity

Biological Process: behavioral fear response; cyclic nucleotide metabolic process; cAMP catabolic process; operant conditioning; two-component signal transduction system (phosphorelay); visual learning; neuromuscular process controlling balance; negative regulation of insulin secretion

Disease: Striatal Degeneration, Autosomal Dominant; Pigmented Nodular Adrenocortical Disease, Primary, 3
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 Research Articles on PDE8B    1. rs4704397 in phosphodiesterase 8B is associated with thyrotropin and thyroid hormone concentrations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDE8B recombinant proteinPathways associated with PDE8B recombinant protein
 Reference Product  PubMed Publications
 GNAS recombinant protein  >3 publications with PDE8B and GNAS
 Products by Pathway  Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with PDE8B recombinant proteinOrgans/Tissues associated with PDE8B recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with PDE8B and Nervous System Diseases
 Adrenal Hyperplasia, Congenital Antibodies  >4 publications with PDE8B and Adrenal Hyperplasia, Congenital
 Striatal Degeneration, Autosomal Dominant Antibodies  >3 publications with PDE8B and Striatal Degeneration, Autosomal Dominant
 Neurodegenerative Diseases Antibodies  >3 publications with PDE8B and Neurodegenerative Diseases
 Depressive Disorder Antibodies  >2 publications with PDE8B and Depressive Disorder
 Tremor Antibodies  >1 publications with PDE8B and Tremor
 Heart Diseases Antibodies  >1 publications with PDE8B and Heart Diseases
 Erectile Dysfunction Antibodies  >1 publications with PDE8B and Erectile Dysfunction
 Hypertension Antibodies  >1 publications with PDE8B and Hypertension
 Dysarthria Antibodies  >1 publications with PDE8B and Dysarthria
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >17 publications with PDE8B and Thyroid
 Brain Antibodies  >13 publications with PDE8B and Brain
 Pancreas Antibodies  >5 publications with PDE8B and Pancreas
 Liver Antibodies  >4 publications with PDE8B and Liver
 Muscle Antibodies  >3 publications with PDE8B and Muscle
 Testis Antibodies  >3 publications with PDE8B and Testis
 Kidney Antibodies  >2 publications with PDE8B and Kidney
 Heart Antibodies  >1 publications with PDE8B and Heart
 Prostate Antibodies  >1 publications with PDE8B and Prostate
 Lung Antibodies  >1 publications with PDE8B and Lung
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