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HRG recombinant protein :: Histidine-rich glycoprotein (HRG) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967215 HRG recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $930 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,000 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,130 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,245 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,360 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,380 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,435 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,540 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,950 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,060 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,085 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,340 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,710 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Histidine-rich glycoprotein (HRG), Recombinant Protein

 Also Known As   

Recombinant Human Histidine-rich glycoprotein (HRG)

 Product Synonym Names    Histidine-rich glycoprotein; Histidine-proline-rich glycoprotein; HPRG
 Product Gene Name   

HRG recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    19-525aa; Full length protein
 Sequence    VS PTDCSAVEPE AEKALDLINK RRRDGYLFQL LRIADAHLDR VENTTVYYLV LDVQESDCSV LSRKYWNDCE PPDSRRPSEI VIGQCKVIAT RHSHESQDLR VIDFNCTTSS VSSALANTKD SPVLIDFFED TERYRKQANK ALEKYKEEND DFASFRVDRI ERVARVRGGE GTGYFVDFSV RNCPRHHFPR HPNVFGFCRA DLFYDVEALD LESPKNLVIN CEVFDPQEHE NINGVPPHLG HPFHWGGHER SSTTKPPFKP HGSRDHHHPH KPHEHGPPPP PDERDHSHGP PLPQGPPPLL PMSCSSCQHA TFGTNGAQRH SHNNNSSDLH PHKHHSHEQH PHGHHPHAHH PHEHDTHRQH PHGHHPHGHH PHGHHPHGHH PHGHHPHCHD FQDYGPCDPP PHNQGHCCHG HGPPPGHLRR RGPGKGPRPF HCRQIGSVYR LPPLRKGEVL PLPEANFPSF PLPHHKHPLK PDNQPFPQSV SESCPGKFKS GFPQVSMFFT HTFPK
 OMIM    gene 613116
 3D Structure    ModBase 3D Structure for P04196
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HRG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HRG recombinant protein

   This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein s effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
NCBI/Uniprot data below describe general gene information for HRG. It may not necessarily be applicable to this product.
 NCBI GI #    4504489
 NCBI GeneID    3273
 NCBI Accession #    NP_000403.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000412.3 [Other Products]
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 UniProt Primary Accession #    P04196 [Other Products]
 UniProt Secondary Accession #    B9EK35; D3DNU7 [Other Products]
 UniProt Related Accession #    P04196 [Other Products]
 Molecular Weight    59,578 Da
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 NCBI Official Full Name    histidine-rich glycoprotein
 NCBI Official Synonym Full Names    histidine-rich glycoprotein
 NCBI Official Symbol    HRG [Similar Products]
 NCBI Official Synonym Symbols   
HPRG; HRGP; THPH11
[Similar Products]
 NCBI Protein Information    histidine-rich glycoprotein; histidine-proline-rich glycoprotein
 UniProt Protein Name    Histidine-rich glycoprotein
 UniProt Synonym Protein Names   
Histidine-proline-rich glycoprotein; HPRG
 UniProt Gene Name    HRG [Similar Products]
 UniProt Synonym Gene Names    HPRG [Similar Products]
 UniProt Entry Name    HRG_HUMAN
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 NCBI Summary for HRG    This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HRG    HRG: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in an heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Defects in HRG are the cause of thrombophilia due to histidine-rich glycoprotein deficiency (THPH11). A hemostatic disorder characterized by a tendency to thrombosis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: plasma membrane; extracellular region

Molecular Function: heparan sulfate proteoglycan binding; serine-type endopeptidase inhibitor activity; heparin binding; protein binding; zinc ion binding; metal ion binding; heme binding; immunoglobulin binding; cysteine protease inhibitor activity; receptor binding

Biological Process: platelet activation; positive regulation of apoptosis; positive regulation of immune response to tumor cell; negative regulation of cell adhesion; chemotaxis; negative regulation of blood vessel endothelial cell migration; response to organic cyclic substance; negative regulation of cell proliferation; negative regulation of angiogenesis; fibrinolysis; platelet degranulation; negative regulation of fibrinolysis; positive regulation of focal adhesion formation; regulation of gene expression; regulation of actin cytoskeleton organization and biogenesis; regulation of blood coagulation; regulation of protein complex assembly; negative regulation of cell growth; angiogenesis; blood coagulation; defense response to fungus; regulation of peptidyl-tyrosine phosphorylation; negative regulation of cell adhesion mediated by integrin

Disease: Thrombophilia Due To Histidine-rich Glycoprotein Deficiency
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 Research Articles on HRG    1. HRG does not exhibit the broad interactive properties that have been reported previously, suggesting that copurification of HRG-binding partners or other impurities are responsible for some of the reported functional properties.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HRG recombinant proteinPathways associated with HRG recombinant protein
 Reference Product  PubMed Publications
 AHSG recombinant protein  >4 publications with HRG and AHSG
 THBS1 recombinant protein  >2 publications with HRG and THBS1
 FCGR1A recombinant protein  >1 publications with HRG and FCGR1A
 Products by Pathway  Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with HRG recombinant proteinOrgans/Tissues associated with HRG recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >191 publications with HRG and Neoplasms
 Breast Neoplasms Antibodies  >126 publications with HRG and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >33 publications with HRG and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >18 publications with HRG and Disease Models, Animal
 Thrombosis Antibodies  >18 publications with HRG and Thrombosis
 Nervous System Diseases Antibodies  >17 publications with HRG and Nervous System Diseases
 Adenocarcinoma Antibodies  >16 publications with HRG and Adenocarcinoma
 Heart Diseases Antibodies  >15 publications with HRG and Heart Diseases
 Necrosis Antibodies  >13 publications with HRG and Necrosis
 Liver Diseases Antibodies  >12 publications with HRG and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >25 publications with HRG and Liver
 Lung Antibodies  >15 publications with HRG and Lung
 Mammary Gland Antibodies  >15 publications with HRG and Mammary Gland
 Kidney Antibodies  >14 publications with HRG and Kidney
 Embryonic Tissue Antibodies  >8 publications with HRG and Embryonic Tissue
 Thymus Antibodies  >1 publications with HRG and Thymus
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