NP_001299582.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,890 Da
NCBI Official Full Name
histone H2B type 1-K
NCBI Official Synonym Full Names
histone cluster 1 H2B family member k
NCBI Protein Information
histone H2B type 1-K
UniProt Protein Name
Histone H2B type 1-K
UniProt Synonym Protein Names
HIRA-interacting protein 1
UniProt Synonym Gene Names
NCBI Summary for HIST1H2BK
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
UniProt Comments for HIST1H2BK
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Research Articles on HIST1H2BK
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Products associated with HIST1H2BK recombinant protein
Pathways associated with HIST1H2BK recombinant protein
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