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SETD7 recombinant protein :: Histone-lysine N-methyltransferase SETD7 (SETD7) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS7095426
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $660 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $885 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $975 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Histone-lysine N-methyltransferase SETD7 (SETD7), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Histone-lysine N-methyltransferase SETD7 (SETD7), partial

 Product Synonym Names    Histone H3-K4 methyltransferase SETD7
 Product Gene Name   

SETD7 recombinant protein

[Similar Products]
 Product Synonym Gene Name    SETD7 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    110--366aa; Partial
 Sequence    YKDNIRHGVC WIYYPDGGSL VGEVNEDGEM TGEKIAYVYP DERTALYGKF IDGEMIEGKL ATLMSTEEGR PHFELMPGNS VYHFDKSTSS CISTNALLPD PYESERVYVA ESLISSAGEG LFSKVAVGPN TVMSFYNGVR ITHQEVDSRD WALNGNTLSL DEETVIDVPE PYNHVSKYCA SLGHKANHSF TPNCIYDMFV HPRFGPIKCI RTLRAVEADE ELTVAYGYDH SPPGKSGPEA PEWYQVELKA FQATQQK
 OMIM    AF448510 mRNA
 3D Structure    ModBase 3D Structure for Q8WTS6
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SETD7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SETD7 recombinant protein

   Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
 Product Categories/Family for SETD7 recombinant protein    Epigenetics and Nuclear Signaling
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 SDS-Page of SETD7 recombinant protein    SETD7 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for SETD7. It may not necessarily be applicable to this product.
 NCBI GI #    807201031
 NCBI GeneID    80854
 NCBI Accession #    NP_001293128.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001306199.1 [Other Products]
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 UniProt Primary Accession #    Q8WTS6 [Other Products]
 UniProt Secondary Accession #    Q0VAH3; Q4W5A9; Q9C0E6; B5WWL3 [Other Products]
 UniProt Related Accession #    Q8WTS6 [Other Products]
 Molecular Weight    48.7kDa [Similar Products]
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 NCBI Official Full Name    histone-lysine N-methyltransferase SETD7 isoform 2
 NCBI Official Synonym Full Names    SET domain containing lysine methyltransferase 7
 NCBI Official Symbol    SETD7 [Similar Products]
 NCBI Official Synonym Symbols   
KMT7; SET7; SET9; SET7/9
[Similar Products]
 NCBI Protein Information    histone-lysine N-methyltransferase SETD7
 UniProt Protein Name    Histone-lysine N-methyltransferase SETD7
 UniProt Synonym Protein Names   
Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9
 Protein Family    Histone-lysine N-methyltransferase
 UniProt Gene Name    SETD7 [Similar Products]
 UniProt Synonym Gene Names    KIAA1717; KMT7; SET7; SET9; H3-K4-HMTase SETD7 [Similar Products]
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 UniProt Comments for SETD7    Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
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Product References and Citations for SETD7 recombinant protein

   "Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation." Nishioka K., Chuikov S., Sarma K., Erdjument-Bromage H., Allis C.D., Tempst P., Reinberg D. Genes Dev. 16:479-489(2002)
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 Research Articles on SETD7    1. the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SETD7 recombinant proteinPathways associated with SETD7 recombinant protein
 Reference Product  PubMed Publications
 SUV39H1 recombinant protein  >7 publications with SETD7 and SUV39H1
 DNMT1 recombinant protein  >7 publications with SETD7 and DNMT1
 RELA recombinant protein  >5 publications with SETD7 and RELA
 SIRT1 recombinant protein  >3 publications with SETD7 and SIRT1
 TAF10 recombinant protein  >2 publications with SETD7 and TAF10
 FOXO3 recombinant protein  >2 publications with SETD7 and FOXO3
 TP53 recombinant protein  >1 publications with SETD7 and TP53
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Histone Modifications Pathway antibodies  Histone Modifications Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram
Diseases associated with SETD7 recombinant proteinOrgans/Tissues associated with SETD7 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with SETD7 and Inflammation
 Hyperglycemia Antibodies  >7 publications with SETD7 and Hyperglycemia
 Necrosis Antibodies  >4 publications with SETD7 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >3 publications with SETD7 and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >3 publications with SETD7 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >2 publications with SETD7 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >2 publications with SETD7 and Kidney Diseases
 Prostatic Neoplasms Antibodies  >2 publications with SETD7 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >2 publications with SETD7 and Prostatic Diseases
 Lung Diseases Antibodies  >2 publications with SETD7 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >12 publications with SETD7 and Vascular
 Heart Antibodies  >10 publications with SETD7 and Heart
 Blood Antibodies  >9 publications with SETD7 and Blood
 Liver Antibodies  >6 publications with SETD7 and Liver
 Muscle Antibodies  >5 publications with SETD7 and Muscle
 Brain Antibodies  >5 publications with SETD7 and Brain
 Lung Antibodies  >4 publications with SETD7 and Lung
 Kidney Antibodies  >4 publications with SETD7 and Kidney
 Connective Tissue Antibodies  >3 publications with SETD7 and Connective Tissue
 Pancreas Antibodies  >3 publications with SETD7 and Pancreas
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