NP_001292869.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,490 Da
NCBI Official Full Name
homeobox protein ARX
NCBI Official Synonym Full Names
aristaless related homeobox
NCBI Official Synonym Symbols
NCBI Protein Information
homeobox protein ARX
UniProt Protein Name
Homeobox protein ARX
UniProt Synonym Protein Names
Aristaless-related homeobox
NCBI Summary for Arx
This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
UniProt Comments for Arx
Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate ().
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Disclaimer
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Products associated with Arx recombinant protein
Diseases associated with Arx recombinant protein
Disease Name |
Pubmed Publications |
Mental Retardation, X-Linked, With Or Without Seizures, Arx-Related Antibodies |
>88 publications with Arx and Mental Retardation, X-Linked, With Or Without Seizures, Arx-Related |
Neurobehavioral Manifestations Antibodies |
>81 publications with Arx and Neurobehavioral Manifestations |
Abnormalities, Multiple Antibodies |
>25 publications with Arx and Abnormalities, Multiple |
Disease Models, Animal Antibodies |
>20 publications with Arx and Disease Models, Animal |
Neurodegenerative Diseases Antibodies |
>9 publications with Arx and Neurodegenerative Diseases |
Lissencephaly, X-Linked, 2 Antibodies |
>8 publications with Arx and Lissencephaly, X-Linked, 2 |
Fibrosis Antibodies |
>5 publications with Arx and Fibrosis |
Learning Disorders Antibodies |
>5 publications with Arx and Learning Disorders |
Necrosis Antibodies |
>3 publications with Arx and Necrosis |
Kidney Diseases Antibodies |
>3 publications with Arx and Kidney Diseases |
Organs/Tissues associated with Arx recombinant protein
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