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Nkx2-2 recombinant protein :: Homeobox protein Nkx-2.2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717971
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,025 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,255 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,255 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,585 +1 FREE 8GB USB
1 mg (Yeast)  /  $2,050 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,050 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Homeobox protein Nkx-2.2 (Nkx2-2), Recombinant Protein

 Also Known As   

Recombinant Mouse Homeobox protein Nkx-2.2

 Product Synonym Names    Homeobox protein NK-2 homolog B
 Product Gene Name   

Nkx2-2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-273
 Sequence    MSLTNTKTGF SVKDILDLPD TNDEDGSVAE GPEEESEGPE PAKRAGPLGQ GALDAVQSLP LKSPFYDSSD NPYTRWLAST EGLQYSLHGL AASAPPQDSS SKSPEPSADE SPDNDKETQG GGGDAGKKRK RRVLFSKAQT YELERRFRQQ RYLSAPEREH LASLIRLTPT QVKIWFQNHR YKMKRARAEK GMEVTPLPSP RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ SLQHMQYNAQ YSSASTPQYP TAHPLVQAQQ WTW
 3D Structure    ModBase 3D Structure for P42586
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Nkx2-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Nkx2-2 recombinant protein

   Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter.
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 SDS-Page of Nkx2-2 recombinant protein    Nkx2-2 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Nkx2-2. It may not necessarily be applicable to this product.
 NCBI GI #    6754860
 NCBI GeneID    18088
 NCBI Accession #    NP_035049.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010919.2 [Other Products]
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 UniProt Primary Accession #    P42586 [Other Products]
 UniProt Related Accession #    P42586 [Other Products]
 Molecular Weight    46.11kD
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 NCBI Official Full Name    homeobox protein Nkx-2.2 isoform 1
 NCBI Official Synonym Full Names    NK2 homeobox 2
 NCBI Official Symbol    Nkx2-2 [Similar Products]
 NCBI Official Synonym Symbols   
Nkx2.2; tinman; Nkx-2.2
[Similar Products]
 NCBI Protein Information    homeobox protein Nkx-2.2
 UniProt Protein Name    Homeobox protein Nkx-2.2
 UniProt Synonym Protein Names   
Homeobox protein NK-2 homolog B
 Protein Family    Homeobox protein
 UniProt Gene Name    Nkx2-2 [Similar Products]
 UniProt Synonym Gene Names    Nkx-2.2; Nkx2b [Similar Products]
 UniProt Entry Name    NKX22_MOUSE
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 UniProt Comments for Nkx2-2    NKX2-2: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family.

Protein type: Cell development/differentiation; Transcription factor

Cellular Component: intracellular; nucleus

Molecular Function: chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: astrocyte differentiation; cell development; cell differentiation; endocrine pancreas development; gut development; multicellular organismal development; negative regulation of neuron differentiation; nervous system development; neuron fate specification; oligodendrocyte development; positive regulation of cell differentiation; positive regulation of neuron differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell differentiation; regulation of transcription, DNA-dependent; smoothened signaling pathway; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell differentiation; spinal cord oligodendrocyte cell fate specification; transcription, DNA-dependent
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Product References and Citations for Nkx2-2 recombinant protein

   "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain." Price M., Lazzaro D., Pohl T., Mattei M.-G., Ruether U., Olivo J.-C., Duboule D., di Lauro R. Neuron 8:241-255(1992)
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 Research Articles on Nkx2-2    1. The study demonstrates a previously unrecognized mechanism that controls insulin expression through c-Abl-regulated NKx2.2 and GLUT2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Nkx2-2 recombinant proteinPathways associated with Nkx2-2 recombinant protein
 Reference Product  PubMed Publications
 Pax6 recombinant protein  >83 publications with Nkx2-2 and Pax6
 Olig2 recombinant protein  >72 publications with Nkx2-2 and Olig2
 Neurog3 recombinant protein  >32 publications with Nkx2-2 and Neurog3
 Neurod1 recombinant protein  >27 publications with Nkx2-2 and Neurod1
 Foxa2 recombinant protein  >24 publications with Nkx2-2 and Foxa2
 Fgf2 recombinant protein  >6 publications with Nkx2-2 and Fgf2
 Tle3 recombinant protein  >3 publications with Nkx2-2 and Tle3
 Tle1 recombinant protein  >2 publications with Nkx2-2 and Tle1
 Tle4 recombinant protein  >2 publications with Nkx2-2 and Tle4
 Ins1 recombinant protein  >2 publications with Nkx2-2 and Ins1
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dopminergic Neurogenesis Pathway antibodies  Dopminergic Neurogenesis Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Regulation Of Beta-cell Development Pathway antibodies  Regulation Of Beta-cell Development Pathway Diagram
 Regulation Of Gene Expression In Endocrine-committed (NEUROG3+) Progenitor Cells Pathway antibodies  Regulation Of Gene Expression In Endocrine-committed (NEUROG3+) Progenitor Cells Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with Nkx2-2 recombinant proteinOrgans/Tissues associated with Nkx2-2 recombinant protein
 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >27 publications with Nkx2-2 and Diabetes Mellitus
 Carcinoma Antibodies  >12 publications with Nkx2-2 and Carcinoma
 Immune System Diseases Antibodies  >10 publications with Nkx2-2 and Immune System Diseases
 Death Antibodies  >9 publications with Nkx2-2 and Death
 Pancreatic Neoplasms Antibodies  >6 publications with Nkx2-2 and Pancreatic Neoplasms
 Lung Diseases Antibodies  >5 publications with Nkx2-2 and Lung Diseases
 Liver Diseases Antibodies  >4 publications with Nkx2-2 and Liver Diseases
 Inflammation Antibodies  >3 publications with Nkx2-2 and Inflammation
 Lung Neoplasms Antibodies  >3 publications with Nkx2-2 and Lung Neoplasms
 Hyperplasia Antibodies  >2 publications with Nkx2-2 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >140 publications with Nkx2-2 and Pancreas
 Brain Antibodies  >95 publications with Nkx2-2 and Brain
 Spinal Cord Antibodies  >79 publications with Nkx2-2 and Spinal Cord
 Embryonic Tissue Antibodies  >78 publications with Nkx2-2 and Embryonic Tissue
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