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HOMER1 recombinant protein :: Homer protein homolog 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717416
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Homer protein homolog 1 (HOMER1), Recombinant Protein

 Also Known As   

Recombinant Human Homer protein homolog 1

 Product Gene Name   

HOMER1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    SYN47 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-354aa; Full Length
 Sequence    MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN AVHTHKTELN QTIQELEETL KLKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL LECS
 OMIM    604798
 3D Structure    ModBase 3D Structure for Q86YM7
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HOMER1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HOMER1 recombinant protein

   Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
 Product Categories/Family for HOMER1 recombinant protein    Neuroscience
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 SDS-PAGE of HOMER1 recombinant protein    HOMER1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for HOMER1. It may not necessarily be applicable to this product.
 NCBI GI #    459215038
 NCBI GeneID    9456
 NCBI Accession #    NP_001264006.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001277077.1 [Other Products]
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 UniProt Primary Accession #    Q86YM7 [Other Products]
 UniProt Secondary Accession #    O96003; Q86YM5; B2R688 [Other Products]
 UniProt Related Accession #    Q86YM7 [Other Products]
 Molecular Weight    44.4kD
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 NCBI Official Full Name    homer protein homolog 1 isoform 2
 NCBI Official Synonym Full Names    homer scaffolding protein 1
 NCBI Official Symbol    HOMER1 [Similar Products]
 NCBI Official Synonym Symbols   
HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
[Similar Products]
 NCBI Protein Information    homer protein homolog 1
 UniProt Protein Name    Homer protein homolog 1
 Protein Family    Homer protein
 UniProt Gene Name    HOMER1 [Similar Products]
 UniProt Synonym Gene Names    SYN47; Homer-1 [Similar Products]
 UniProt Entry Name    HOME1_HUMAN
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 NCBI Summary for HOMER1    This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HOMER1    HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: apical part of cell; axon; cell junction; costamere; postsynaptic membrane; Z disc

Molecular Function: metabotropic glutatmate receptor binding; protein binding

Biological Process: behavioral response to cocaine; chemical homeostasis within a tissue; metabotropic glutamate receptor, phospholipase C activating pathway; positive regulation of calcium ion transport; positive regulation of signal transduction; response to calcium ion; skeletal muscle contraction; skeletal muscle fiber development; synaptic transmission
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Product References and Citations for HOMER1 recombinant protein

   Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., Worley P.F.Neuron 21:707-716(1998)
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 Research Articles on HOMER1    1. The mRNA levels of Homer1, IL-1beta, and TNF-alpha in coronary artery disease patients were significantly higher than those in the control group, but not Homer2 and Homer3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HOMER1 recombinant proteinPathways associated with HOMER1 recombinant protein
 Reference Product  PubMed Publications
 GRM5 recombinant protein  >10 publications with HOMER1 and GRM5
 RYR1 recombinant protein  >4 publications with HOMER1 and RYR1
 SHANK1 recombinant protein  >2 publications with HOMER1 and SHANK1
 GRIA1 recombinant protein  >1 publications with HOMER1 and GRIA1
 GRM1 recombinant protein  >1 publications with HOMER1 and GRM1
 Products by Pathway  Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
Diseases associated with HOMER1 recombinant proteinOrgans/Tissues associated with HOMER1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >21 publications with HOMER1 and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with HOMER1 and Brain Diseases
 Pain Antibodies  >8 publications with HOMER1 and Pain
 Disease Models, Animal Antibodies  >7 publications with HOMER1 and Disease Models, Animal
 Learning Disorders Antibodies  >5 publications with HOMER1 and Learning Disorders
 Cocaine-Related Disorders Antibodies  >5 publications with HOMER1 and Cocaine-Related Disorders
 Movement Disorders Antibodies  >4 publications with HOMER1 and Movement Disorders
 Depressive Disorder Antibodies  >4 publications with HOMER1 and Depressive Disorder
 Inflammation Antibodies  >3 publications with HOMER1 and Inflammation
 Memory Disorders Antibodies  >3 publications with HOMER1 and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >64 publications with HOMER1 and Brain
 Nerve Antibodies  >17 publications with HOMER1 and Nerve
 Muscle Antibodies  >10 publications with HOMER1 and Muscle
 Blood Antibodies  >3 publications with HOMER1 and Blood
 Heart Antibodies  >2 publications with HOMER1 and Heart
 Eye Antibodies  >2 publications with HOMER1 and Eye
 Kidney Antibodies  >2 publications with HOMER1 and Kidney
 Salivary Gland Antibodies  >1 publications with HOMER1 and Salivary Gland
 Adrenal Gland Antibodies  >1 publications with HOMER1 and Adrenal Gland
 Liver Antibodies  >1 publications with HOMER1 and Liver
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