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Add To Compare List Htt recombinant protein :: Huntingtin (Htt) Recombinant Protein Catalog # MBS961888 Unit / Price 0.02 mg (E-Coli) / $750 +1 FREE 8GB USB 0.1 mg (E-Coli) / $895 +1 FREE 8GB USB 0.02 mg (Yeast) / $910 +1 FREE 8GB USB 0.1 mg (Yeast) / $1,065 +1 FREE 8GB USB 0.02 mg (Baculovirus) / $1,125 +1 FREE 8GB USB 0.02 mg (Mammalian-Cell) / $1,390 +1 FREE 8GB USB 1 mg (E-Coli) / $1,590 +1 FREE 8GB USB 0.1 mg (Baculovirus) / $1,610 +2 FREE 8GB USB 1 mg (Yeast) / $2,090 +2 FREE 8GB USB 0.1 mg (Mammalian-Cell) / $2,190 +2 FREE 8GB USB 1 mg (Baculovirus) / $3,155 +3 FREE 8GB USB 0.5 mg (Mammalian-Cell) / $5,880 +7 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Huntingtin (Htt), Recombinant Protein Popular Item Full Product Name Recombinant Mouse Huntingtin (Htt) , partial Product Gene Name Htt recombinant protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP MBS961888 COA COA PDF Sequence Positions 427-660. Partial Sequence EEALEDDSES RSDVSSSAFA ASVKSEIGGE LAASSGVSTP GSVGHDIITE QPRSQHTLQA DSVDLSGCDL TSAATDGDEE DILSHSSSQF SAVPSDPAMD LNDGTQASSP ISDSSQTTTE GPDSAVTPSD SSEIVLDGAD SQYLGMQIGQ PQEDDEEGAA GVLSGEVSDV FRNSSLALQQ AHLLERMGHS RQPSDSSIDK YVTRDEVAEA SDPESKPCRI KGDIGQPNDD DSAP 3D Structure ModBase 3D Structure for P42859 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Mouse Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of Htt recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Htt recombinant protein Huntingtin is a disease gene linked to Huntington s disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington s disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5 UTR that inhibits expression of the huntingtin gene product through translational repression. NCBI/Uniprot data below describe general gene information for Htt. It may not necessarily be applicable to this product. NCBI GI # 1708161 NCBI GeneID 15194 NCBI Accession # P42859.2 [Other Products] UniProt Primary Accession # P42859 [Other Products] UniProt Related Accession # P42859[Other Products] Molecular Weight 290,701 Da TOP NCBI Official Full Name Huntingtin NCBI Official Synonym Full Names huntingtin NCBI Official Symbol Htt [Similar Products] NCBI Official Synonym Symbols Hd; Hdh; IT15; AI256365; C430023I11Rik [Similar Products] NCBI Protein Information huntingtin UniProt Protein Name Huntingtin UniProt Synonym Protein Names Huntington disease protein homolog; HD protein homolog Protein Family HD protein UniProt Gene Name Htt [Similar Products] UniProt Synonym Gene Names Hd; Hdh; HD protein homolog [Similar Products] TOP TOP UniProt Comments for Htt May play a role in microtubule-mediated transport or vesicle function. Research Articles on Htt 1. This study demonstrates that loss of Htt function during neural development leads to HD-like neurological abnormalities in mice. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. 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TOP Products associated with Htt recombinant protein Reference Product PubMed Publications Drd2 recombinant protein >24 publications with Htt and Drd2 Trp53 recombinant protein >13 publications with Htt and Trp53 Crebbp recombinant protein >12 publications with Htt and Crebbp Zdhhc17 recombinant protein >12 publications with Htt and Zdhhc17 Optn recombinant protein >6 publications with Htt and Optn Pacsin1 recombinant protein >6 publications with Htt and Pacsin1 Tcerg1 recombinant protein >4 publications with Htt and Tcerg1 Itpr1 recombinant protein >3 publications with Htt and Itpr1 Pathways associated with Htt recombinant protein Products by Pathway Pathway Diagram EGFR1 Signaling Pathway antibodies EGFR1 Signaling Pathway Diagram Huntington's Disease Pathway antibodies Huntington's Disease Pathway Diagram Huntington's Disease Pathway antibodies Huntington's Disease Pathway Diagram XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram Diseases associated with Htt recombinant protein Disease Name Pubmed Publications Brain Diseases Antibodies >440 publications with Htt and Brain Diseases Huntington Disease Antibodies >438 publications with Htt and Huntington Disease Neurodegenerative Diseases Antibodies >429 publications with Htt and Neurodegenerative Diseases Movement Disorders Antibodies >392 publications with Htt and Movement Disorders Cognition Disorders Antibodies >388 publications with Htt and Cognition Disorders Death Antibodies >167 publications with Htt and Death Anxiety Disorders Antibodies >137 publications with Htt and Anxiety Disorders Substance-Related Disorders Antibodies >81 publications with Htt and Substance-Related Disorders Drug Toxicity Antibodies >74 publications with Htt and Drug Toxicity Nerve Degeneration Antibodies >64 publications with Htt and Nerve Degeneration Organs/Tissues associated with Htt recombinant protein Organ/Tissue Name Pubmed Publications Brain Antibodies >1808 publications with Htt and Brain Embryonic Tissue Antibodies >109 publications with Htt and Embryonic Tissue Heart Antibodies >68 publications with Htt and Heart Liver Antibodies >57 publications with Htt and Liver Eye Antibodies >55 publications with Htt and Eye Lung Antibodies >43 publications with Htt and Lung Kidney Antibodies >37 publications with Htt and Kidney Skin Antibodies >33 publications with Htt and Skin Bone Antibodies >32 publications with Htt and Bone Spinal Cord Antibodies >21 publications with Htt and Spinal Cord TOP © 2006-24 MyBioSource.com. 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