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HYAL1 recombinant protein :: Hyaluronidase-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1465303
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,060 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,305 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,345 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,930 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,980 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,545 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hyaluronidase-1 (HYAL1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Hyaluronidase-1

 Product Synonym Names    Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1
 Product Gene Name   

HYAL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1465303 COA    COA PDF
 Sequence Positions    22-435aa; Full Length
 Sequence    FRGPLLPNRP FTTVWNANTQ WCLERHGVDV DVSVFDVVAN PGQTFRGPDM TIFYSSQLGT YPYYTPTGEP VFGGLPQNAS LIAHLARTFQ DILAAIPAPD FSGLAVIDWE AWRPRWAFNW DTKDIYRQRS RALVQAQHPD WPAPQVEAVA QDQFQGAARA WMAGTLQLGR ALRPRGLWGF YGFPDCYNYD FLSPNYTGQC PSGIRAQNDQ LGWLWGQSRA LYPSIYMPAV LEGTGKSQMY VQHRVAEAFR VAVAAGDPNL PVLPYVQIFY DTTNHFLPLD ELEHSLGESA AQGAAGVVLW VSWENTRTKE SCQAIKEYMD TTLGPFILNV TSGALLCSQA LCSGHGRCVR RTSHPKALLL LNPASFSIQL TPGGGPLSLR GALSLEDQAQ MAVEFKCRCY PGWQAPWCER KSMW
 OMIM    601492
 3D Structure    ModBase 3D Structure for Q12794
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HYAL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HYAL1 recombinant protein

   May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
 Product Categories/Family for HYAL1 recombinant protein    Cancer
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 SDS-PAGE of HYAL1 recombinant protein    HYAL1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for HYAL1. It may not necessarily be applicable to this product.
 NCBI GI #    24497562
 NCBI GeneID    3373
 NCBI Accession #    NP_149349.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_033159.3 [Other Products]
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 UniProt Primary Accession #    Q12794 [Other Products]
 UniProt Secondary Accession #    Q6FH23; Q6PIZ6; Q7KYU2; Q7LE34; Q8NFK5; Q8NFK6; Q8NFK7; Q8NFK8; Q8NFK9; Q93013; Q9UKD5 [Other Products]
 UniProt Related Accession #    Q12794 [Other Products]
 Molecular Weight    50.2kD
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 NCBI Official Full Name    hyaluronidase-1 isoform 1
 NCBI Official Synonym Full Names    hyaluronoglucosaminidase 1
 NCBI Official Symbol    HYAL1 [Similar Products]
 NCBI Official Synonym Symbols   
MPS9; NAT6; LUCA1; HYAL-1
[Similar Products]
 NCBI Protein Information    hyaluronidase-1
 UniProt Protein Name    Hyaluronidase-1
 UniProt Synonym Protein Names   
Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1
 Protein Family    Hyaluronidase
 UniProt Gene Name    HYAL1 [Similar Products]
 UniProt Synonym Gene Names    LUCA1; Hyal-1; LuCa-1 [Similar Products]
 UniProt Entry Name    HYAL1_HUMAN
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 NCBI Summary for HYAL1    This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HYAL1    HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Glycan Metabolism - glycosaminoglycan degradation; Secreted, signal peptide; Hydrolase; EC 3.2.1.35

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytoplasm; cytoplasmic vesicle; extracellular space; lysosomal lumen; lysosome

Molecular Function: hyaluronan synthase activity; hyalurononglucosaminidase activity; transcription factor binding; viral receptor activity

Biological Process: carbohydrate metabolic process; cartilage development; chondroitin sulfate catabolic process; chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; hyaluronan biosynthetic process; hyaluronan catabolic process; hyaluronan metabolic process; inflammatory response; negative regulation of cell growth; positive regulation of angiogenesis; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of growth; response to antibiotic; response to reactive oxygen species; response to virus

Disease: Mucopolysaccharidosis, Type Ix
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Product References and Citations for HYAL1 recombinant protein

   Purification, cloning, and expression of human plasma hyaluronidase.Frost G.I., Csoka A.B., Wong T., Stern R.Biochem. Biophys. Res. Commun. 236:10-15(1997)
Regulation of hyaluronidase activity by alternative mRNA splicing.Lokeshwar V.B., Schroeder G.L., Carey R.I., Soloway M.S., Iida N.J. Biol. Chem. 277:33654-33663(2002)
Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis.Chao K.L., Muthukumar L., Herzberg O.Biochemistry 46:6911-6920(2007)
Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX.Triggs-Raine B., Salo T.J., Zhang H., Wicklow B.A., Natowicz M.R.Proc. Natl. Acad. Sci. U.S.A. 96:6296-6300(1999)
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 Research Articles on HYAL1    1. Study showed that reduced HYAL1 expression was associated with endometrial carcinoma aggressiveness, which further supported the role of hyaluronan degradation in cancer progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HYAL1 recombinant proteinDiseases associated with HYAL1 recombinant protein
 Products by Pathway  Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Degradation Pathway antibodies  Chondroitin Sulfate Degradation Pathway Diagram
 Chondroitin Sulfate Degradation Pathway antibodies  Chondroitin Sulfate Degradation Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Dermatan Sulfate Degradation Pathway antibodies  Dermatan Sulfate Degradation Pathway Diagram
 Dermatan Sulfate Degradation Pathway antibodies  Dermatan Sulfate Degradation Pathway Diagram
 Glycosaminoglycan Degradation Pathway antibodies  Glycosaminoglycan Degradation Pathway Diagram
 Glycosaminoglycan Degradation Pathway antibodies  Glycosaminoglycan Degradation Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hyaluronan Metabolism Pathway antibodies  Hyaluronan Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >12 publications with HYAL1 and Lung Neoplasms
 Inflammation Antibodies  >11 publications with HYAL1 and Inflammation
 Hyaluronidase Deficiency Antibodies  >11 publications with HYAL1 and Hyaluronidase Deficiency
 Necrosis Antibodies  >8 publications with HYAL1 and Necrosis
 Neoplasms, Experimental Antibodies  >6 publications with HYAL1 and Neoplasms, Experimental
 Immune System Diseases Antibodies  >5 publications with HYAL1 and Immune System Diseases
 Urinary Bladder Neoplasms Antibodies  >5 publications with HYAL1 and Urinary Bladder Neoplasms
 Kidney Diseases Antibodies  >4 publications with HYAL1 and Kidney Diseases
 Liver Neoplasms Antibodies  >2 publications with HYAL1 and Liver Neoplasms
 Hyperplasia Antibodies  >2 publications with HYAL1 and Hyperplasia
Organs/Tissues associated with HYAL1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with HYAL1 and Blood
 Lung Antibodies  >16 publications with HYAL1 and Lung
 Kidney Antibodies  >14 publications with HYAL1 and Kidney
 Prostate Antibodies  >13 publications with HYAL1 and Prostate
 Bladder Antibodies  >8 publications with HYAL1 and Bladder
 Vascular Antibodies  >7 publications with HYAL1 and Vascular
 Liver Antibodies  >7 publications with HYAL1 and Liver
 Muscle Antibodies  >6 publications with HYAL1 and Muscle
 Brain Antibodies  >4 publications with HYAL1 and Brain
 Connective Tissue Antibodies  >4 publications with HYAL1 and Connective Tissue
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