NP_003764.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51.3 kDa
NCBI Official Full Name
hyaluronidase-2
NCBI Official Synonym Full Names
hyaluronoglucosaminidase 2
NCBI Official Synonym Symbols
NCBI Protein Information
hyaluronidase-2
UniProt Protein Name
Hyaluronidase-2
UniProt Synonym Protein Names
Hyaluronoglucosaminidase-2; Lung carcinoma protein 2; LuCa-2
UniProt Synonym Gene Names
NCBI Summary for HYAL2
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]
UniProt Comments for HYAL2
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Research Articles on HYAL2
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Products associated with HYAL2 recombinant protein
Pathways associated with HYAL2 recombinant protein
Diseases associated with HYAL2 recombinant protein
Organs/Tissues associated with HYAL2 recombinant protein
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