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HSD17B11 recombinant protein :: Hydroxysteroid Dehydrogenase 11 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144293 HSD17B11 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hydroxysteroid Dehydrogenase 11 (HSD17B11), Recombinant Protein

 Also Known As   

Recombinant Human Hydroxysteroid (17-beta) Dehydrogenase 11

 Product Synonym Names    HSD17B11 Human; Hydroxysteroid (17-beta) Dehydrogenase 11 Human Recombinant; Estradiol 17-beta-dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2; HSD17B11; DHRS8; PAN1B; SDR16C2; 17BHSD11
 Product Gene Name   

HSD17B11 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MESFVK LFIP KRRKSVTGEI VLITGAGHGI GRLTAYEFAK LKSKLVLWDI NKHGLEETAA KCKGLGAKVH TFVVDCSNRE DIYSSAKKVK AEIGDVSILV NNAGVVYTSD LFATQDPQIE KTFEVNVLAH FWTTKAFLPA MTKNNHGHIV TVASAAGHVS VPFLLAYCSS KFAAVGFHKT LTDELAALQI TGVKTTCLCP NFVNTGFIKN PSTSLGPTLE PEEVVNRLMH GILTEQKMIF IPSSIAFLTT LERILPERFL AVLKQKI
 OMIM    612831
 3D Structure    ModBase 3D Structure for Q8NBQ5
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The HSD17B11 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    HSD17B11 should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of HSD17B11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HSD17B11 recombinant protein

   Description: HSD17B11 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 287 amino acids (20-285 a.a.) and having a molecular mass of 31.4kDa. The HSD17B11 is purified by proprietary chromatographic techniques.

Introduction: Dehydrogenase/reductase SDR family member 8 (HSD17B11) is a member of the HSD17B family of proteins, which regulate the availability of steroids within various tissues throughout the body. HSD17B11 is widely expressed with the highest levels found in the retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart as well as in steroidogenic cells. HSD17B11 converts androstan-3-?,17-?-diol (3-?-diol) to androsterone, suggesting it may participate in androgen metabolism during steroidogenesis.
 Product Categories/Family for HSD17B11 recombinant protein    ENZYMES; Enzymes; Dehydrogenase
NCBI/Uniprot data below describe general gene information for HSD17B11. It may not necessarily be applicable to this product.
 NCBI GI #    613410229
 NCBI GeneID    51170
 NCBI Accession #    NP_057329.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_016245.4 [Other Products]
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 UniProt Primary Accession #    Q8NBQ5 [Other Products]
 UniProt Secondary Accession #    Q96HF6; Q9UKU4 [Other Products]
 UniProt Related Accession #    Q8NBQ5 [Other Products]
 Molecular Weight    32,936 Da
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 NCBI Official Full Name    estradiol 17-beta-dehydrogenase 11
 NCBI Official Synonym Full Names    hydroxysteroid (17-beta) dehydrogenase 11
 NCBI Official Symbol    HSD17B11 [Similar Products]
 NCBI Official Synonym Symbols   
DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI
[Similar Products]
 NCBI Protein Information    estradiol 17-beta-dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase type XI; CTCL tumor antigen HD-CL-03; CTCL-associated antigen HD-CL-03; cutaneous T-cell lymphoma-associated antigen HD-CL-03; dehydrogenase/reductase SDR family member 8; retinal short-chain dehydrogenase/reductase 2; short chain dehydrogenase/reductase family 16C, member 2
 UniProt Protein Name    Estradiol 17-beta-dehydrogenase 11
 UniProt Synonym Protein Names   
17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2
 Protein Family    Estradiol 17 beta-dehydrogenase
 UniProt Gene Name    HSD17B11 [Similar Products]
 UniProt Synonym Gene Names    DHRS8; PAN1B; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-HSD XI; 17betaHSDXI; CTCL-associated antigen HD-CL-03; retSDR2 [Similar Products]
 UniProt Entry Name    DHB11_HUMAN
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 NCBI Summary for HSD17B11    Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
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 UniProt Comments for HSD17B11    HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: EC 1.1.1.62; Secreted; Oxidoreductase; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: cytoplasm; extracellular region; lipid particle

Molecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activity

Biological Process: steroid biosynthetic process; androgen catabolic process
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 Research Articles on HSD17B11    1. hydroxysteroid (17-beta) dehydrogenase 11 transcription in prostate cancer cells is regulated by Sp1 transcription factor and C-EBP alpha
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HSD17B11 recombinant proteinDiseases associated with HSD17B11 recombinant protein
 Products by Pathway  Pathway Diagram
 Estradiol Biosynthesis I Pathway antibodies  Estradiol Biosynthesis I Pathway Diagram
 Superpathway Of Steroid Hormone Biosynthesis antibodies  Superpathway Of Steroid Hormone Biosynthesis Diagram
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >2 publications with HSD17B11 and Hypertension
 Prostatic Diseases Antibodies  >2 publications with HSD17B11 and Prostatic Diseases
 Neoplasms, Experimental Antibodies  >1 publications with HSD17B11 and Neoplasms, Experimental
Organs/Tissues associated with HSD17B11 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with HSD17B11 and Lung
 Blood Antibodies  >2 publications with HSD17B11 and Blood
 Liver Antibodies  >2 publications with HSD17B11 and Liver
 Prostate Antibodies  >2 publications with HSD17B11 and Prostate
 Bone Antibodies  >1 publications with HSD17B11 and Bone
 Embryonic Tissue Antibodies  >1 publications with HSD17B11 and Embryonic Tissue
 Adipose Tissue Antibodies  >1 publications with HSD17B11 and Adipose Tissue
 Ovary Antibodies  >1 publications with HSD17B11 and Ovary
 Muscle Antibodies  >1 publications with HSD17B11 and Muscle
 Trachea Antibodies  >1 publications with HSD17B11 and Trachea
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