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HIF1AN recombinant protein :: Hypoxia-Inducible Factor-1 Alpha Inhibitor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143743 HIF1AN recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hypoxia-Inducible Factor-1 Alpha Inhibitor (HIF1AN), Recombinant Protein

 Also Known As   

Recombinant Human Hypoxia-Inducible Factor-1 Alpha Inhibitor

 Product Synonym Names    HIF1AN Human; Hypoxia-Inducible Factor-1 Alpha Inhibitor Human Recombinant; FIH1; FIH-1; HIF1AN; Factor Inhibiting HIF1A; Hypoxia-inducible factor 1-alpha inhibitor; Hypoxia-inducible factor asparagine hydroxylase; Factor inhibiting HIF-1; FLJ20615; FLJ22027; DKFZp762F1811
 Product Gene Name   

HIF1AN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN.
 OMIM    606615
 3D Structure    ModBase 3D Structure for Q9NWT6
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    The protein solution contains 20mM Tris-HCl pH-8.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of HIF1AN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HIF1AN recombinant protein

   Description: HIF1AN Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids and having a molecular mass of 40.2 kDa. The HIF1AN is purified by proprietary chromatographic techniques.

Introduction: Overexpression of the HIF1AN is linked with tumor aggressiveness in pancreatic endocrine tumors. HIF1AN hydroxylates Notch ICD at two residues that are crucial for the function of Notch ICD as a transactivator within cells and during neurogenesis and myogenesis. HIF1AN is commonly expressed in invasive breast carcinoma. The hypoxic response and survival recommends that tumour regulation of HIF1AN is an additional important mechanism for HIF pathway activation. HIF1AN is an asparaginyl hydroxylase enzyme that controls the transcriptional activity of hypoxia-inducible factor. FIH1 is a part of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, FIH1 is protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1A C-terminal transactivation domain. In normoxia, the HIF1AN-mediated hydroxylation of the HIF1? transactivation domain which results in blockage of the HIF1A-p300/CBP interaction and represses transcriptional activity of HIF1A targeted genes.
 Product Categories/Family for HIF1AN recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Hypoxia-Inducible Factor
NCBI/Uniprot data below describe general gene information for HIF1AN. It may not necessarily be applicable to this product.
 NCBI GI #    148596936
 NCBI GeneID    55662
 NCBI Accession #    NP_060372.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_017902.2 [Other Products]
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 UniProt Primary Accession #    Q9NWT6 [Other Products]
 UniProt Secondary Accession #    Q5W147; Q969Q7; Q9NPV5; D3DR69 [Other Products]
 UniProt Related Accession #    Q9NWT6 [Other Products]
 Molecular Weight    40,285 Da
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 NCBI Official Full Name    hypoxia-inducible factor 1-alpha inhibitor
 NCBI Official Synonym Full Names    hypoxia inducible factor 1, alpha subunit inhibitor
 NCBI Official Symbol    HIF1AN [Similar Products]
 NCBI Official Synonym Symbols   
FIH1
[Similar Products]
 NCBI Protein Information    hypoxia-inducible factor 1-alpha inhibitor; FIH-1; factor inhibiting HIF-1; factor inhibiting HIF1; hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
 UniProt Protein Name    Hypoxia-inducible factor 1-alpha inhibitor
 UniProt Synonym Protein Names   
Factor inhibiting HIF-1; FIH-1; Hypoxia-inducible factor asparagine hydroxylase
 Protein Family    Hypoxia-inducible factor 1-alpha inhibitor
 UniProt Gene Name    HIF1AN [Similar Products]
 UniProt Synonym Gene Names    FIH1; FIH-1 [Similar Products]
 UniProt Entry Name    HIF1N_HUMAN
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 UniProt Comments for HIF1AN    HIF1AN: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A. Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4.

Protein type: EC 1.14.11.n4; Oxidoreductase; EC 1.14.11.30

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function: NF-kappaB binding; protein binding; protein homodimerization activity; oxygen sensor activity; zinc ion binding; carboxylic acid binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; cofactor binding; Notch binding

Biological Process: peptidyl-aspartic acid hydroxylation; transcription, DNA-dependent; negative regulation of Notch signaling pathway; peptidyl-asparagine hydroxylation; positive regulation of myoblast differentiation
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 Research Articles on HIF1AN    1. Data indicate that exosomal miR-135b directly suppressed its target factor-inhibiting hypoxia-inducible factor 1 (FIH-1) in endothelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HIF1AN recombinant proteinPathways associated with HIF1AN recombinant protein
 Reference Product  PubMed Publications
 HIF1A recombinant protein  >59 publications with HIF1AN and HIF1A
 VHL recombinant protein  >11 publications with HIF1AN and VHL
 VEGFA recombinant protein  >6 publications with HIF1AN and VEGFA
 MMP14 recombinant protein  >2 publications with HIF1AN and MMP14
 Products by Pathway  Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway antibodies  Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway Diagram
 Oxygen-dependent Asparagine Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway antibodies  Oxygen-dependent Asparagine Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway Diagram
 Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway antibodies  Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway Diagram
Diseases associated with HIF1AN recombinant proteinOrgans/Tissues associated with HIF1AN recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >11 publications with HIF1AN and Kidney Diseases
 Nervous System Diseases Antibodies  >6 publications with HIF1AN and Nervous System Diseases
 Inflammation Antibodies  >5 publications with HIF1AN and Inflammation
 Liver Diseases Antibodies  >5 publications with HIF1AN and Liver Diseases
 Breast Neoplasms Antibodies  >5 publications with HIF1AN and Breast Neoplasms
 Brain Diseases Antibodies  >4 publications with HIF1AN and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with HIF1AN and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >3 publications with HIF1AN and Disease Models, Animal
 Necrosis Antibodies  >3 publications with HIF1AN and Necrosis
 Heart Diseases Antibodies  >2 publications with HIF1AN and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >23 publications with HIF1AN and Vascular
 Blood Antibodies  >17 publications with HIF1AN and Blood
 Kidney Antibodies  >17 publications with HIF1AN and Kidney
 Liver Antibodies  >7 publications with HIF1AN and Liver
 Lung Antibodies  >6 publications with HIF1AN and Lung
 Brain Antibodies  >5 publications with HIF1AN and Brain
 Lymph Node Antibodies  >3 publications with HIF1AN and Lymph Node
 Bone Antibodies  >3 publications with HIF1AN and Bone
 Lymph Antibodies  >3 publications with HIF1AN and Lymph
 Heart Antibodies  >3 publications with HIF1AN and Heart
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