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CCL1 recombinant protein :: I-309 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS650555 CCL1 recombinant protein
Unit / Price
0.002 mg  /  $315 +1 FREE 8GB USB
0.01 mg  /  $455 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

I-309 (CCL1), Recombinant Protein

 Also Known As   

I-309, Recombinant, Human

 Product Gene Name   

CCL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Se r-Met-Gln.
 Chromosome Location    Chromosome: 17; NC_000017.10 (32687399..32690252, complement). Location: 17q12
 3D Structure    ModBase 3D Structure for Q76BR7
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 Host    E Coli
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 Purity/Purification    Highly Purified
98% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.
 Form/Format    Supplied as a lyophilized powder. No additives.
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 Biological Activity    Human I-309 is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract human T cells at 10.0-100.0ng/ml.
 Dimers and Aggregates    1% as determined by silver-stained SDS-PAGE gel analysis.
 Endotoxin Level    0.1ng/ug (IEU/ug) of Human HCC-1.
 Protein Content    Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280nm.
2. Analysis by RP-HPLC, using a calibrated solution of Human I-309 as a Reference Standard.
 Reconstitution    Reconstitute the lyophilized Human I-309 in sterile 18MO-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of CCL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CCL1 recombinant protein

   The human cytokine I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to a number of inflammatory cytokines. Recombinant Human I-309 is a single,non-glycosylated, polypeptide chain containing 74 amino acids and having a molecular mass of 8.504kD.
 Product Categories/Family for CCL1 recombinant protein    Growth Factors, Cytokines; Growth Factors-I-309
NCBI/Uniprot data below describe general gene information for CCL1. It may not necessarily be applicable to this product.
 NCBI GI #    37360916
 NCBI GeneID    6346
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 UniProt Primary Accession #    Q76BR7 [Other Products]
 UniProt Related Accession #    P22362; Q76BR7 [Other Products]
 Molecular Weight    3,266 Da [Similar Products]
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 NCBI Official Full Name    I-309
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 1
 NCBI Official Symbol    CCL1 [Similar Products]
 NCBI Official Synonym Symbols   
P500; SISe; TCA3; I-309; SCYA1
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 1; OTTHUMP00000163800; inflammatory cytokine I-309; small-inducible cytokine A1; T lymphocyte-secreted protein I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3)
 UniProt Protein Name    I-309
 Protein Family    Cyclin
 UniProt Gene Name    SCYA1 [Similar Products]
 UniProt Entry Name    Q76BR7_HUMAN
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 NCBI Summary for CCL1    This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8. [provided by RefSeq]
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 UniProt Comments for CCL1    CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Chemokine

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; signal transduction; chemotaxis
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 Research Articles on CCL1    1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCL1 recombinant proteinPathways associated with CCL1 recombinant protein
 Reference Product  PubMed Publications
 CCR8 recombinant protein  >81 publications with CCL1 and CCR8
 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with CCL1 recombinant proteinOrgans/Tissues associated with CCL1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >44 publications with CCL1 and Inflammation
 Skin Diseases Antibodies  >19 publications with CCL1 and Skin Diseases
 Nervous System Diseases Antibodies  >17 publications with CCL1 and Nervous System Diseases
 Neoplasms Antibodies  >16 publications with CCL1 and Neoplasms
 Asthma Antibodies  >15 publications with CCL1 and Asthma
 Vascular Diseases Antibodies  >9 publications with CCL1 and Vascular Diseases
 Cardiovascular Diseases Antibodies  >8 publications with CCL1 and Cardiovascular Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >8 publications with CCL1 and Encephalomyelitis, Autoimmune, Experimental
 Leukemia Antibodies  >5 publications with CCL1 and Leukemia
 Breast Neoplasms Antibodies  >4 publications with CCL1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >18 publications with CCL1 and Lung
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