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I 309 recombinant protein :: I-309 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144966 I 309 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

I-309 (I 309), Recombinant Protein

 Also Known As   

Recombinant Human I-309 (CCL1) His Tag

 Product Synonym Names    I 309 Human, His; I-309 (CCL1) Human Recombinant, His Tag; Small inducible cytokine A1; CCL1; T lymphocyte-secreted protein I-309; chemokine (C-C motif) ligand 1; P500; SISe; TCA3; I-309; SCYA1; I 309 His
 Product Gene Name   

I 309 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MKSMQV PFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK
 OMIM    182281
 3D Structure    ModBase 3D Structure for P22362
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 Host    E Coli
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 Purity/Purification    Greater than 85.0% as determined by SDS-PAGE.
 Form/Format    The I-309 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 2mM DTT, 10% glycerol and 50mM NaCl.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of I 309 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for I 309 recombinant protein

   Description: I-309 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 94 amino acids (24-96 a.a.) and having a molecular mass of 10.8kDa. The I-309 is purified by proprietary chromatographic techniques.

Introduction: Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
 Product Categories/Family for I 309 recombinant protein    CHEMOKINES; Chemokines
NCBI/Uniprot data below describe general gene information for I 309. It may not necessarily be applicable to this product.
 NCBI GI #    4506833
 NCBI GeneID    6346
 NCBI Accession #    NP_002972.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002981.2 [Other Products]
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 UniProt Primary Accession #    P22362 [Other Products]
 UniProt Secondary Accession #    Q2M309; B2R5G9 [Other Products]
 UniProt Related Accession #    P22362 [Other Products]
 Molecular Weight    10,992 Da
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 NCBI Official Full Name    C-C motif chemokine 1
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 1
 NCBI Official Symbol    CCL1 [Similar Products]
 NCBI Official Synonym Symbols   
P500; SISe; TCA3; I-309; SCYA1
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 1; T lymphocyte-secreted protein I-309; inflammatory cytokine I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3)
 UniProt Protein Name    C-C motif chemokine 1
 UniProt Synonym Protein Names   
Small-inducible cytokine A1; T lymphocyte-secreted protein I-309
 UniProt Gene Name    CCL1 [Similar Products]
 UniProt Synonym Gene Names    SCYA1 [Similar Products]
 UniProt Entry Name    CCL1_HUMAN
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 NCBI Summary for I 309    This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
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 UniProt Comments for I 309    CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: chemokine activity

Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; chemotaxis; signal transduction
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 Research Articles on I 309    1. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with I 309 recombinant proteinPathways associated with I 309 recombinant protein
 Reference Product  PubMed Publications
 CCR8 recombinant protein  >101 publications with I 309 and CCR8
 CCR5 recombinant protein  >23 publications with I 309 and CCR5
 CXCR3 recombinant protein  >13 publications with I 309 and CXCR3
 CCR1 recombinant protein  >13 publications with I 309 and CCR1
 CCR3 recombinant protein  >12 publications with I 309 and CCR3
 CCR2 recombinant protein  >9 publications with I 309 and CCR2
 CCR7 recombinant protein  >7 publications with I 309 and CCR7
 CX3CR1 recombinant protein  >6 publications with I 309 and CX3CR1
 CCR6 recombinant protein  >6 publications with I 309 and CCR6
 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with I 309 recombinant proteinOrgans/Tissues associated with I 309 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >74 publications with I 309 and Inflammation
 Immune System Diseases Antibodies  >74 publications with I 309 and Immune System Diseases
 Necrosis Antibodies  >36 publications with I 309 and Necrosis
 Lung Diseases Antibodies  >22 publications with I 309 and Lung Diseases
 Nervous System Diseases Antibodies  >22 publications with I 309 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >10 publications with I 309 and Cardiovascular Diseases
 Liver Diseases Antibodies  >6 publications with I 309 and Liver Diseases
 Kidney Diseases Antibodies  >6 publications with I 309 and Kidney Diseases
 Atherosclerosis Antibodies  >5 publications with I 309 and Atherosclerosis
 Carcinoma Antibodies  >4 publications with I 309 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >26 publications with I 309 and Lung
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