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I TAC recombinant protein :: I-TAC Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142041 I TAC recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

I-TAC (I TAC), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human I-TAC (CXCL11)

 Product Synonym Names    I TAC Human; I-TAC Human Recombinant (CXCL11); Small inducible cytokine B11; CXCL11; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Interferon-gamma-inducible protein 9; IP-9; H174; Beta-R1; chemokine (C-X-C motif) ligand 11; IP9; b-R1; SCYB11; SCYB9B; MGC102770
 Product Gene Name   

I TAC recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF
 OMIM    604852
 3D Structure    ModBase 3D Structure for O14625
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 Host    E Coli
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 Purity/Purification    Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    Lyophilized from a 0.2?m filtered concentrated (0.5mg/ml) solution in 20mM PB, pH 7.4, 100mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized I-TAC in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    Determined by its ability to chemoattract human IL-2 activated T-Lymphocytes using a concentration range of 0.1-10.0 ng/ml.
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 Preparation and Storage    Lyophilized I-TAC although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution I-TAC should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of I TAC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for I TAC recombinant protein

   Description: I-TAC Human Recombinant (Interferon-inducible T-cell alpha chemoattractant) produced in E Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 8300 Dalton. The I-TAC is purified by proprietary chromatographic techniques.

Introduction: Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokinen family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). I-TAC is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells. The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.
 Product Categories/Family for I TAC recombinant protein    CHEMOKINES; Chemokines; I-TAC (CXCL11)
NCBI/Uniprot data below describe general gene information for I TAC. It may not necessarily be applicable to this product.
 NCBI GI #    693074655
 NCBI GeneID    6373
 NCBI Accession #    NP_001289052.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001302123.1 [Other Products]
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 UniProt Primary Accession #    O14625 [Other Products]
 UniProt Secondary Accession #    Q53YA3; Q92840 [Other Products]
 UniProt Related Accession #    O14625 [Other Products]
 Molecular Weight    10,365 Da
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 NCBI Official Full Name    C-X-C motif chemokine 11 isoform 2
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 11
 NCBI Official Symbol    CXCL11 [Similar Products]
 NCBI Official Synonym Symbols   
IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 11; beta-R1; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; small-inducible cytokine B11
 UniProt Protein Name    C-X-C motif chemokine 11
 UniProt Synonym Protein Names   
Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11
 UniProt Gene Name    CXCL11 [Similar Products]
 UniProt Synonym Gene Names    ITAC; SCYB11; SCYB9B; IP-9; I-TAC [Similar Products]
 UniProt Entry Name    CXL11_HUMAN
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 NCBI Summary for I TAC    Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
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 UniProt Comments for I TAC    CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 4q21.2

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP metabolic process; signal transduction; inflammatory response; chemotaxis; regulation of cell proliferation
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 Research Articles on I TAC    1. Although TARC and I-TAC may not directly regulate pruritus in atopic dermatitis patients, these chemokines are very sensitive disease markers of AD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with I TAC recombinant proteinPathways associated with I TAC recombinant protein
 Reference Product  PubMed Publications
 CXCL10 recombinant protein  >461 publications with I TAC and CXCL10
 CXCL9 recombinant protein  >363 publications with I TAC and CXCL9
 CXCR3 recombinant protein  >308 publications with I TAC and CXCR3
 CCL5 recombinant protein  >87 publications with I TAC and CCL5
 CXCR7 recombinant protein  >40 publications with I TAC and CXCR7
 CCR5 recombinant protein  >38 publications with I TAC and CCR5
 CXCL13 recombinant protein  >14 publications with I TAC and CXCL13
 CXCL6 recombinant protein  >10 publications with I TAC and CXCL6
 CCR3 recombinant protein  >10 publications with I TAC and CCR3
 PF4 recombinant protein  >6 publications with I TAC and PF4
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
Diseases associated with I TAC recombinant proteinOrgans/Tissues associated with I TAC recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >187 publications with I TAC and Inflammation
 Necrosis Antibodies  >81 publications with I TAC and Necrosis
 Lung Diseases Antibodies  >61 publications with I TAC and Lung Diseases
 Disease Models, Animal Antibodies  >56 publications with I TAC and Disease Models, Animal
 Liver Diseases Antibodies  >35 publications with I TAC and Liver Diseases
 Cardiovascular Diseases Antibodies  >30 publications with I TAC and Cardiovascular Diseases
 Fibrosis Antibodies  >28 publications with I TAC and Fibrosis
 Death Antibodies  >23 publications with I TAC and Death
 Kidney Diseases Antibodies  >22 publications with I TAC and Kidney Diseases
 Adenocarcinoma Antibodies  >19 publications with I TAC and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >83 publications with I TAC and Lung
 Vascular Antibodies  >77 publications with I TAC and Vascular
 Skin Antibodies  >52 publications with I TAC and Skin
 Liver Antibodies  >44 publications with I TAC and Liver
 Muscle Antibodies  >30 publications with I TAC and Muscle
 Intestine Antibodies  >27 publications with I TAC and Intestine
 Bone Marrow Antibodies  >23 publications with I TAC and Bone Marrow
 Mouth Antibodies  >13 publications with I TAC and Mouth
 Uterus Antibodies  >9 publications with I TAC and Uterus
 Connective Tissue Antibodies  >4 publications with I TAC and Connective Tissue
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