NP_002494.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (NFKBIB), transcript variant 1, mRNA
NCBI Official Synonym Full Names
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NCBI Official Synonym Symbols
NCBI Protein Information
NF-kappa-B inhibitor beta; ikB-B; TRIP-9; ikB-beta; ikappaBbeta; NF-kappa-BIB; I-kappa-B-beta; TR-interacting protein 9; thyroid receptor-interacting protein 9
UniProt Protein Name
NF-kappa-B inhibitor beta
UniProt Synonym Protein Names
I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; Thyroid receptor-interacting protein 9
UniProt Synonym Gene Names
IKBB; TRIP9; NF-kappa-BIB; IkB-B; IkB-beta; IkappaBbeta; TR-interacting protein 9; TRIP-9 [Similar Products]
UniProt Entry Name
IKBB_HUMAN
NCBI Summary for I kappaB beta
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
UniProt Comments for I kappaB beta
Function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Subunit structure: Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2. Ref.8 Ref.11 Ref.12 Ref.13
Subcellular location: Cytoplasm
By similarity. Nucleus
By similarity.
Tissue specificity: Expressed in all tissues examined.
Post-translational modification: Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. Ref.9 Ref.10
Sequence similarities: Belongs to the NF-kappa-B inhibitor family.Contains 6 ANK repeats.
Product References and Citations for I kappaB beta recombinant protein
1.Fenwick, C. et al: A subclass of Ras proteins that regulate the degradation of I-kappa-B. Science 287: 869-873, 2000. 2.Hoffmann, A. et al: The I-kappa-B-NF-kappa-B signaling module: temporal control and selective gene activation. Science 298: 1241-1245, 2002.
Research Articles on I kappaB beta
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Products associated with I kappaB beta recombinant protein
Pathways associated with I kappaB beta recombinant protein
Diseases associated with I kappaB beta recombinant protein
Organs/Tissues associated with I kappaB beta recombinant protein
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