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IDO1 recombinant protein :: IDO Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS637936 IDO1 recombinant protein
Unit / Price
0.05 mg  /  $650 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IDO (IDO1), Recombinant Protein

★Popular Item★
 Also Known As   

IDO, Recombinant, Mouse (His) (Indoleamine 2,3-dioxygenase, INDO)

 Product Gene Name   

IDO1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Mouse IDO (aa 1-407) is fused at the C-terminus to a His-tag.
 Chromosome Location    Chromosome: 8; NC_000008.10 (39771328..39786309). Location: 8p12-p11
 OMIM    147435
 3D Structure    ModBase 3D Structure for P14902
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 Host    E.Coli
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 Purity/Purification    Highly Purified
>=90% (SDS-PAGE)
 Form/Format    0.2um-filtered solution in 50mM TRIS-Cl, pH 7.4, 1mM EDTA.
 Concentration    1mg/ml (lot specific)
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 Biological Activity    Specific Activity: >100,000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.
 Endotoxin    <1EU/ug (LAL)
 Heme Content    Not determined for end product. 7uM hermin was adde for protein induction.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months after receipt at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of IDO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IDO1 recombinant protein

   IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.

Recombinant protein corresponding to mouse IDO (aa1-407), at C-terminus fused to His-tag.
 Product Categories/Family for IDO1 recombinant protein    Molecular Biology; MB-Enzymes, Oxidase
NCBI/Uniprot data below describe general gene information for IDO1. It may not necessarily be applicable to this product.
 NCBI GI #    4504577
 NCBI GeneID    3620
 NCBI Accession #    NP_002155.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002164.5 [Other Products]
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 UniProt Primary Accession #    P14902 [Other Products]
 UniProt Secondary Accession #    Q540B4 [Other Products]
 UniProt Related Accession #    P14902 [Other Products]
 Molecular Weight    ~40kD (SDS-PAGE) [Similar Products]
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 NCBI Official Full Name    indoleamine 2,3-dioxygenase 1
 NCBI Official Synonym Full Names    indoleamine 2,3-dioxygenase 1
 NCBI Official Symbol    IDO1 [Similar Products]
 NCBI Official Synonym Symbols   
IDO; INDO; IDO-1
[Similar Products]
 NCBI Protein Information    indoleamine 2,3-dioxygenase 1; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
 UniProt Protein Name    Indoleamine 2,3-dioxygenase 1
 UniProt Synonym Protein Names   
Indoleamine-pyrrole 2,3-dioxygenase
 Protein Family    Indoleamine 2,3-dioxygenase
 UniProt Gene Name    IDO1 [Similar Products]
 UniProt Synonym Gene Names    IDO; INDO; IDO-1 [Similar Products]
 UniProt Entry Name    I23O1_HUMAN
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 NCBI Summary for IDO1    This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
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 UniProt Comments for IDO1    INDO: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family.

Protein type: Amino Acid Metabolism - tryptophan; Cell cycle regulation; Oxidoreductase; EC 1.13.11.52

Chromosomal Location of Human Ortholog: 8p12-p11

Cellular Component: smooth muscle contractile fiber; stereocilium bundle; cytosol

Molecular Function: electron carrier activity; metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activity

Biological Process: regulation of activated T cell proliferation; positive regulation of T-helper 2 type immune response; positive regulation of chronic inflammatory response; negative regulation of interleukin-10 production; positive regulation of interleukin-12 production; tryptophan catabolic process to kynurenine; response to lipopolysaccharide; female pregnancy; negative regulation of T cell proliferation; cytokine production during acute inflammatory response; tryptophan catabolic process; multicellular organismal response to stress; positive regulation of T cell tolerance induction
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 Research Articles on IDO1    1. In human colon cancer cells, blockade of IDO1 activity reduced nuclear and activated b-catenin, transcription of its target genes (cyclin D1 and Axin2), and, ultimately, proliferation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IDO1 recombinant proteinPathways associated with IDO1 recombinant protein
 Reference Product  PubMed Publications
 TDO2 recombinant protein  >4 publications with IDO1 and TDO2
 IFNG recombinant protein  >3 publications with IDO1 and IFNG
 KYNU recombinant protein  >2 publications with IDO1 and KYNU
 CTLA4 recombinant protein  >1 publications with IDO1 and CTLA4
 TPH1 recombinant protein  >1 publications with IDO1 and TPH1
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tryptophan Catabolism Pathway antibodies  Tryptophan Catabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway antibodies  Tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway Diagram
Diseases associated with IDO1 recombinant proteinOrgans/Tissues associated with IDO1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >26 publications with IDO1 and Inflammation
 Neoplasms Antibodies  >19 publications with IDO1 and Neoplasms
 Neoplasms, Experimental Antibodies  >6 publications with IDO1 and Neoplasms, Experimental
 Colitis Antibodies  >5 publications with IDO1 and Colitis
 Breast Neoplasms Antibodies  >4 publications with IDO1 and Breast Neoplasms
 Necrosis Antibodies  >4 publications with IDO1 and Necrosis
 Lung Diseases Antibodies  >4 publications with IDO1 and Lung Diseases
 Neurodegenerative Diseases Antibodies  >4 publications with IDO1 and Neurodegenerative Diseases
 Weight Loss Antibodies  >2 publications with IDO1 and Weight Loss
 Endometriosis Antibodies  >2 publications with IDO1 and Endometriosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with IDO1 and Brain
 Bone Antibodies  >9 publications with IDO1 and Bone
 Lung Antibodies  >7 publications with IDO1 and Lung
 Intestine Antibodies  >4 publications with IDO1 and Intestine
 Placenta Antibodies  >4 publications with IDO1 and Placenta
 Liver Antibodies  >3 publications with IDO1 and Liver
 Kidney Antibodies  >3 publications with IDO1 and Kidney
 Embryonic Tissue Antibodies  >3 publications with IDO1 and Embryonic Tissue
 Uterus Antibodies  >3 publications with IDO1 and Uterus
 Eye Antibodies  >2 publications with IDO1 and Eye
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