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IFNB1 recombinant protein :: IFN BETA 1B Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS232060 IFNB1 recombinant protein
Unit / Price
0.01 mg  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFN BETA 1B (IFNB1), Recombinant Protein

 Also Known As   

RECOMBINANT HUMAN INTERFERON BETA 1B

 Product Gene Name   

IFNB1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147640
 3D Structure    ModBase 3D Structure for P01574
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 Purity/Purification    >98% by SDS PAGE and HPLC analysis.
 Form/Format    Purified Recombinant protein - lyophilised.
 Concentration    Approximate Protein Concentration: 0.1 mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.1ml distilled water.Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Buffer Solution    Lyophilised from a solution containing human albumin and dextrose.
 Activity    The Specific activity determined using a viral resistance assay is of 32 x 106 IU/mg. The viral resistance assays used are the human WISH cell line and VSV, or the monkey VERO cell line and EMCV.
 Target Species    Human
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 Preparation and Storage    Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of IFNB1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IFNB1 recombinant protein

   Recombinant human interferon beta 1b produced in E Coli is a single non-glycosylated variant form of the human interferon beta-1b polypeptide chain. The interferon gene was cloned from human fibroblasts and altered to substitute Serine for the Cysteine at residue 17.
 Applications Tested/Suitable for IFNB1 recombinant protein   

Functional Assays (FN)

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NCBI/Uniprot data below describe general gene information for IFNB1. It may not necessarily be applicable to this product.
 NCBI GI #    4504603
 NCBI GeneID    3456
 NCBI Accession #    NP_002167.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002176.2 [Other Products]
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 UniProt Primary Accession #    P01574 [Other Products]
 UniProt Secondary Accession #    Q5VWC9 [Other Products]
 UniProt Related Accession #    P01574 [Other Products]
 Molecular Weight    18.5 kDa (165 amino acid residues) [Similar Products]
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 NCBI Official Full Name    interferon beta
 NCBI Official Synonym Full Names    interferon, beta 1, fibroblast
 NCBI Official Symbol    IFNB1 [Similar Products]
 NCBI Official Synonym Symbols   
IFB; IFF; IFNB
[Similar Products]
 NCBI Protein Information    interferon beta; IFN-beta; fibroblast interferon
 UniProt Protein Name    Interferon beta
 UniProt Synonym Protein Names   
Fibroblast interferon
 Protein Family    Interferon
 UniProt Gene Name    IFNB1 [Similar Products]
 UniProt Synonym Gene Names    IFB; IFNB; IFN-beta [Similar Products]
 UniProt Entry Name    IFNB_HUMAN
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 UniProt Comments for IFNB1    IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: extracellular space; extracellular region

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; response to virus; cytokine and chemokine mediated signaling pathway; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; cell surface receptor linked signal transduction; response to exogenous dsRNA; negative regulation of viral genome replication; B cell differentiation; defense response to bacterium; positive regulation of innate immune response; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; positive regulation of peptidyl-serine phosphorylation of STAT protein; B cell activation during immune response
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 Research Articles on IFNB1    1. A20 has a novel atheroprotective function in vascular cells through modulation of IFNgamma/STAT1 signaling in an IFNbeta-dependent, but NF-kappaB-independent, manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IFNB1 recombinant proteinPathways associated with IFNB1 recombinant protein
 Reference Product  PubMed Publications
 IRF3 recombinant protein  >18 publications with IFNB1 and IRF3
 IFNAR1 recombinant protein  >6 publications with IFNB1 and IFNAR1
 IRF7 recombinant protein  >4 publications with IFNB1 and IRF7
 STAT2 recombinant protein  >3 publications with IFNB1 and STAT2
 EP300 recombinant protein  >1 publications with IFNB1 and EP300
 CREBBP recombinant protein  >1 publications with IFNB1 and CREBBP
 IRF1 recombinant protein  >1 publications with IFNB1 and IRF1
 IFNAR2 recombinant protein  >1 publications with IFNB1 and IFNAR2
 Products by Pathway  Pathway Diagram
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 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
Diseases associated with IFNB1 recombinant protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >9 publications with IFNB1 and Immune System Diseases
 Inflammation Antibodies  >8 publications with IFNB1 and Inflammation
 Necrosis Antibodies  >7 publications with IFNB1 and Necrosis
 Carcinoma Antibodies  >4 publications with IFNB1 and Carcinoma
 Melanoma Antibodies  >3 publications with IFNB1 and Melanoma
 Leukemia Antibodies  >3 publications with IFNB1 and Leukemia
 Lung Neoplasms Antibodies  >3 publications with IFNB1 and Lung Neoplasms
 Heart Diseases Antibodies  >2 publications with IFNB1 and Heart Diseases
 Multiple Sclerosis Antibodies  >2 publications with IFNB1 and Multiple Sclerosis
 Pancreatic Neoplasms Antibodies  >2 publications with IFNB1 and Pancreatic Neoplasms
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