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IFN-lambda1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS696050 IFN-lambda1 recombinant protein
Unit / Price
0.005 mg  /  $125 +1 FREE 8GB USB
0.02 mg  /  $195 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
0.5 mg  /  $1,410 +1 FREE 8GB USB
1 mg  /  $2,320 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFN-lambda1, Recombinant Protein

★Popular Item★
 Also Known As   

Human IFN-lambda1

 Product Synonym Names    Recombinant Human IFN-lambda1
 Product Gene Name   

IFN-lambda1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    PTSKPTTTG KGCHIGRFK SLSPQELAS FKKARDALE ESLKLKNWS CSSPVFPGN WDLRLLQVR ERPVALEAE LALTLKVLE AAAGPALED VLDQPLHTL HHILSQLQA CIQPQPTAG PRPRGRLHH WLHRLQEAP KKESAGCLE ASVTFNLFR LLTRDLKYV ADGNLCLRT STHPEST
 OMIM    607403
 3D Structure    ModBase 3D Structure for Q8IU54
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 Host    E Coli
 Species Reactivity    Species Reactivity: Human
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 Purity/Purification    Above 98% as determined by SDS-PAGE Analysis.
 Form/Format    Sterile filtered through a 0.2 micron filter. Lyophilized from 10mM Sodium Phoshpate, pH7.5
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 Species    Human
 Biological Activity    Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.
 Authenticity    Verified by N-terminal and Mass Spectrometry analyses (when applicable).
 Endotoxin level    <0.1 ng/ug of protein (<1EU/ug)
 Protein Content    Verified by UV Spectroscopy and/or SDS-PAGE gel
 Reconstitution    Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20C to -80C
    
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 Preparation and Storage    Store at -20C
 Other Notes    Small volumes of IFN-lambda1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IFN-lambda1 recombinant protein

   IFN lambda-1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77). Recombinant human IFN-lambda 1 is a 19.8 kDa protein containing 178 amino acid residues.
NCBI/Uniprot data below describe general gene information for IFN-lambda1. It may not necessarily be applicable to this product.
 NCBI GI #    55976527
 NCBI GeneID    282618
 NCBI Accession #    Q8IU54.1 [Other Products]
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 UniProt Primary Accession #    Q8IU54 [Other Products]
 UniProt Secondary Accession #    Q17R34; A0AV25 [Other Products]
 UniProt Related Accession #    Q8IU54 [Other Products]
 Molecular Weight    21,898 Da
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 NCBI Official Full Name    Interferon lambda-1
 NCBI Official Synonym Full Names    interferon, lambda 1
 NCBI Official Symbol    IFNL1 [Similar Products]
 NCBI Official Synonym Symbols   
IL29; IL-29
[Similar Products]
 NCBI Protein Information    interferon lambda-1; IFN-lambda-1; interleukin-29; cytokine Zcyto21; interferon-lambda-1; interleukin 29 (interferon, lambda 1)
 UniProt Protein Name    Interferon lambda-1
 UniProt Synonym Protein Names   
Cytokine Zcyto21; Interleukin-29; IL-29
 UniProt Gene Name    IFNL1 [Similar Products]
 UniProt Synonym Gene Names    IL29; ZCYTO21; IFN-lambda-1; IL-29 [Similar Products]
 UniProt Entry Name    IFNL1_HUMAN
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 NCBI Summary for IFN-lambda1    This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFN-lambda1    IL29: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Secreted, signal peptide; Cytokine; Cell cycle regulation; Secreted

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: extracellular space; extracellular region; interleukin-28 receptor complex

Molecular Function: cytokine activity; interleukin-28 receptor binding; receptor binding

Biological Process: positive regulation of immune response; positive regulation of transcription, DNA-dependent; positive regulation of JAK-STAT cascade; JAK-STAT cascade; negative regulation of T cell differentiation; negative regulation of cell proliferation; negative regulation of interleukin-13 production; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of T-helper 2 type immune response; negative regulation of interleukin-5 production; positive regulation of MHC class I biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of memory T cell differentiation; defense response to virus
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 Research Articles on IFN-lambda1    1. our data suggest that human but not mouse hepatocytes are responsive to IFN-lambda in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IFN-lambda1 recombinant proteinPathways associated with IFN-lambda1 recombinant protein
 Reference Product  PubMed Publications
 TLR3 recombinant protein  >2 publications with IFN-lambda1 and TLR3
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Type III Interferon Signaling Pathway antibodies  Type III Interferon Signaling Pathway Diagram
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