Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow IGF-1 LR3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • ATGL Antibody
 • Thyroglobulin (TG) ELISA Kit
 • NFRKB Antibody
 • CD16 Antibody
 • Mer Antibody
 • TNFS15-VEGI (Vascular Endothelial Growth Inhibitor) Antibody
 • RPTOR Antibody
 • 5'-AMP-activated protein kinase subunit beta-2 (Prkab2) Recombinant Protein
 • Amyloid Beta 40 (Abeta40) ELISA Kit
 • WNT2B Antibody
 • Cytokeratin 10 (KRT10) Antibody
 • Cyclophilin B (CYPB) Recombinant Protein
 • Acetylcholine (ACH) ELISA Kit
 • Interleukin 4 (IL4) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

IGF-1 LR3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS692296 IGF-1 LR3 recombinant protein
Unit / Price
0.2 mg  /  $215 +1 FREE 8GB USB
1 mg  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF-1 LR3, Recombinant Protein

★Popular Item★
 Also Known As   

Human IGF-1 LR3

 Product Synonym Names    Long R3 IGF-I; Insulin-like Growth Factor-I; Somatamedin C; IGF-IA
 Product Gene Name   

IGF-1 LR3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGS SSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
 OMIM    X00173 mRNA
 3D Structure    ModBase 3D Structure for P05019
Section Bar
 Host    E Coli
 Species Reactivity    Human
Section Bar
 Purity/Purification    > 98% by SDS-PAGE & HPLC analyses
 Form/Format    Lyophilized
Section Bar
 Biological Activity    The ED50 was determined by a cell proliferation assay using FDC-P1 cells is <= 2.0 ng/ml, corresponding to a specific activity of >= 5 x 105 units/mg.
Section Bar
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of IGF-1 LR3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for IGF-1 LR3 recombinant protein

   The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. IGF-I LR3 is a recombinant analog of human IGF-I comprised of the complete IGF-I sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension. Specifically engineered for higher biological potency in vitro, IGF-I LR3 has an increased half-life and a binding aversion to native proteins within the body that make it ideal for both research and large-scale culturing. Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues.
 Product Categories/Family for IGF-1 LR3 recombinant protein    Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for IGF-1 LR3. It may not necessarily be applicable to this product.
 NCBI GI #    124263
 NCBI GeneID    3479
 NCBI Accession #    P05019.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P05019 [Other Products]
 UniProt Secondary Accession #    P01343; Q14620; B2RWM7; E9PD02 [Other Products]
 UniProt Related Accession #    P05019 [Other Products]
 Molecular Weight    17,762 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Insulin-like growth factor I
 NCBI Official Synonym Full Names    insulin like growth factor 1
 NCBI Official Symbol    IGF1 [Similar Products]
 NCBI Official Synonym Symbols   
MGF; IGFI; IGF-I
[Similar Products]
 NCBI Protein Information    insulin-like growth factor I
 UniProt Protein Name    Insulin-like growth factor I
 UniProt Synonym Protein Names   
Mechano growth factor; MGF; Somatomedin-C
 UniProt Gene Name    IGF1 [Similar Products]
 UniProt Synonym Gene Names    IBP1; IGF-I; MGF [Similar Products]
Section Bar
 NCBI Summary for IGF-1 LR3    The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Section Bar
 UniProt Comments for IGF-1 LR3    IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: extracellular region; extracellular space; insulin-like growth factor binding protein complex; plasma membrane

Molecular Function: hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding

Biological Process: activation of MAPK activity; activation of protein kinase B; cell activation; cell motility; cell proliferation; cellular protein metabolic process; DNA replication; glycolate metabolic process; insulin-like growth factor receptor signaling pathway; muscle development; muscle hypertrophy; myoblast differentiation; myoblast proliferation; myotube cell development; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; platelet degranulation; positive regulation of activated T cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of glycolysis; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPKKK cascade; positive regulation of mitosis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein import into nucleus, translocation; positive regulation of protein secretion; positive regulation of Ras protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; protein kinase B signaling cascade; protein stabilization; proteoglycan biosynthetic process; Ras protein signal transduction; regulation of gene expression; regulation of multicellular organism growth; response to heat; satellite cell compartment self-renewal involved in skeletal muscle regeneration; signal transduction; skeletal development

Disease: Insulin-like Growth Factor I Deficiency
Table BarTOPTable Bar
 Research Articles on IGF-1 LR3    1. MEF2D regulates IGF-1-induced proliferation and apoptosis in CM development, indicating IGF-1-MEF2D pathway may be a useful target for treatment.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with IGF-1 LR3 recombinant proteinPathways associated with IGF-1 LR3 recombinant protein
 Reference Product  PubMed Publications
 IGF1R recombinant protein  >589 publications with IGF-1 LR3 and IGF1R
 IGFBP3 recombinant protein  >285 publications with IGF-1 LR3 and IGFBP3
 IGFBP1 recombinant protein  >89 publications with IGF-1 LR3 and IGFBP1
 IRS1 recombinant protein  >83 publications with IGF-1 LR3 and IRS1
 IGFBP2 recombinant protein  >67 publications with IGF-1 LR3 and IGFBP2
 INSR recombinant protein  >56 publications with IGF-1 LR3 and INSR
 TGFB1 recombinant protein  >43 publications with IGF-1 LR3 and TGFB1
 IGFBP5 recombinant protein  >35 publications with IGF-1 LR3 and IGFBP5
 INS recombinant protein  >32 publications with IGF-1 LR3 and INS
 IGFBP4 recombinant protein  >29 publications with IGF-1 LR3 and IGFBP4
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Breast Cancer Pathway antibodies  Breast Cancer Pathway Diagram
 Breast Cancer Pathway antibodies  Breast Cancer Pathway Diagram
 Cardiac Hypertrophic Response Pathway antibodies  Cardiac Hypertrophic Response Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
Diseases associated with IGF-1 LR3 recombinant proteinOrgans/Tissues associated with IGF-1 LR3 recombinant protein
 Disease Name  Pubmed Publications
 Acromegaly Antibodies  >163 publications with IGF-1 LR3 and Acromegaly
 Breast Neoplasms Antibodies  >146 publications with IGF-1 LR3 and Breast Neoplasms
 Inflammation Antibodies  >130 publications with IGF-1 LR3 and Inflammation
 Female Urogenital Diseases Antibodies  >120 publications with IGF-1 LR3 and Female Urogenital Diseases
 Adenoma Antibodies  >90 publications with IGF-1 LR3 and Adenoma
 Pituitary Neoplasms Antibodies  >67 publications with IGF-1 LR3 and Pituitary Neoplasms
 Necrosis Antibodies  >66 publications with IGF-1 LR3 and Necrosis
 Prostatic Neoplasms Antibodies  >58 publications with IGF-1 LR3 and Prostatic Neoplasms
 Kidney Diseases Antibodies  >48 publications with IGF-1 LR3 and Kidney Diseases
 Hypertension Antibodies  >48 publications with IGF-1 LR3 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >822 publications with IGF-1 LR3 and Blood
 Muscle Antibodies  >388 publications with IGF-1 LR3 and Muscle
 Bone Antibodies  >346 publications with IGF-1 LR3 and Bone
 Liver Antibodies  >336 publications with IGF-1 LR3 and Liver
 Brain Antibodies  >292 publications with IGF-1 LR3 and Brain
 Vascular Antibodies  >162 publications with IGF-1 LR3 and Vascular
 Connective Tissue Antibodies  >147 publications with IGF-1 LR3 and Connective Tissue
 Heart Antibodies  >146 publications with IGF-1 LR3 and Heart
 Ovary Antibodies  >138 publications with IGF-1 LR3 and Ovary
 Lung Antibodies  >119 publications with IGF-1 LR3 and Lung
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions