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IGF-1R recombinant protein

Scan QR to view Datasheet Catalog #    MBS306075 IGF-1R recombinant protein
Unit / Price
0.01 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF-1R, Recombinant Protein

 Also Known As   

Recombinant Human IGF-1R Protein

 Product Gene Name   

IGF-1R recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147370
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 Characterization    On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 43kDa.
 Source    Recombinant IGF-1R protein encoding aa 1213-1367 expressed in E Coli.
 Domain    aa 1213-1367
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 Preparation and Storage    Store at -20 degree to -80 degree C. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of IGF-1R recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IGF-1R. It may not necessarily be applicable to this product.
 NCBI GI #    4557665
 NCBI GeneID    3480
 NCBI Accession #    NP_000866.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000875 [Other Products]
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 UniProt Secondary Accession #    Q14CV2; Q9UCC0; B1B5Y2 [Other Products]
 UniProt Related Accession #    P08069 [Other Products]
 Molecular Weight    154,793 Da
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 NCBI Official Full Name    insulin-like growth factor 1 receptor isoform 1
 NCBI Official Synonym Full Names    insulin-like growth factor 1 receptor
 NCBI Official Symbol    IGF1R [Similar Products]
 NCBI Official Synonym Symbols   
IGFR; CD221; IGFIR; JTK13
[Similar Products]
 NCBI Protein Information    insulin-like growth factor 1 receptor; IGF-I receptor; insulin-like growth factor I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2
 UniProt Protein Name    Insulin-like growth factor 1 receptor
 UniProt Synonym Protein Names   
Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
 UniProt Gene Name    IGF1R [Similar Products]
 UniProt Synonym Gene Names    IGF-I receptor [Similar Products]
 UniProt Entry Name    IGF1R_HUMAN
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 NCBI Summary for IGF-1R    This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
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 UniProt Comments for IGF-1R    IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541.

Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; TK group; InsR family

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: neuron projection; intracellular membrane-bound organelle; membrane; integral to plasma membrane; plasma membrane; caveola; receptor complex

Molecular Function: insulin binding; identical protein binding; insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; insulin receptor substrate binding; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; G-protein alpha-subunit binding; ATP binding; insulin-like growth factor receptor activity; insulin receptor binding

Biological Process: epidermis development; phosphoinositide 3-kinase cascade; inactivation of MAPKK activity; protein heterooligomerization; protein amino acid autophosphorylation; exocrine pancreas development; signal transduction; regulation of JNK cascade; response to vitamin E; mammary gland development; positive regulation of MAPKKK cascade; male sex determination; positive regulation of cell proliferation; protein tetramerization; positive regulation of cytokinesis; phosphoinositide-mediated signaling; negative regulation of protein kinase B signaling cascade; positive regulation of mitosis; negative regulation of transcription factor activity; positive regulation of protein kinase B signaling cascade; axonogenesis; insulin-like growth factor receptor signaling pathway; establishment of cell polarity; insulin receptor signaling pathway; immune response; brain development; positive regulation of DNA replication; positive regulation of cell migration; negative regulation of apoptosis

Disease: Insulin-like Growth Factor I, Resistance To
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 Research Articles on IGF-1R    1. Increased expression of IGF1R is associated with oral squamous cell carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF-1R recombinant proteinPathways associated with IGF-1R recombinant protein
 Reference Product  PubMed Publications
 IGF1 recombinant protein  >440 publications with IGF-1R and IGF1
 IRS1 recombinant protein  >246 publications with IGF-1R and IRS1
 IGF2 recombinant protein  >181 publications with IGF-1R and IGF2
 IRS2 recombinant protein  >89 publications with IGF-1R and IRS2
 SHC1 recombinant protein  >34 publications with IGF-1R and SHC1
 GRB10 recombinant protein  >27 publications with IGF-1R and GRB10
 PTPN11 recombinant protein  >19 publications with IGF-1R and PTPN11
 ESR1 recombinant protein  >10 publications with IGF-1R and ESR1
 PIK3R1 recombinant protein  >7 publications with IGF-1R and PIK3R1
 UBC recombinant protein  >1 publications with IGF-1R and UBC
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with IGF-1R recombinant proteinOrgans/Tissues associated with IGF-1R recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >488 publications with IGF-1R and Breast Neoplasms
 Adenocarcinoma Antibodies  >340 publications with IGF-1R and Adenocarcinoma
 Disease Models, Animal Antibodies  >300 publications with IGF-1R and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >261 publications with IGF-1R and Neoplasms, Experimental
 Insulin-Like Growth Factor I, Resistance To Antibodies  >256 publications with IGF-1R and Insulin-Like Growth Factor I, Resistance To
 Cardiovascular Diseases Antibodies  >234 publications with IGF-1R and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >233 publications with IGF-1R and Lung Neoplasms
 Lung Diseases Antibodies  >198 publications with IGF-1R and Lung Diseases
 Growth Disorders Antibodies  >196 publications with IGF-1R and Growth Disorders
 Cell Transformation, Neoplastic Antibodies  >190 publications with IGF-1R and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >723 publications with IGF-1R and Blood
 Muscle Antibodies  >618 publications with IGF-1R and Muscle
 Vascular Antibodies  >420 publications with IGF-1R and Vascular
 Brain Antibodies  >410 publications with IGF-1R and Brain
 Liver Antibodies  >385 publications with IGF-1R and Liver
 Bone Antibodies  >374 publications with IGF-1R and Bone
 Lung Antibodies  >314 publications with IGF-1R and Lung
 Kidney Antibodies  >272 publications with IGF-1R and Kidney
 Prostate Antibodies  >235 publications with IGF-1R and Prostate
 Heart Antibodies  >209 publications with IGF-1R and Heart
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