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IGF1 recombinant protein :: IGF-I Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS400008 IGF1 recombinant protein
Unit / Price
0.01 mg  /  $155 +1 FREE 8GB USB
0.05 mg  /  $240 +1 FREE 8GB USB
0.1 mg  /  $330 +1 FREE 8GB USB
0.5 mg  /  $920 +1 FREE 8GB USB
1 mg  /  $1,585 +1 FREE 8GB USB
5 mg  /  $6,205 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF-I (IGF1), Recombinant Protein

★Popular Item★
 Also Known As   

Fish (denis) IGF-I

 Product Synonym Names    Fish gilthead seabream (Sparus aurata) IGF-I
 Product Gene Name   

IGF1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first ten N-terminal amino acids was determined and was found to be Met-Ser-Pr o-Glu-Thr- Leu-Cys-Gl y-Ala-Glu.
 OMIM    147440
 3D Structure    ModBase 3D Structure for P05019
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 Host    E Coli
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 Purity/Purification    Greater than 98.0% as determined by:
(a) Analysis by reducing and non-reducing SDS-PAGE gel.
(b) Gel-filtration chromatography under non denaturing conditions.
 Form/Format    White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized gsIGF-I in sterile 0.4% NaHCO3 adjusted, not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
 Protein Content    Protein quantization was carried out by UV spectroscopy at 280 nm using the absorbency value of 0.60 as the extinction coefficient for a 0.1% (1mg/ml) solution at pH 8.0. This value is calculated by the DNAman computer analysis program of protein sequences.
 Dimers and Aggregates    The purified gsIGF-I consists of > 97% monomers as determined by gel-filtration chromatography.
 Endotoxin    Less than 0.1 ng/ug (IEU/ug) of Gilthead Seabream IGF-I
 Formulation    The protein was lyophilized from a concentrated (1mg/ml) solution with 0.02% NaHCO3.
 Biological Activity    Binding assays of the 125I-gsIGF-I to gilthead seabream or carp (Cyprinus carpio) sera resulted in high specific binding, indicating the existence of one or more IGF-binding proteins. In binding experiments to crude gilthead seabream brain homogenate, using human (h) IGF-I as a ligand, the respective IC50 value of hIGF-I was about fourfold lower than that of gsIGF-I. Recombinant gsIGF-I exhibited mitogenic activity in a mouse mammary gland-derived MME-L1 cell line which was approximately 200-fold lower than that of hIGF-1. Binding experiments to intact MME-L1 cells suggests that this difference most likely results from a correspondingly lower affinity for IGF-I receptor in these cells. In contrast, the activities of gsIGF-I and hIGF-I measured by 35S uptake by gill arches from the goldfish (Carassius auratus) were identical, indicating that the recombinant gsIGF-I is biologically active.
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 Preparation and Storage    Lyophilized gsIGF-I although stable at room temperature for several weeks, should be stored desiccated below -18 degree C. Upon reconstitution at > 0.1 gsIGF-I mg/ml and up to 2 2 mg/ml and filter sterilization gsIGF-I can be stored at +4 degree C
 Other Notes    Small volumes of IGF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IGF1 recombinant protein

   Gilthead seabream (Sparus aurata) insulin-like growth factor-I (gsIGF-I) cDNA coding the mature protein was expressed in Escherichia coli. The expressed protein contained within the inclusion-body pellet was solubilized and purified to over 98% purity, as a monomeric methionyl-gsIGF-I. Amino acid composition and N-terminal sequence confirmed the identity to be the predicted protein. For reference see Fine et al., J Endocrinol. 1997 53:139-150.
 Product Categories/Family for IGF1 recombinant protein    Growth hormone and prolactin family; Hormones, Cytokines and Growth Factors
NCBI/Uniprot data below describe general gene information for IGF1. It may not necessarily be applicable to this product.
 NCBI GI #    184834
 NCBI GeneID    3479
 NCBI Accession #    AAA52789.1 [Other Products]
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 UniProt Primary Accession #    P05019 [Other Products]
 UniProt Secondary Accession #    P01343; Q14620; B2RWM7; E9PD02 [Other Products]
 UniProt Related Accession #    P05019 [Other Products]
 Molecular Weight    17,762 Da [Similar Products]
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 NCBI Official Full Name    insulin-like growth factor I
 NCBI Official Synonym Full Names    insulin-like growth factor 1 (somatomedin C)
 NCBI Official Symbol    IGF1 [Similar Products]
 NCBI Official Synonym Symbols   
IGFI; IGF-I; IGF1A
[Similar Products]
 NCBI Protein Information    insulin-like growth factor I; IGF-IA; IGF-IB; MGF; insulin-like growth factor IA; insulin-like growth factor IB; mechano growth factor; somatomedin-C
 UniProt Protein Name    Insulin-like growth factor I
 UniProt Synonym Protein Names   
Mechano growth factor; MGF; Somatomedin-C
 Protein Family    Insulin-like growth factor
 UniProt Gene Name    IGF1 [Similar Products]
 UniProt Synonym Gene Names    IBP1; IGF-I; MGF [Similar Products]
 UniProt Entry Name    IGF1_HUMAN
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 NCBI Summary for IGF1    The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
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 UniProt Comments for IGF1    IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: insulin-like growth factor binding protein complex; extracellular space; plasma membrane; extracellular region

Molecular Function: integrin binding; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; insulin receptor binding

Biological Process: muscle development; positive regulation of transcription, DNA-dependent; chondroitin sulfate proteoglycan biosynthetic process; glycolate metabolic process; exocrine pancreas development; water homeostasis; positive regulation of glucose import; positive regulation of fibroblast proliferation; proteoglycan biosynthetic process; inner ear development; positive regulation of DNA binding; muscle hypertrophy; platelet activation; positive regulation of mitosis; positive regulation of protein import into nucleus, translocation; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; branching morphogenesis of a tube; regulation of gene expression; response to heat; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of insulin-like growth factor receptor signaling pathway; myoblast proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of glycogen biosynthetic process; signal transduction; positive regulation of smooth muscle cell migration; positive regulation of activated T cell proliferation; negative regulation of cell proliferation; glial cell differentiation; platelet degranulation; mammary gland development; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; DNA replication; skeletal development; positive regulation of granule cell precursor proliferation; phosphoinositide-mediated signaling; multicellular organism growth; myotube cell development; regulation of multicellular organism growth; satellite cell compartment self-renewal involved in skeletal muscle regeneration; myoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of protein kinase B signaling cascade; cell proliferation; cellular protein metabolic process; positive regulation of tyrosine phosphorylation of Stat5 protein; Ras protein signal transduction; positive regulation of glycolysis; blood vessel remodeling; positive regulation of Ras protein signal transduction; blood coagulation; cell motility; positive regulation of DNA replication

Disease: Insulin-like Growth Factor I Deficiency
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 Research Articles on IGF1    1. The combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels, were assessed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF1 recombinant proteinPathways associated with IGF1 recombinant protein
 Reference Product  PubMed Publications
 IGF1R recombinant protein  >461 publications with IGF1 and IGF1R
 IGFBP3 recombinant protein  >234 publications with IGF1 and IGFBP3
 IGFBP1 recombinant protein  >79 publications with IGF1 and IGFBP1
 IRS1 recombinant protein  >71 publications with IGF1 and IRS1
 IGFBP2 recombinant protein  >65 publications with IGF1 and IGFBP2
 INSR recombinant protein  >43 publications with IGF1 and INSR
 TGFB1 recombinant protein  >31 publications with IGF1 and TGFB1
 IGFBP5 recombinant protein  >30 publications with IGF1 and IGFBP5
 INS recombinant protein  >28 publications with IGF1 and INS
 IGFBP4 recombinant protein  >25 publications with IGF1 and IGFBP4
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with IGF1 recombinant proteinOrgans/Tissues associated with IGF1 recombinant protein
 Disease Name  Pubmed Publications
 Acromegaly Antibodies  >136 publications with IGF1 and Acromegaly
 Breast Neoplasms Antibodies  >115 publications with IGF1 and Breast Neoplasms
 Inflammation Antibodies  >92 publications with IGF1 and Inflammation
 Female Urogenital Diseases Antibodies  >88 publications with IGF1 and Female Urogenital Diseases
 Adenoma Antibodies  >66 publications with IGF1 and Adenoma
 Prostatic Neoplasms Antibodies  >55 publications with IGF1 and Prostatic Neoplasms
 Necrosis Antibodies  >48 publications with IGF1 and Necrosis
 Pituitary Neoplasms Antibodies  >47 publications with IGF1 and Pituitary Neoplasms
 Hypertension Antibodies  >41 publications with IGF1 and Hypertension
 Kidney Diseases Antibodies  >36 publications with IGF1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >299 publications with IGF1 and Muscle
 Liver Antibodies  >269 publications with IGF1 and Liver
 Bone Antibodies  >265 publications with IGF1 and Bone
 Brain Antibodies  >219 publications with IGF1 and Brain
 Vascular Antibodies  >121 publications with IGF1 and Vascular
 Ovary Antibodies  >111 publications with IGF1 and Ovary
 Heart Antibodies  >109 publications with IGF1 and Heart
 Connective Tissue Antibodies  >104 publications with IGF1 and Connective Tissue
 Lung Antibodies  >88 publications with IGF1 and Lung
 Prostate Antibodies  >81 publications with IGF1 and Prostate
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