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Il1b recombinant protein :: IL-1 BETA Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS232385 Il1b recombinant protein
Unit / Price
0.01 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-1 BETA (Il1b), Recombinant Protein

 Also Known As   

RECOMBINANT RAT INTERLEUKIN-1 BETA

 Product Gene Name   

Il1b recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q63264
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 Purity/Purification    >98% by SDS PAGE and HPLC analysis
 Form/Format    Purified recombinant protein - lyophilised.
 Concentration    Total protein concentration 0.1 mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.1 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Buffer Solution    10mM Sodium Acetate pH6.5
 Activity    This item has a specific activity of > 1 x 107 units/mg as determined by dose-dependent stimulation of proliferation of murine D10S cells.
 Target Species    Rat
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of Il1b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Il1b recombinant protein

   MBS232385 is an E Coli-derived recombinant protein corresponding to full-length mature rat interleukin 1 beta (IL-1b), an immunomodulary cytokine that mediates a wide range of immune responses.
 Applications Tested/Suitable for Il1b recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for Il1b recombinant protein    ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well;
Functional Assays: Minimum Dilution: 0.1; Maximum Dilution: 10ng/ml;
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane
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NCBI/Uniprot data below describe general gene information for Il1b. It may not necessarily be applicable to this product.
 NCBI GI #    2497335
 NCBI GeneID    24494
 NCBI Accession #    Q63264.1 [Other Products]
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 UniProt Primary Accession #    Q63264 [Other Products]
 UniProt Related Accession #    Q63264 [Other Products]
 Molecular Weight    Protein Molecular Weight: 17.3kD (153 Amino acid sequence) [Similar Products]
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 NCBI Official Full Name    Interleukin-1 beta
 NCBI Official Synonym Full Names    interleukin 1 beta
 NCBI Official Symbol    Il1b [Similar Products]
 NCBI Protein Information    interleukin-1 beta; IL-1 beta
 UniProt Protein Name    Interleukin-1 beta
 Protein Family    Interleukin
 UniProt Gene Name    Il1b [Similar Products]
 UniProt Synonym Gene Names    IL-1 beta [Similar Products]
 UniProt Entry Name    IL1B_RAT
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 NCBI Summary for Il1b    an inflammatory cytokine [RGD, Feb 2006]
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 UniProt Comments for Il1b    IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family.

Protein type: Cytokine

Cellular Component: extracellular space; extracellular region; vesicle; secretory granule

Molecular Function: protein domain specific binding; interleukin-1 receptor binding; cytokine activity

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of MAP kinase activity; positive regulation of JNK activity; positive regulation of nitric oxide biosynthetic process; negative regulation of glutamate secretion; glycoprotein metabolic process; activation of MAPK activity; positive regulation of apoptosis; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; response to glucocorticoid stimulus; germ cell programmed cell death; negative regulation of insulin receptor signaling pathway; positive regulation of glial cell differentiation; positive regulation of NF-kappaB import into nucleus; response to lipopolysaccharide; positive regulation of lipid catabolic process; fever; response to organic cyclic substance; positive regulation of membrane protein ectodomain proteolysis; response to carbohydrate stimulus; activation of NF-kappaB transcription factor; elevation of cytosolic calcium ion concentration; response to vitamin D; pentacyclic triterpenoid metabolic process; positive regulation of phagocytosis; positive regulation of T cell proliferation; positive regulation of astrocyte differentiation; response to drug; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of mitosis; positive regulation of interleukin-6 production; interleukin-1 beta production; social behavior; response to organic nitrogen; purine base metabolic process; positive regulation of angiogenesis; negative regulation of neuron differentiation; response to ethanol; response to heat; positive regulation of cell division; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of lipid metabolic process; leukocyte migration; response to peptide hormone stimulus; estrogen metabolic process; sequestering of triacylglycerol; wound healing; positive regulation of interleukin-6 biosynthetic process; response to morphine; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; response to L-ascorbic acid; chronic inflammatory response to antigenic stimulus; response to estradiol stimulus; positive regulation of stress-activated MAPK cascade; negative regulation of neurogenesis; positive regulation of interleukin-8 production; negative regulation of cell proliferation; learning and/or memory; negative regulation of lipid catabolic process; hyaluronan biosynthetic process; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; response to gamma radiation; regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; response to nutrient; aging; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; positive regulation of immature T cell proliferation in the thymus; memory; response to ATP; ovulation; polyketide metabolic process; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; response to ozone; positive regulation of prostaglandin secretion; response to hypoxia; positive regulation of fever; immune response; positive regulation of protein amino acid phosphorylation; regulation of insulin secretion
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 Research Articles on Il1b    1. acting as a physiological analog of rapamycin, IL-1beta impaired BDNF signaling by way of inhibiting mTOR activation as follows: the cytokine induced caspase-independent neuronal death
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Il1b recombinant proteinOrgans/Tissues associated with Il1b recombinant protein
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >80 publications with Il1b and Lung
 Liver Antibodies  >47 publications with Il1b and Liver
 Kidney Antibodies  >25 publications with Il1b and Kidney
 Eye Antibodies  >19 publications with Il1b and Eye
 Connective Tissue Antibodies  >18 publications with Il1b and Connective Tissue
 Ovary Antibodies  >16 publications with Il1b and Ovary
 Spleen Antibodies  >13 publications with Il1b and Spleen
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