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IL1R2 recombinant protein :: IL-1 receptor type II (CD121b) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553264 IL1R2 recombinant protein
Unit / Price
0.05 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $655 +1 FREE 8GB USB
1 mg  /  $2,525 +3 FREE 8GB USB
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 Product Name   

IL-1 receptor type II (CD121b) (IL1R2), Recombinant Protein

★Popular Item★
 Also Known As   

Mouse IL-1 receptor type II Recombinant (CD121b)

 Product Synonym Names    Mouse IL-1 receptor type II Recombinant; CD121B; D2S1473; IL-1R1; IL1R2; IL1RB; P80; IL1R2
 Product Gene Name   

IL1R2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    IL-1R2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P27931
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 Purity/Purification    >97%, as determined by SDS-PAGE and HPLC
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 Source    Optimized DNA sequence encoding Mouse extracellular domain of mouse IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells
 Biological Activity    Measured in an ELISA assay . The ability of mouse IL1R2 (10ug/ml) to bind biotinylated human IL1B was determined to be 0.5 ug/ml
 Molecular weight    Recombinant mouse IL-1 receptor type II (CD121b) is a protein consisting of 350 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
 Presentation    Recombinant Mouse IL-1 receptor II (CD121b) is lyophilized from 0.2 um filtered PBS solution, pH7.2 , 5% Trehalose,0.01% tween80
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 Preparation and Storage    Recombinant Mouse IL1R2 can be stored in working aliquots at 2C- 8C for one month, or at -20C to -70C for twelve months.
Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of IL1R2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL1R2 recombinant protein

   Two distinct IL-lRs have been identified, termed type I and type II. The type I IL-lR is an 80-kDa glycoprotein found predominantly on T cells and fibroblasts, whereas the type II IL-lR is a 60- to 65-kDa molecule that is expressed on activated T cells, B cells, monocytes, and neutrophils. Evidence suggests that the type II IL-lR is not signal- transducing, and its function on the cell surface is unknown. The action of IL-1 is modulated not only by IL-lra but also by the release of a type II soluble IL-iR (sIL-lR). This 47-kDa soluble receptor is present in normal human plasma, serum, and synovial inflammatory exudate and in culture supernatants of activated peripheral blood mononuclear cells and neutrophils. sIL-lR is also released from the human B-cell Burkitt lymphoma cell line Raji, which expresses only type II IL-1R.
 Product Categories/Family for IL1R2 recombinant protein    Receptors CD
NCBI/Uniprot data below describe general gene information for IL1R2. It may not necessarily be applicable to this product.
 NCBI GI #    6754330
 NCBI GeneID    16178
 NCBI Accession #    NP_034685.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010555.4 [Other Products]
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 UniProt Primary Accession #    P27931 [Other Products]
 Molecular Weight    Recombinant mouse IL-1 receptor type II (CD121b) is a protein consisting of 350 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.
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 NCBI Official Full Name    interleukin-1 receptor type 2
 UniProt Protein Name    Interleukin-1 receptor type 2
 UniProt Synonym Protein Names   
CD121 antigen-like family member B; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II
 Protein Family    Interleukin-1 receptor
 UniProt Gene Name    Il1r2 [Similar Products]
 UniProt Synonym Gene Names    Il-1r2; Il1rb; IL-1R-2; IL-1RT-2; IL-1RT2; IL-1R-beta; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII [Similar Products]
 UniProt Entry Name    IL1R2_MOUSE
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 UniProt Comments for IL1R2    IL-1RB: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; plasma membrane; integral to membrane; extracellular region

Molecular Function: interleukin-1, Type II, blocking receptor activity; interleukin-1 receptor activity
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Product References and Citations for IL1R2 recombinant protein

   pellino 2 is critical for toll-like receptor/interleukin-1 receptor (tlr/IL-1R) -mediated post-transcriptional control .J. Biol. Chem., Jul 2012; 287: 25686 - 25695.
role of toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/toll-like receptor signaling, in resistance to acute pseudomonas aeruginosa lung infection .Infect. Immun., Jan 2012; 80: 100 - 109.
IL-1R–associated kinase-1 mediates protein kinase c-induced il-1β production in monocytes .J. Immunol., Sep 2011; 187: 2632 - 2645.
effect of mitomycin c on IL-1R expression, il-1–related hepatocyte growth factor secretion and corneal epithelial cell migration .Invest. Ophthalmol. Vis. Sci., Mar 2010; 51: 1389 - 1396.
mycobacterium bovis bacillus calmette-guérin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo t cell priming via IL-1R–dependent nitric oxide production .J. Immunol., Feb 2010; 184: 2038 - 2047.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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