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IL11RA recombinant protein :: IL-11 receptor alpha Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553276 IL11RA recombinant protein
Unit / Price
0.1 mg  /  $220 +1 FREE 8GB USB
0.5 mg  /  $745 +1 FREE 8GB USB
1 mg  /  $1,155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-11 receptor alpha (IL11RA), Recombinant Protein

 Also Known As   

Mouse IL-11 receptor alpha Recombinant

 Product Synonym Names    IL-11RA; IL11ra
 Product Gene Name   

IL11RA recombinant protein

[Similar Products]
 Product Synonym Gene Name    IL-11 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSSSCSGLTR VLVAVATALV SSSSPCPQAW GPPGVQYGQP GRPVMLCCPG VSAGTPVSWF RDGDSRLLQG PDSGLGHRLV LAQVDSPDEG TYVCQTLDGV SGGMVTLKLG FPPARPEVSC QAVDYENFSC TWSPGQVSGL PTRYLTSYRK KTLPGAESQR ESPSTGPWPC PQDPLEASRC VVHGAEFWSE YRINVTEVNP LGASTCLLDV RLQSILRPDP PQGLRVESVP GYPRRLHASW TYPASWRRQP HFLLKFRLQY RPAQHPAWST VEPIGLEEVI TDAVAGLPHA VRVSARDFLD AGTWSAWSPE AWGTPSTGPL QDEIPDWSQG HGQQLEAVVA QEDSPAPARP SLQPDPRPLD HRDPLEQVAV LASLGIFSCL GLAVGALALG LWLRLRRSGK DGPQKPGLLA PMIPVEKLPG IPNLQRTPEN FS
 3D Structure    ModBase 3D Structure for Q64385
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 Purity/Purification    >85%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant mouse Interleukin-11receptor alpha was lyophilized from a 0.2 um filtered PBS solution pH 7.4.
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 Source    HEK Cells
 Domain    Extracellular
 Source Note    DNA sequence encoding extracellular domain of Mouse IL-11RA fused to a C-terminal polyHis tag was expressed in HEK cells.
 Biological Activity    The activity was determined by its ability to bind mouse IL-6ST in functional ELISA.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
 Molecular Weight Note    Recombinant Mouse Interleukin-11RA is a monomer consisting of 355 amino acid residue subunits, and migrates as an approximately 46 kDa protein under reducing conditions in SDS-PAGE.
 Presentation    Recombinant mouse Interleukin-11 alpha was lyophilized from a 0.2um filtered PBS solution pH 7.4.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of IL11RA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IL11RA recombinant protein

   Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.
 Product Categories/Family for IL11RA recombinant protein    Receptors CD
NCBI/Uniprot data below describe general gene information for IL11RA. It may not necessarily be applicable to this product.
 NCBI GI #    254281269
 NCBI GeneID    16157
 NCBI Accession #    NP_001156873.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001163401.1 [Other Products]
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 UniProt Primary Accession #    Q64385 [Other Products]
 UniProt Secondary Accession #    Q6NSQ0; A2AMS4 [Other Products]
 Molecular Weight    46,655 Da
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 NCBI Official Full Name    interleukin-11 receptor subunit alpha-1
 UniProt Protein Name    Interleukin-11 receptor subunit alpha-1
 UniProt Synonym Protein Names   
Enhancer trap locus homolog 2; Etl-2; Novel cytokine receptor 1
 Protein Family    Interleukin-11 receptor
 UniProt Gene Name    Il11ra1 [Similar Products]
 UniProt Synonym Gene Names    Etl2; Il11ra; IL-11 receptor subunit alpha-1; IL-11R subunit alpha-1; IL-11R-alpha-1; IL-11RA1; Etl-2; NR-1; NR1 [Similar Products]
 UniProt Entry Name    I11RA_MOUSE
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 UniProt Comments for IL11RA    IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: interleukin-11 binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-11 receptor activity

Biological Process: maternal process involved in pregnancy; natural killer cell differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; decidualization; placenta development
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Product References and Citations for IL11RA recombinant protein

   il-11 receptor in the pathogenesis of il-13-induced inflammation and remodeling .J. Immunol., Feb 2005; 174: 2305 - 2313.
recombinant soluble interleukin-11 (il-11) receptor -chain can act as an il-11 antagonist .Blood, Dec 1997; 90: 4403 - 4412.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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