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IL12 recombinant protein :: IL-12p40 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS845331 IL12 recombinant protein
Unit / Price
0.01 mg  /  $230 +1 FREE 8GB USB
0.05 mg  /  $600 +1 FREE 8GB USB
1 mg  /  $4,090 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-12p40 (IL12), Recombinant Protein

★Popular Item★
 Also Known As   

IL-12p40, human recombinant

 Product Synonym Names    Cytotoxic lymphocyte maturation factor 40 kDa subunitShort name=CLMF p40IL-12 subunit p40NK cell stimulatory factor chain 2
 Product Gene Name   

IL12 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    161561
 3D Structure    ModBase 3D Structure for P29460
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 Host    E Coli
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 Purity/Purification    >98% by SDS-PAGE and HPLC analysis
 Form/Format    Sterile filtered and lyophilized powder
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 Endotoxin Level    <0.1 ng per ug of IL-12p40
 Reconstitution    Reconstitute in 1X PBS, pH 7.2 to a concentration of 0.1-1 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4C for 1 week or -20C for future use.
 Handling    Centrifuge the vial prior to opening.
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 Preparation and Storage    The lyophilized powder is best stored desiccated below 0C. Reconstituted protein should be stored at working aliquots at -20C.
 Other Notes    Small volumes of IL12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IL12 recombinant protein

   Background: Interleukin-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Recombinant Human IL-12 p40 produced in E.Coli is a single, non-glycosylated Polypeptide chain containing 306 amino acids fragment (23-328).
 Applications Tested/Suitable for IL12 recombinant protein   

SDS-PAGE; HPLC

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NCBI/Uniprot data below describe general gene information for IL12. It may not necessarily be applicable to this product.
 NCBI GI #    24497438
 NCBI GeneID    3593
 NCBI Accession #    NP_002178.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002187.2 [Other Products]
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 UniProt Primary Accession #    P29460 [Other Products]
 UniProt Related Accession #    P29460 [Other Products]
 Molecular Weight    40.0 kDa
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 NCBI Official Full Name    interleukin-12 subunit beta
 NCBI Official Synonym Full Names    interleukin 12B
 NCBI Official Symbol    IL12B [Similar Products]
 NCBI Official Synonym Symbols   
CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B
[Similar Products]
 NCBI Protein Information    interleukin-12 subunit beta
 UniProt Protein Name    Interleukin-12 subunit beta
 UniProt Synonym Protein Names   
Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2
 UniProt Gene Name    IL12B [Similar Products]
 UniProt Synonym Gene Names    NKSF2; IL-12B; CLMF p40; NKSF2 [Similar Products]
 UniProt Entry Name    IL12B_HUMAN
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 NCBI Summary for IL12    This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL12    IL12B: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Genetic variations in IL12B are a cause of susceptibility to psoriasis type 11 (PSORS11). Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q31.1-q33.1

Cellular Component: extracellular space; membrane; interleukin-12 complex; cytoplasm

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; protein binding; interleukin-12 alpha subunit binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; interleukin-23 receptor binding; cytokine activity; interleukin-12 receptor binding

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of cell adhesion; positive regulation of T-helper 1 type immune response; negative regulation of interleukin-10 production; negative regulation of smooth muscle cell proliferation; positive regulation of interleukin-12 production; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of tyrosine phosphorylation of Stat4 protein; positive regulation of NF-kappaB import into nucleus; defense response to Gram-negative bacterium; positive regulation of activated T cell proliferation; sensory perception of pain; positive regulation of interleukin-10 production; positive regulation of natural killer cell activation; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of lymphocyte proliferation; natural killer cell activation during immune response; positive regulation of T cell proliferation; negative regulation of inflammatory response to antigenic stimulus; cell cycle arrest; defense response to virus; regulation of cytokine biosynthetic process; positive regulation of memory T cell differentiation; positive regulation of interleukin-17 production; T-helper 1 type immune response; positive regulation of NK T cell activation; positive regulation of natural killer cell proliferation; cell migration; T-helper cell differentiation; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; cytokine and chemokine mediated signaling pathway; positive regulation of tumor necrosis factor production; defense response to protozoan; regulation of tyrosine phosphorylation of Stat1 protein; response to UV-B; positive regulation of interferon-gamma production; positive regulation of tissue remodeling; negative regulation of interleukin-17 production; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of mononuclear cell proliferation; sexual reproduction; interferon-gamma biosynthetic process; positive regulation of defense response to virus by host; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process

Disease: Immunodeficiency 29
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 Research Articles on IL12    1. IL12B gene SNPs were found to not be associated with multiple sclerosis susceptibility in a Chinese southern population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL12 recombinant proteinDiseases associated with IL12 recombinant protein
 Reference Product  PubMed Publications
 IL12A recombinant protein  >59 publications with IL12 and IL12A
 IL4 recombinant protein  >46 publications with IL12 and IL4
 IL6 recombinant protein  >46 publications with IL12 and IL6
 IL12RB1 recombinant protein  >41 publications with IL12 and IL12RB1
 JUN recombinant protein  >40 publications with IL12 and JUN
 IL23A recombinant protein  >34 publications with IL12 and IL23A
 IL1B recombinant protein  >31 publications with IL12 and IL1B
 IL12RB2 recombinant protein  >14 publications with IL12 and IL12RB2
 NOS2 recombinant protein  >9 publications with IL12 and NOS2
 FOS recombinant protein  >1 publications with IL12 and FOS
 Disease Name  Pubmed Publications
 Psoriasis Antibodies  >77 publications with IL12 and Psoriasis
 Inflammation Antibodies  >68 publications with IL12 and Inflammation
 Necrosis Antibodies  >48 publications with IL12 and Necrosis
 Crohn Disease Antibodies  >32 publications with IL12 and Crohn Disease
 Lung Diseases Antibodies  >32 publications with IL12 and Lung Diseases
 Arthritis, Psoriatic Antibodies  >25 publications with IL12 and Arthritis, Psoriatic
 Liver Diseases Antibodies  >21 publications with IL12 and Liver Diseases
 Colitis, Ulcerative Antibodies  >19 publications with IL12 and Colitis, Ulcerative
 Disease Models, Animal Antibodies  >16 publications with IL12 and Disease Models, Animal
 Asthma Antibodies  >16 publications with IL12 and Asthma
Organs/Tissues associated with IL12 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >2 publications with IL12 and Mixed
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