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IL-1beta recombinant protein

Scan QR to view Datasheet Catalog #    MBS695909 IL-1beta recombinant protein
Unit / Price
0.002 mg  /  $125 +1 FREE 8GB USB
0.01 mg  /  $195 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-1beta, Recombinant Protein

★Popular Item★
 Also Known As   

Murine IL-1beta

 Product Synonym Names    Recombinant Murine IL-1beta
 Product Gene Name   

IL-1beta recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MVPIRQLHY RLRDEQQKS LVLSDPYEL KALHLNGQN INQQVIFSM SFVQGEPSN DKIPVALGL KGKNLYLSC VMKDGTPTL QLESVDPKQ YPKKKMEKR FVFNKIEVK SKVEFESAE FPNWYISTS QAEHKPVFL GNNSGQDII DFTMESVSS
 3D Structure    ModBase 3D Structure for P10749
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 Host    E Coli
 Species Reactivity    Species Reactivity: Mouse
Cross Reactivity: Human, Monkey, Pig, Rat, Mouse, Chicken
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 Purity/Purification    Above 98% as determined by SDS-PAGE Analysis.
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 Biological Activity    The ED50 as determined by the dose-dependent stimulation of murine D10S cells is <= 0.002 ng/ml, corresponding to a specific activity of >= 5 x 108 units/mg.
 Cell Type    B Cells, Monocytes and Macrophages
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of IL-1beta recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL-1beta recombinant protein

   IL-1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. Recombinant murine IL-1beta is a 17.5 kDa protein containing 153 amino acid residues.
 Product Categories/Family for IL-1beta recombinant protein    Innate Immunity; Stem Cell Research; Immunology; Cancer; Angiogenesis; Neurosciences; Inflammation; Proliferation and Cell Cycle; Metabolic Regulation and Diabetes
NCBI/Uniprot data below describe general gene information for IL-1beta. It may not necessarily be applicable to this product.
 NCBI GI #    124304
 NCBI GeneID    16176
 NCBI Accession #    P10749.1 [Other Products]
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 UniProt Primary Accession #    P10749 [Other Products]
 UniProt Secondary Accession #    Q2M4J6 [Other Products]
 UniProt Related Accession #    P10749 [Other Products]
 Molecular Weight    30,931 Da
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 NCBI Official Full Name    Interleukin-1 beta
 NCBI Official Synonym Full Names    interleukin 1 beta
 NCBI Official Symbol    Il1b [Similar Products]
 NCBI Official Synonym Symbols   
Il-1b; IL-1beta
[Similar Products]
 NCBI Protein Information    interleukin-1 beta; IL-1 beta
 UniProt Protein Name    Interleukin-1 beta
 UniProt Gene Name    Il1b [Similar Products]
 UniProt Synonym Gene Names    IL-1 beta [Similar Products]
 UniProt Entry Name    IL1B_MOUSE
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 NCBI Summary for IL-1beta    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]
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 UniProt Comments for IL-1beta    IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family.

Protein type: Cytokine

Cellular Component: extracellular space; cell; extracellular region; intracellular; cytosol; vesicle; secretory granule

Molecular Function: protein domain specific binding; interleukin-1 receptor binding; cytokine activity; receptor binding

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of JNK activity; negative regulation of MAP kinase activity; positive regulation of nitric oxide biosynthetic process; negative regulation of glutamate secretion; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; germ cell programmed cell death; negative regulation of insulin receptor signaling pathway; positive regulation of lipid catabolic process; response to lipopolysaccharide; positive regulation of NF-kappaB import into nucleus; positive regulation of glial cell differentiation; fever; positive regulation of membrane protein ectodomain proteolysis; response to carbohydrate stimulus; activation of NF-kappaB transcription factor; elevation of cytosolic calcium ion concentration; positive regulation of phagocytosis; positive regulation of T cell proliferation; positive regulation of astrocyte differentiation; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of mitosis; positive regulation of interleukin-6 production; interleukin-1 beta production; social behavior; positive regulation of angiogenesis; negative regulation of neuron differentiation; positive regulation of cell division; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of lipid metabolic process; leukocyte migration; sequestering of triacylglycerol; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of stress-activated MAPK cascade; negative regulation of neurogenesis; positive regulation of interleukin-8 production; negative regulation of cell proliferation; negative regulation of lipid catabolic process; hyaluronan biosynthetic process; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; inflammatory response; regulation of I-kappaB kinase/NF-kappaB cascade; aging; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; positive regulation of immature T cell proliferation in the thymus; response to ATP; memory; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of fever; immune response; positive regulation of protein amino acid phosphorylation; regulation of insulin secretion
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 Research Articles on IL-1beta    1. NLRP3 inflammasome activation and IL-1beta release play a crucial role in the pathogenesis of experimental allergic asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL-1beta recombinant proteinPathways associated with IL-1beta recombinant protein
 Reference Product  PubMed Publications
 Il6 recombinant protein  >268 publications with IL-1beta and Il6
 Tnf recombinant protein  >263 publications with IL-1beta and Tnf
 Il1a recombinant protein  >190 publications with IL-1beta and Il1a
 Casp1 recombinant protein  >60 publications with IL-1beta and Casp1
 Il1r1 recombinant protein  >36 publications with IL-1beta and Il1r1
 Il18 recombinant protein  >30 publications with IL-1beta and Il18
 Nfkb1 recombinant protein  >23 publications with IL-1beta and Nfkb1
 Myd88 recombinant protein  >20 publications with IL-1beta and Myd88
 Rela recombinant protein  >18 publications with IL-1beta and Rela
 Il1r2 recombinant protein  >12 publications with IL-1beta and Il1r2
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Diseases associated with IL-1beta recombinant proteinOrgans/Tissues associated with IL-1beta recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >379 publications with IL-1beta and Inflammation
 Necrosis Antibodies  >237 publications with IL-1beta and Necrosis
 Skin Diseases Antibodies  >52 publications with IL-1beta and Skin Diseases
 Stomach Neoplasms Antibodies  >41 publications with IL-1beta and Stomach Neoplasms
 Arthritis, Rheumatoid Antibodies  >26 publications with IL-1beta and Arthritis, Rheumatoid
 Hypersensitivity Antibodies  >23 publications with IL-1beta and Hypersensitivity
 Adenocarcinoma Antibodies  >23 publications with IL-1beta and Adenocarcinoma
 Asthma Antibodies  >21 publications with IL-1beta and Asthma
 Myocardial Ischemia Antibodies  >19 publications with IL-1beta and Myocardial Ischemia
 Colitis Antibodies  >17 publications with IL-1beta and Colitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >314 publications with IL-1beta and Blood
 Lung Antibodies  >74 publications with IL-1beta and Lung
 Brain Antibodies  >46 publications with IL-1beta and Brain
 Bone Marrow Antibodies  >30 publications with IL-1beta and Bone Marrow
 Muscle Antibodies  >26 publications with IL-1beta and Muscle
 Spleen Antibodies  >10 publications with IL-1beta and Spleen
 Lymph Node Antibodies  >9 publications with IL-1beta and Lymph Node
 Vagina Antibodies  >5 publications with IL-1beta and Vagina
 Mammary Gland Antibodies  >5 publications with IL-1beta and Mammary Gland
 Thymus Antibodies  >3 publications with IL-1beta and Thymus
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