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CD126 recombinant protein :: IL-6 Receptor (IL-6R) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553305 CD126 recombinant protein
Unit / Price
0.01 mg  /  $220 +1 FREE 8GB USB
0.05 mg  /  $540 +1 FREE 8GB USB
0.5 mg  /  $2,835 +3 FREE 8GB USB
 
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 Product Name   

IL-6 Receptor (IL-6R) (CD126), Recombinant Protein

★Popular Item★
 Also Known As   

Mouse IL-6 Receptor Recombinant (IL-6R)

 Product Synonym Names    Mouse CD126 Recombinant (IL6 Receptor) ; cd-126 IL6R; CD126; IL-6R-1; IL-6R-alpha; IL6RA; MGC104991; IL6 Receptor
 Product Gene Name   

CD126 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P22272
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 Purity/Purification    >97%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant Mouse Interleukin-6 receptor (CD126) is supplied as a 0.2 um filtered PBS solution, pH7.2.
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 Source Note    Optimized DNA sequence encoding extracellular domain of mouse IL-6 receptor (CD126) including a C-terminal 6His tag was expressed in HEK293 cells.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Molecular Weight Note    Recombinant mouse IL-6 receptor (CD126) is a monomer protein consisting of 357 amino acid residue subunits, due to glycosylation migrates as an approximately 60-65 kDa protein on SDS-PAGE.
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 Preparation and Storage    Recombinant Mouse IL-6R, as supplied, can be stored in working aliquots at 2 - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CD126 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD126 recombinant protein

   The effects of IL-6 are mediated by a functional IL- 6 receptor (IL-6R), which consists in a heterodimer formed by an IL-6-binding α chain (IL-6Rα) and a signal- transducing subunit, gp130 or IL-6Rβ. Binding of IL-6 to the IL-6Rα induces homodimerization of two gp130 molecules, leading to intracellular signals.
 Product Categories/Family for CD126 recombinant protein    Receptors CD
NCBI/Uniprot data below describe general gene information for CD126. It may not necessarily be applicable to this product.
 NCBI GI #    110431356
 NCBI GeneID    16194
 NCBI Accession #    NP_034689.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_010559.2 [Other Products]
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 UniProt Primary Accession #    P22272 [Other Products]
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 NCBI Official Full Name    interleukin-6 receptor subunit alpha
 UniProt Protein Name    Interleukin-6 receptor subunit alpha
 UniProt Synonym Protein Names   
IL-6R 1
 UniProt Gene Name    Il6ra [Similar Products]
 UniProt Synonym Gene Names    Il6r; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA [Similar Products]
 UniProt Entry Name    IL6RA_MOUSE
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 UniProt Comments for CD126    IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: extracellular space; cell surface; membrane; apical plasma membrane; integral to membrane; extracellular region; interleukin-6 receptor complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein homodimerization activity; interleukin-6 receptor binding; enzyme binding; interleukin-6 binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity

Biological Process: negative regulation of collagen biosynthetic process; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; endocrine pancreas development; positive regulation of chemokine production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; cell growth
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Product References and Citations for CD126 recombinant protein

   anti-inflammatory effect of IL-6 receptor blockade on experimental corneal alkali burn .Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 4206.
exposure-response relationship of tocilizumab, an anti–IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis .J. Clin. Pharmacol., Feb 2012; 10.1177/0091270012437585.
impact of IL-6 receptor inhibition on human memory b cells in vivo: impaired somatic hypermutation in preswitch memory b cells and modulation of mutational targeting in memory b cells .Ann Rheum Dis, Aug 2011; 70: 1507 - 1510.
species specificity of adam10 and adam17 proteins in interleukin-6 (il-6) trans-signaling and novel role of adam10 in inducible IL-6 receptor shedding .J. Biol. Chem., Apr 2011; 286: 14804 - 14811.
anti-IL-6 receptor antibody (tocilizumab) : a b cell targeting therapy .Ann Rheum Dis, Mar 2011; 70: A57 - A58.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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