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IL7 recombinant protein :: IL-7 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS232250 IL7 recombinant protein
Unit / Price
0.01 mg  /  $450 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-7 (IL7), Recombinant Protein

 Also Known As   

RECOMBINANT HUMAN INTERLEUKIN-7

 Product Gene Name   

IL7 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146660
 3D Structure    ModBase 3D Structure for P13232
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 Purity/Purification    >98 % by SDS PAGE and HPLC
 Form/Format    Purified recombinant protein expressed in E Coli - lyophilised
 Concentration    Total protein concentration 0.1 mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.1 ml distilled water. For extended storage the addition of 0.1% BSA is recommended.Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
 Buffer Solution    10mM Acetic Acid
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of IL7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL7 recombinant protein

   Recombinant human IL-7 is 17.4 kDa protein comprised of 153 amino acids corresponing to the ful-length mature sequence. IL-7 is a potent lymphoid cell growth factor acting on Pre-B, Pro-B and early T cells. In a dose dependent cell proliferation assay using 2E8 cells this product shows a specific activity of > 2 x 106 units/mg. Recombinant human IL-7 is recognized by Rat anti Human IL-7 antibody clones BVD10-40F6 and BVD10-11C10 in ELISA.
 Applications Tested/Suitable for IL7 recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for IL7 recombinant protein    ELISA: Recombinant human IL-7 may be used as a standard for ELISA applications with either anti-Human IL-7 (purified) or anti-Human IL-7 (biotin conjugate).
Western Blot: Recombinant human IL-7 may be used as the positive control for western blotting applications with either anti-Human IL-7 (purified) or anti-Human IL-7 (biotin conjugate).
ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4 ng/well
Functional Assays: Minimum Dilution: 0.1ng/ml; Maximum Dilution: 10ng/ml
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0 ng/lane
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NCBI/Uniprot data below describe general gene information for IL7. It may not necessarily be applicable to this product.
 NCBI GI #    4504677
 NCBI GeneID    3574
 NCBI Accession #    NP_000871.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000880.3 [Other Products]
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 UniProt Primary Accession #    P13232 [Other Products]
 UniProt Secondary Accession #    Q5FBY5; Q5FBY9; A0N0L3 [Other Products]
 UniProt Related Accession #    P13232 [Other Products]
 Molecular Weight    Protein Molecular Weight: 17.4KD (153 amino acids) [Similar Products]
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 NCBI Official Full Name    interleukin-7 isoform 1
 NCBI Official Synonym Full Names    interleukin 7
 NCBI Official Symbol    IL7 [Similar Products]
 NCBI Official Synonym Symbols   
IL-7
[Similar Products]
 NCBI Protein Information    interleukin-7
 UniProt Protein Name    Interleukin-7
 Protein Family    Interleukin
 UniProt Gene Name    IL7 [Similar Products]
 UniProt Synonym Gene Names    IL-7 [Similar Products]
 UniProt Entry Name    IL7_HUMAN
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 NCBI Summary for IL7    The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
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 UniProt Comments for IL7    IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cytokine; Apoptosis; Cell development/differentiation; Cell cycle regulation

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-7 receptor binding; protein binding; growth factor activity; cytokine activity

Biological Process: positive regulation of organ growth; humoral immune response; organ morphogenesis; T cell lineage commitment; cell-cell signaling; positive regulation of T cell differentiation; regulation of gene expression; homeostasis of number of cells within a tissue; positive regulation of cell proliferation; negative regulation of catalytic activity; positive regulation of B cell proliferation; negative regulation of apoptosis; bone resorption
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 Research Articles on IL7    1. These results strongly suggest that IL-7/IL-7R prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL7 recombinant proteinPathways associated with IL7 recombinant protein
 Reference Product  PubMed Publications
 IL7R recombinant protein  >13 publications with IL7 and IL7R
 IL3 recombinant protein  >10 publications with IL7 and IL3
 IL2RG recombinant protein  >10 publications with IL7 and IL2RG
 IL2RA recombinant protein  >9 publications with IL7 and IL2RA
 JAK3 recombinant protein  >9 publications with IL7 and JAK3
 FOXP3 recombinant protein  >7 publications with IL7 and FOXP3
 IL9 recombinant protein  >7 publications with IL7 and IL9
 CSF2 recombinant protein  >4 publications with IL7 and CSF2
 JAK1 recombinant protein  >4 publications with IL7 and JAK1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-7 Signaling Pathway antibodies  Interleukin-7 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with IL7 recombinant proteinOrgans/Tissues associated with IL7 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with IL7 and Inflammation
 Necrosis Antibodies  >21 publications with IL7 and Necrosis
 Multiple Sclerosis Antibodies  >19 publications with IL7 and Multiple Sclerosis
 Lymphopenia Antibodies  >17 publications with IL7 and Lymphopenia
 Neoplasms, Experimental Antibodies  >15 publications with IL7 and Neoplasms, Experimental
 Death Antibodies  >14 publications with IL7 and Death
 Carcinoma Antibodies  >11 publications with IL7 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >7 publications with IL7 and Cell Transformation, Neoplastic
 Sepsis Antibodies  >6 publications with IL7 and Sepsis
 Hypersensitivity Antibodies  >6 publications with IL7 and Hypersensitivity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >212 publications with IL7 and Blood
 Bone Antibodies  >50 publications with IL7 and Bone
 Thymus Antibodies  >40 publications with IL7 and Thymus
 Lymph Node Antibodies  >20 publications with IL7 and Lymph Node
 Skin Antibodies  >14 publications with IL7 and Skin
 Spleen Antibodies  >12 publications with IL7 and Spleen
 Liver Antibodies  >10 publications with IL7 and Liver
 Brain Antibodies  >9 publications with IL7 and Brain
 Intestine Antibodies  >8 publications with IL7 and Intestine
 Kidney Antibodies  >5 publications with IL7 and Kidney
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