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IL1B recombinant protein

Scan QR to view Datasheet Catalog #    MBS8249256 IL1B recombinant protein
Unit / Price
0.01 mg  /  $255 +1 FREE 8GB USB
0.05 mg  /  $635 +1 FREE 8GB USB
0.5 mg  /  $2,370 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL1B, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse IL1B Protein

 Product Synonym Names    IL1F2; Interleukin-1 beta; IL-1 beta; Catabolin
 Product Gene Name   

IL1B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    VPIRQLHYRL RDEQQKSLVL SDPYELKALH LNGQNINQQV IFSMSFVQGE PSNDKIPVAL GLKGKNLYLS CVMKDGTPTL QLESVDPKQY PKKKMEKRFV FNKIEVKSKV EFESAEFPNW YISTSQAEHK PVFLGNNSGQ DIIDFTMESV SS
 3D Structure    ModBase 3D Structure for P10749
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 Species Reactivity    Mouse
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 Purity/Purification    Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
 Form/Format    Lyophilized from a 0.2 uM filtered solution of 50mM Tris-HCl, 50mM NaCl, pH 8.0.
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 Source    E.Coli
 Quality Control    Endotoxin: Less than 0.1 ng/ ug (1 IEU/ug) as determined by LAL test.
 Directions for Use    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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 Preparation and Storage    Lyophilized protein should be stored at -20C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8C for 2-7 days. Aliquots of reconstituted samples are stable at -20C for 3 months.
 Other Notes    Small volumes of IL1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL1B recombinant protein

   Recombinant Mouse IL1B Protein is produced by E. coli. It is a single non-glycosylated polypeptide chain containing 152 amino acids with a molecular mass of 17400 Daltons.
 Applications Tested/Suitable for IL1B recombinant protein   

E, WB, SDS-PAGE ,MS

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NCBI/Uniprot data below describe general gene information for IL1B. It may not necessarily be applicable to this product.
 NCBI GI #    6680415
 NCBI GeneID    16176
 NCBI Accession #    NP_032387.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008361.4 [Other Products]
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 UniProt Primary Accession #    P10749 [Other Products]
 UniProt Secondary Accession #    Q2M4J6 [Other Products]
 UniProt Related Accession #    P10749 [Other Products]
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 NCBI Official Full Name    interleukin-1 beta
 NCBI Official Synonym Full Names    interleukin 1 beta
 NCBI Official Symbol    Il1b [Similar Products]
 NCBI Official Synonym Symbols   
Il-1b; IL-1beta
[Similar Products]
 NCBI Protein Information    interleukin-1 beta
 UniProt Protein Name    Interleukin-1 beta
 Protein Family    Interleukin
 UniProt Gene Name    Il1b [Similar Products]
 UniProt Synonym Gene Names    IL-1 beta [Similar Products]
 UniProt Entry Name    IL1B_MOUSE
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 NCBI Summary for IL1B    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]
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 UniProt Comments for IL1B    IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family.

Protein type: Cytokine

Cellular Component: extracellular region; extracellular space; secretory granule; vesicle

Molecular Function: cytokine activity; interleukin-1 receptor binding; protein domain specific binding

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; cytokine and chemokine mediated signaling pathway; elevation of cytosolic calcium ion concentration; germ cell programmed cell death; hyaluronan biosynthetic process; inflammatory response; interleukin-1 beta production; leukocyte migration; lipopolysaccharide-mediated signaling pathway; MAPKKK cascade; memory; negative regulation of cell proliferation; negative regulation of glutamate secretion; negative regulation of insulin receptor signaling pathway; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of astrocyte differentiation; positive regulation of chemokine biosynthetic process; positive regulation of fever; positive regulation of glial cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of heterotypic cell-cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of immature T cell proliferation in the thymus; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of lipid catabolic process; positive regulation of membrane protein ectodomain proteolysis; positive regulation of mitosis; positive regulation of neuron apoptosis; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of phagocytosis; positive regulation of prostaglandin secretion; positive regulation of protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein kinase B signaling cascade; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of insulin secretion; regulation of nitric-oxide synthase activity; response to ATP; response to carbohydrate stimulus; response to lipopolysaccharide; sequestering of triacylglycerol; social behavior
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 Research Articles on IL1B    1. ARTD1 controls osteoclast development and bone remodelling via its enzymatic activity by modulating the epigenetic marks surrounding the IL-1beta promoter and expression of IL-1beta and subsequently also Nfatc1/A.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL1B recombinant proteinPathways associated with IL1B recombinant protein
 Reference Product  PubMed Publications
 Il6 recombinant protein  >486 publications with IL1B and Il6
 Il1a recombinant protein  >248 publications with IL1B and Il1a
 Casp1 recombinant protein  >185 publications with IL1B and Casp1
 Il18 recombinant protein  >89 publications with IL1B and Il18
 Il1r1 recombinant protein  >52 publications with IL1B and Il1r1
 Myd88 recombinant protein  >45 publications with IL1B and Myd88
 Nfkb1 recombinant protein  >37 publications with IL1B and Nfkb1
 Il1r2 recombinant protein  >17 publications with IL1B and Il1r2
 Nfkb2 recombinant protein  >9 publications with IL1B and Nfkb2
 Il1rap recombinant protein  >5 publications with IL1B and Il1rap
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Diseases associated with IL1B recombinant proteinOrgans/Tissues associated with IL1B recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >975 publications with IL1B and Inflammation
 Necrosis Antibodies  >644 publications with IL1B and Necrosis
 Disease Models, Animal Antibodies  >275 publications with IL1B and Disease Models, Animal
 Skin Diseases Antibodies  >109 publications with IL1B and Skin Diseases
 Arthritis, Rheumatoid Antibodies  >60 publications with IL1B and Arthritis, Rheumatoid
 Hypersensitivity Antibodies  >51 publications with IL1B and Hypersensitivity
 Stomach Neoplasms Antibodies  >50 publications with IL1B and Stomach Neoplasms
 Colitis Antibodies  >45 publications with IL1B and Colitis
 Myocardial Ischemia Antibodies  >38 publications with IL1B and Myocardial Ischemia
 Asthma Antibodies  >38 publications with IL1B and Asthma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >745 publications with IL1B and Blood
 Brain Antibodies  >204 publications with IL1B and Brain
 Lung Antibodies  >169 publications with IL1B and Lung
 Bone Marrow Antibodies  >86 publications with IL1B and Bone Marrow
 Muscle Antibodies  >77 publications with IL1B and Muscle
 Spleen Antibodies  >36 publications with IL1B and Spleen
 Lymph Node Antibodies  >17 publications with IL1B and Lymph Node
 Mammary Gland Antibodies  >12 publications with IL1B and Mammary Gland
 Vagina Antibodies  >9 publications with IL1B and Vagina
 Thymus Antibodies  >8 publications with IL1B and Thymus
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