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IL1RN recombinant protein

Scan QR to view Datasheet Catalog #    MBS204721
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL1RN, Recombinant Protein

 Also Known As   

IL1RN, 27-178aa, Mouse, His tag, E Coli

 Product Synonym Names    Interleukin 1 receptor antagonist; F630041P17Rik; IL-1ra
 Product Gene Name   

IL1RN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMRPSGK RPCKMQAFRI WDTNQKTFYL RNNQLIAGYL QGPNIKLEEK IDMVPIDLHS VFLGIHGGKL CLSCAKSGDD IKLQLEEVNI TDLSKNKEED KRFTFIRSEK GPTTSFESAA CPGWFLCTTL EADRPVSLTN TPEEPLIVTK FYFQEDQ
 3D Structure    ModBase 3D Structure for P25085
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Mouse
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of IL1RN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL1RN recombinant protein

   Interleukin 1 receptor antagonist (IL1RN), also known as IL1-RA, is a member of the interleukin 1 cytokine family. IL1RN may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is no limit the pro-inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes. IL1RN is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Recombinant mouse IL1RN protein, fused to His-tag at N-terminus was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for IL1RN recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for IL1RN recombinant protein   

SDS-PAGE

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 SDS-Page of IL1RN recombinant protein    IL1RN recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for IL1RN. It may not necessarily be applicable to this product.
 NCBI GI #    89257344
 NCBI GeneID    16181
 NCBI Accession #    NP_001034790 [Other Products]
 NCBI GenBank Nucleotide #    NM_001039701.3 [Other Products]
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 UniProt Primary Accession #    P25085 [Other Products]
 UniProt Secondary Accession #    O70207 [Other Products]
 UniProt Related Accession #    P25085 [Other Products]
 Molecular Weight    20.0 kDa (177aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    interleukin-1 receptor antagonist protein isoform 2
 NCBI Official Synonym Full Names    interleukin 1 receptor antagonist
 NCBI Official Symbol    Il1rn [Similar Products]
 NCBI Official Synonym Symbols   
IL-1ra; F630041P17Rik
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor antagonist protein
 UniProt Protein Name    Interleukin-1 receptor antagonist protein
 UniProt Synonym Protein Names   
IL1 inhibitor
 Protein Family    Interleukin-1 receptor antagonist protein
 UniProt Gene Name    Il1rn [Similar Products]
 UniProt Synonym Gene Names    Il-1ra; IL-1RN; IL-1ra; IRAP [Similar Products]
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 UniProt Comments for IL1RN    Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
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Product References and Citations for IL1RN recombinant protein

   Steinkasserer A., et al. (1992) Genomics. 13 (3):654-7.; Langdahl BL., et al. (2000) J Bone Miner Res. 15 (3): 403-14.
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 Research Articles on IL1RN    1. Findings identify a critical role for IL1Ra in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 in mucosal Th17 cell induction associated with the development of autoimmune disease in mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL1RN recombinant proteinPathways associated with IL1RN recombinant protein
 Reference Product  PubMed Publications
 Il1b recombinant protein  >262 publications with IL1RN and Il1b
 Il1a recombinant protein  >125 publications with IL1RN and Il1a
 Il6 recombinant protein  >122 publications with IL1RN and Il6
 Il1r1 recombinant protein  >28 publications with IL1RN and Il1r1
 Il1r2 recombinant protein  >10 publications with IL1RN and Il1r2
 Irak2 recombinant protein  >9 publications with IL1RN and Irak2
 Myd88 recombinant protein  >8 publications with IL1RN and Myd88
 Il1rap recombinant protein  >5 publications with IL1RN and Il1rap
 Irak3 recombinant protein  >2 publications with IL1RN and Irak3
 Il1rl2 recombinant protein  >2 publications with IL1RN and Il1rl2
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
Diseases associated with IL1RN recombinant proteinOrgans/Tissues associated with IL1RN recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >809 publications with IL1RN and Necrosis
 Inflammation Antibodies  >787 publications with IL1RN and Inflammation
 Arthritis, Rheumatoid Antibodies  >314 publications with IL1RN and Arthritis, Rheumatoid
 Skin Diseases Antibodies  >142 publications with IL1RN and Skin Diseases
 Pain Antibodies  >91 publications with IL1RN and Pain
 Kidney Diseases Antibodies  >84 publications with IL1RN and Kidney Diseases
 Liver Diseases Antibodies  >68 publications with IL1RN and Liver Diseases
 Fibrosis Antibodies  >60 publications with IL1RN and Fibrosis
 Stroke Antibodies  >45 publications with IL1RN and Stroke
 Stomach Neoplasms Antibodies  >41 publications with IL1RN and Stomach Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1152 publications with IL1RN and Blood
 Skin Antibodies  >136 publications with IL1RN and Skin
 Bone Marrow Antibodies  >72 publications with IL1RN and Bone Marrow
 Connective Tissue Antibodies  >63 publications with IL1RN and Connective Tissue
 Stomach Antibodies  >58 publications with IL1RN and Stomach
 Spleen Antibodies  >47 publications with IL1RN and Spleen
 Intestine Antibodies  >46 publications with IL1RN and Intestine
 Eye Antibodies  >41 publications with IL1RN and Eye
 Vagina Antibodies  >12 publications with IL1RN and Vagina
 Thymus Antibodies  >7 publications with IL1RN and Thymus
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