NP_001034790.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,996 Da
NCBI Official Full Name
interleukin-1 receptor antagonist protein isoform 2
NCBI Official Synonym Full Names
interleukin 1 receptor antagonist
NCBI Protein Information
interleukin-1 receptor antagonist protein
UniProt Protein Name
Interleukin-1 receptor antagonist protein
UniProt Synonym Protein Names
IL1 inhibitor
UniProt Synonym Gene Names
UniProt Entry Name
IL1RA_MOUSE
UniProt Comments for IL1RN
IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; Secreted; Secreted, signal peptide; Vesicle
Cellular Component: extracellular region; extracellular space; vesicle
Molecular Function: cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type I receptor binding; interleukin-1, Type II receptor binding
Biological Process: cytokine and chemokine mediated signaling pathway; fever; insulin secretion; lipid metabolic process; memory; negative regulation of apoptosis; negative regulation of cell migration; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; negative regulation of membrane potential; positive regulation of JNK activity; response to glucocorticoid stimulus; sensory perception of pain
Research Articles on IL1RN
Precautions
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Products associated with IL1RN recombinant protein
Pathways associated with IL1RN recombinant protein
Diseases associated with IL1RN recombinant protein
Organs/Tissues associated with IL1RN recombinant protein
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