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IL33 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539515 IL33 recombinant protein
Unit / Price
0.01 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL33, Recombinant Protein

 Also Known As   

IL33 protein (Mouse)

 Product Synonym Names    NF-HEV protein; IL-33 protein; IL 33 protein; IL-33; IL33; IL 33; Interleukin 33 protein
 Product Gene Name   

IL33 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of IL33 protein correspond ing to amino acids SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI.
 OMIM    608678
 3D Structure    ModBase 3D Structure for O95760
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 Host    Mouse
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    IL33 is a proinflammatory protein that shares structural and functional characteristics with the IL1 cytokine family. It binds and signals through the IL1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL33 induces production of TH2 cell related cytokines, including IL4, IL5 and IL13, and exerts multiple inflammation related bioactivities.
 Bioactivity    The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse D10S cells is approximately 0.5 ng/ml, corresponding to a specific activity of approximately 2 x 10^6units/mg.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of IL33 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL33 recombinant protein

   Purified recombinant Mouse IL33 protein
 Product Categories/Family for IL33 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for IL33 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for IL33. It may not necessarily be applicable to this product.
 NCBI GI #    15559209
 NCBI GeneID    90865
 NCBI Accession #    NP_254274.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_033439.3 [Other Products]
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 UniProt Primary Accession #    O95760 [Other Products]
 UniProt Secondary Accession #    Q2YEJ5; B2R8L1; B4DJ35; B4E1Q9; D3DRI5; E7EAX4 [Other Products]
 UniProt Related Accession #    O95760 [Other Products]
 Molecular Weight    17.5 kDa
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 NCBI Official Full Name    interleukin-33 isoform 1
 NCBI Official Synonym Full Names    interleukin 33
 NCBI Official Symbol    IL33 [Similar Products]
 NCBI Official Synonym Symbols   
DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
[Similar Products]
 NCBI Protein Information    interleukin-33
 UniProt Protein Name    Interleukin-33
 UniProt Synonym Protein Names   
Interleukin-1 family member 11; IL-1F11
 Protein Family    Interleukin
 UniProt Gene Name    IL33 [Similar Products]
 UniProt Synonym Gene Names    C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV [Similar Products]
 UniProt Entry Name    IL33_HUMAN
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 NCBI Summary for IL33    IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]
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 UniProt Comments for IL33    IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular space; transport vesicle; chromosome; nucleus

Molecular Function: protein binding; cytokine activity

Biological Process: positive regulation of interleukin-4 production; positive regulation of T-helper 2 type immune response; T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; transcription, DNA-dependent; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of immunoglobulin secretion; positive regulation of interleukin-13 production; negative regulation of leukocyte migration; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
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 Research Articles on IL33    1. It was concluded that, in the IL33/ST2 signal pathway, the A allele of rs4624606 polymorphism of IL-1RaP gene is a potential independent risk factor for MI, and the genotypes AA+AT and AT are associated with the incidence of MI
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL33 recombinant proteinPathways associated with IL33 recombinant protein
 Reference Product  PubMed Publications
 IL1RL1 recombinant protein  >175 publications with IL33 and IL1RL1
 CASP1 recombinant protein  >17 publications with IL33 and CASP1
 IL6 recombinant protein  >14 publications with IL33 and IL6
 KIT recombinant protein  >6 publications with IL33 and KIT
 TNFSF11 recombinant protein  >3 publications with IL33 and TNFSF11
 VEGFA recombinant protein  >3 publications with IL33 and VEGFA
 ITGAM recombinant protein  >2 publications with IL33 and ITGAM
 TFF2 recombinant protein  >1 publications with IL33 and TFF2
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with IL33 recombinant proteinOrgans/Tissues associated with IL33 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >205 publications with IL33 and Inflammation
 Asthma Antibodies  >104 publications with IL33 and Asthma
 Lung Diseases Antibodies  >97 publications with IL33 and Lung Diseases
 Hypersensitivity, Immediate Antibodies  >96 publications with IL33 and Hypersensitivity, Immediate
 Necrosis Antibodies  >60 publications with IL33 and Necrosis
 Cardiovascular Diseases Antibodies  >57 publications with IL33 and Cardiovascular Diseases
 Heart Diseases Antibodies  >35 publications with IL33 and Heart Diseases
 Fibrosis Antibodies  >24 publications with IL33 and Fibrosis
 Dermatitis, Atopic Antibodies  >22 publications with IL33 and Dermatitis, Atopic
 Disease Models, Animal Antibodies  >21 publications with IL33 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >63 publications with IL33 and Lung
 Heart Antibodies  >49 publications with IL33 and Heart
 Skin Antibodies  >47 publications with IL33 and Skin
 Vascular Antibodies  >36 publications with IL33 and Vascular
 Muscle Antibodies  >22 publications with IL33 and Muscle
 Intestine Antibodies  >21 publications with IL33 and Intestine
 Liver Antibodies  >17 publications with IL33 and Liver
 Brain Antibodies  >13 publications with IL33 and Brain
 Connective Tissue Antibodies  >11 publications with IL33 and Connective Tissue
 Eye Antibodies  >9 publications with IL33 and Eye
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